Intracellular Events and Cell Fate in Filovirus Infection (NIH Aug 2011)Filoviruses have a broad cell tropism in susceptible host species. Among the target cells supporting viral replication are monocytes, macrophages, dendritic cells (DCs), hepatocytes, adrenal cortical cells, fibroblasts and endothelial cells [43–57].
The earliest events during infection are likely to center around cells of the mononuclear phagocyte system, including monocytes, macrophages, and DCs. These cells not only orchestrate innate and adaptive immune responses [58,59], but also serve as early targets of viral infection [47–49,55,56, 60–66]. It is thought that the early infection of these cells is responsible for the rapid and widespread dissemination of the virus throughout an infected host [67].
More grateful thanks. You’ve given me enough to put me on another track.