A large population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease—aortic stenosis (AS). Aortic stenosis is a debilitating heart condition. It causes a narrowing of the aortic valve, restricting blood flow out of the heart. If not addressed, this can gradually cause damage that can lead to life-threatening complications, such as heart failure. People living with AS can take years to develop symptoms, which include chest pain, tiredness, shortness of breath and heart palpitations. Insulin resistance, which often develops years before the onset...