Chemotherapy is known for its painful side-effects. It also has limitations when the cancer has metastasized to the lymph nodes. The lymphatic drug delivery system (LDDS), where anticancer drugs are injected directly into the sentinel lymph nodes under ultrasound guidance, offers an alternative to conventional chemotherapy. Researchers found the optimal osmotic pressure and viscosity ranges, significantly improving the antitumor effect. Cancer often transfers from its primary lesion to other lesions—clinically referred to as metastasis. In early metastasis, cancer cells invade lymphatic vessels, reach lymph nodes, and proliferate. Conventional chemotherapy for metastatic lymph nodes has limitations because only part of anticancer...