Indianapolis, IN Indianapolis is the capital of the U.S. state of Indiana and the seat of Marion County. It is located in the East North Central region of the Midwest, near the confluence of the White River and Fall Creek. The city covers 372 square miles (963.5 km²) and had an estimated population of 848,788 in 2014, making it the largest city in Indiana, second largest in the Midwest, and 14th largest in the U.S.Approximately 1,971,274 people live in the Indianapolis metropolitan area (MSA), the 33rd most populous MSA in the U.S. Its combined statistical area (CSA) ranks 26th, with...