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New cancer-killing method found in stem cells, cells showing potential in cancer fight
msnbc ^ | 05.19.09

Posted on 05/19/2009 9:36:36 PM PDT by Coleus

Genetically engineered stem cells from bone marrow showed promise as a potential new way to deliver a cancer-killing protein to tumors, British researchers said on Tuesday. Experiments in cell cultures and in mice showed the adult stem cells — a type known as mesenchymal stem cells — could home in on cancer cells and deliver a lethal protein that attacked only the cancer while sparing normal healthy tissue.

“We’ve developed cells which specifically target cancer through the body and deliver an anti-cancer protein to where it is needed in a seek-and-destroy approach,” said Dr. Michael Loebinger of University College London, who presented his findings at the American Thoracic Society conference in San Diego. “Essentially, we’ve combined two pieces of research. The first is that mesenchymal stem cells have an innate ability to seek out tumors throughout the body,” Loebinger said in a telephone interview.

Loebinger, Dr. S. M. Janes and colleagues altered the cells to express or make the cancer-killing protein called TNF-related apoptosis-inducing ligand or TRAIL. “This protein has the ability to cause the death only of cancer cells. By combining these two approaches, we have a cell which has the ability to go around the body and find and destroy tumors,” Loebinger said.

Studies in cell cultures showed the cells were able to find and kill cells from lung, squamous, breast and cervical cancer. “Lots of cancer have sensitivity to this TRAIL protein,” Loebinger said. They also injected the cells into mice with breast tumors and showed they were able to safely kill the tumors but leave healthy tissue intact. “When we delivered this therapy, 38 percent of the tumors were completely eliminated.”

(Excerpt) Read more at msnbc.msn.com ...


TOPICS: Culture/Society; News/Current Events; Testing; United Kingdom
KEYWORDS: adultstemcells; bonemarrow; cancer; genetics; stemcells; trailprotein

1 posted on 05/19/2009 9:36:36 PM PDT by Coleus
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To: 2ndMostConservativeBrdMember; afraidfortherepublic; Alas; al_c; american colleen; annalex; ...
Please notify me via FReepmail if you would like to be added to or taken off  the Pro-Life/Stem Cells/Conservative Issues Ping List. Sign up and Try Conservapedia instead of WickipediaInstead of Google, try Pro-Life Internet or CATHOLIC GOOGLE. For a list of 300 Pro-life Websites, click on Coleus and go all the way to the bottom
2 posted on 05/19/2009 9:37:19 PM PDT by Coleus (Abortion, Euthanasia & FOCA - - don't Obama and the Democrats just kill ya!)
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Stem Cells May Offer New Way to Treat Blocked Arteries (Adult Stem Cells)

Adult Stem Cells from Fat Tissue Offer Hope for MS Treatment

First-Ever Procedure Uses Patient's Own Adult Stem Cells to Treat Stroke Effects

(Adult) Stem Cells Jumpstart Bone's Healing Process

No borders in this battle against cancer [Adult Stem Cells]

Single factor converts adult stem cells into embryonic-like stem cells

Adult Stem Cells Successfully Reset Immune System for Multiple Sclerosis Patients

Study: (ADULT) Stem Cells Reverse Paralysis in Rats

Adult Stem Cells Already Help Spinal Cord Patients, FDA Embryonic Trials Not Needed

Another medical breakthrough with adult stem cells

To Russia, with hope of a miracle cure (adult stem cells for spinal cord injuries)

3 posted on 05/19/2009 9:37:48 PM PDT by Coleus (Abortion, Euthanasia & FOCA - - don't Obama and the Democrats just kill ya!)
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To: Coleus
Genetically engineered stem cells from bone marrow showed promise as a potential new way to deliver a cancer-killing protein to tumors,

No...how dare they? Only the cells of sacrificed human embryos can provide the cures!

4 posted on 05/19/2009 9:40:28 PM PDT by tflabo (Truth or Tyranny)
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To: neverdem
Like, *PING*, dude.

Cheers!

5 posted on 05/19/2009 10:04:36 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: Coleus

They must be itching to put “embryonic” in one of these breakthrough headlines. But it’s conspicuous by its absence.


6 posted on 05/19/2009 10:04:44 PM PDT by NonValueAdded ("Tyranny is always whimsical." Mark Steyn 3/9/2009)
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To: NonValueAdded

Notre Dame will supply them for the libs and lots of dead babies too.


7 posted on 05/19/2009 10:15:08 PM PDT by Frantzie
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To: grey_whiskers; Coleus

thanks, bfl


8 posted on 05/19/2009 10:37:46 PM PDT by neverdem (Xin loi minh oi)
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To: Coleus

Wow and double wow!!!!


9 posted on 05/19/2009 11:53:02 PM PDT by rawhide
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To: neverdem
Mesenchymal stem cells.

Leaps and bounds ping
10 posted on 05/20/2009 12:01:40 AM PDT by BIGLOOK
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To: BIGLOOK

TRAIL protein looks like an eventual Nobel! Thanks for the ping.


11 posted on 05/20/2009 12:36:58 AM PDT by neverdem (Xin loi minh oi)
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To: Coleus

Bookmark


12 posted on 05/20/2009 6:13:10 AM PDT by 2nd amendment mama ( www.2asisters.org | Self defense is a basic human right!)
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To: Coleus

bump


13 posted on 05/20/2009 7:58:15 AM PDT by dcwusmc (We need to make government so small that it can be drowned in a bathtub.)
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To: Coleus
Experiments in cell cultures and in mice showed the adult stem cells — a type known as mesenchymal stem cells — could home in on cancer cells and deliver a lethal protein that attacked only the cancer while sparing normal healthy tissue.

Now THIS is stem cell research that is deserving of support!

14 posted on 05/20/2009 8:43:46 AM PDT by SuziQ
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To: Coleus

bfl


15 posted on 05/20/2009 8:45:52 AM PDT by Skooz (Gabba Gabba we accept you we accept you one of us Gabba Gabba we accept you we accept you one of us)
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To: Coleus; grey_whiskers; BIGLOOK; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; ...
I withdraw the prediction of a Nobel prize, although it's a very interesting piece of work. There's no mention of immunoprivileged status in the abstract.

Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer.

It's a lentivirus method of gene therapy. Sixty two percent of the mice had no response or worse, i.e. graft versus host disease or host versus graft disease. Cancer patients are already considered immunocompromised. Any requirement for immunosuppressant drugs would increase morbidity and mortality, IMHO.

16 posted on 05/20/2009 10:20:12 AM PDT by neverdem (Xin loi minh oi)
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To: Coleus

bump


17 posted on 05/21/2009 12:35:33 AM PDT by dcwusmc (We need to make government so small that it can be drowned in a bathtub.)
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To: neverdem
look at this: PVCT

Rose Bengal ......Target and destroy the deadliest cancers – melanoma, liver & breast – while eliminating side effects. Clinical trials for metastatic melanoma and recurrent breast carcinoma are currently underway.

Provectus has developed groundbreaking biotechnologies to augment vaccine production and detect viruses (including an innovative “virus hunter” method)

KNOXVILLE, Tenn.--(BUSINESS WIRE)--Provectus Pharmaceuticals, Inc. (OTCBB: PVCT, http://www.pvct.com), a development-stage oncology and dermatology biopharmaceutical company, announced today that a poster, Abstract #9060, entitled "Chemoablation of melanoma with intralesional rose bengal (PV-10)", will be presented on June 1, 2009 in the 8:00 a.m. - 12:00 p.m. General Poster Session (Group F, Brd. F15), at the 2009 American Society of Clinical Oncology (ASCO) Scientific Program at the Orange County Convention Center in Orlando, Florida.

Dr. Sanjiv S. Agarwala, Principal Investigator for Provectus' Phase 2 PV-10 trial site at St. Luke's Hospital & Health Network in Bethlehem, PA will present an update on the development efforts with PV-10 for metastatic melanoma, including interim Phase 2 safety and efficacy data on the first 40 subjects in the trial and interim bystander correlation data on response of untreated tumors in subjects whose treated tumors responded successfully. Additional Phase 1 survival data will also be presented.

.

18 posted on 05/21/2009 1:24:24 AM PDT by Elle Bee
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