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Buckyballs could disrupt functioning of DNA
New Scientist ^ | 12/09/2005 | Kurt Kleiner

Posted on 12/10/2005 11:50:27 AM PST by md2576

Computer simulations show that a common nanoparticle called a buckyball has the potential to damage DNA. The simulations suggest that buckyballs bind strongly to the DNA strands, distorting the molecules and interfering with functions like self-repair.

Researchers caution that the simulations do not prove that buckyballs actually do any damage in the real world. But the work does raise another concern about possible dangers of nanotechnology.

On Thursday, the US Environmental Protection Agency released a draft paper that called for more research into the safety of nanotechnology, saying that there are a number of unanswered questions about possible effects on health and the environment.

The worry is that even familiar materials, such as carbon, might have completely different health effects at the nanoscale. One recent study, for instance, found that buckyballs accumulate in the brains of largemouth bass and cause cell damage. Drug delivery

Buckyballs, or buckminsterfullerenes (C60), are hollow spheres made from 60 carbon atoms. Because of their unique physical properties they are being considered for many applications, from drug delivery to fuel cells.

Researchers at Oak Ridge National Laboratory in Tennessee, and Vanderbilt University in Nashville, both in the US, decided to investigate how buckyballs would react if they came into contact with DNA. They used standard biomolecular simulation software to model two strands of DNA, with 12 base pairs each, interacting with two buckyballs over about 20 nanoseconds.

They found that the buckyballs bind strongly to DNA, with about the same energy that drugs bind to receptors on the surface of cells. When the buckyballs bound, they distorted the strands of DNA. Peter Cummings, a Vanderbilt chemical engineer, says it seems likely the interaction would interfere with the DNA's function, disrupting replication and repair and increasing mutation rates.

(Excerpt) Read more at newscientist.com ...


TOPICS: Business/Economy; Culture/Society; Miscellaneous; News/Current Events
KEYWORDS: buckyballs; dna; epa; nanotech; science
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To: Paul_Denton

"In the computer game Deus Ex it could be used both ways. The Gray Death nano-virus (central to the game's plot) was actually the same nanites that gave the Dentons their enhanced abilities. The only difference betwen nano-virus and nano augmentation was the propgramming of the nanites themselves."

Pauldentoncheatsenabled


21 posted on 12/10/2005 12:33:03 PM PST by dljordan
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To: Cicero
There's already science fiction novels suggesting that nanotechnology...

'Prey' by Michael Crichton deals with this.

22 posted on 12/10/2005 12:35:22 PM PST by Vinnie
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To: md2576
Hey, this is Christmas.

The season of hope and good cheer and presents and goodwill towards men (except Muslims and DemocRats) and enough "Happy RamaHanuKwanzMas"'s for everyone!

23 posted on 12/10/2005 12:35:22 PM PST by manwiththehands (Happy RamaHanuKwanzMas!)
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To: md2576

Buckyball, what a scientific name! Makes you wonder doesn't it?


24 posted on 12/10/2005 12:36:30 PM PST by calex59 (Seeing the light shouldn't make you blind...)
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To: calex59

Be sure to keep your buckyballs away from your nanotube.


25 posted on 12/10/2005 12:40:04 PM PST by msf92497 (Was Republican...Now just a Conservative.)
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To: manwiththehands

Too True!
Merry Christmas!


26 posted on 12/10/2005 12:41:09 PM PST by md2576 (Merry RamaHanuKwanzMas! ..................Merry Christmas too.)
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To: calex59
That's the nickname. The scientific name is buckminsterfullerenes. According to Wickepedia, "The Fullerenes are a recently discovered allotrope of carbon (the best known being diamond and graphite). They are molecules composed entirely of carbon, taking the form of a hollow sphere, ellipsoid, or tube. Spherical fullerenes are sometimes called buckyballs, while cylindrical fullerenes are called buckytubes or nanotubes."

Actually, I think buckminsterfullerene is reserved for the smallest of these fullerenes, C60. The obvious reason is that they look very much like one of Bucky Fuller's domes.

Here's a picture of fullarene C540:


27 posted on 12/10/2005 12:47:06 PM PST by Cicero (Marcus Tullius)
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To: Cicero

Looks slippery!


28 posted on 12/10/2005 1:03:19 PM PST by Dr. Bogus Pachysandra ("Don't touch that thing")
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To: md2576
No wonder my buckyballs have been aching.
29 posted on 12/10/2005 1:34:19 PM PST by Barnacle (The Democrat Party consists of a gaggle of criminal defense attorneys, and their clients.)
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To: Cicero

The second time?


30 posted on 12/10/2005 2:28:07 PM PST by md2576 (Merry RamaHanuKwanzMas! ..................Merry Christmas too.)
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To: md2576

Suppose this is true, but cells cannot be penetrated, thus keeping DNA safe. Suppose then that one were to devise a way to weaken cell membranes of cells selectively, thus allowing one to target specific types of cells to be attacked by buckyballs. And suppose those were cancer cells. Hmmmm.


31 posted on 12/10/2005 2:36:34 PM PST by pepsi_junkie (Often wrong, but never in doubt!)
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To: md2576

Can modern day Ned Lude's and an army of tort lawyers be very far off in the nantechnology business?


32 posted on 12/10/2005 3:24:08 PM PST by The Great RJ ("Mir wölle bleiwen wat mir sin" or "We want to remain what we are." ..Luxembourg motto)
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To: AntiGuv
nano ping!
33 posted on 12/10/2005 8:25:49 PM PST by Wiz
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To: Cicero

Ah, a "mother-in-law & lobster boat" story. Did you "set'er agin"?


34 posted on 12/10/2005 8:48:40 PM PST by Calvin Locke
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To: md2576

Sounds like it has the potential to be weaponized - a "buckeybomb"!


35 posted on 12/10/2005 8:56:28 PM PST by Mannaggia l'America
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To: Calvin Locke

Let's not look too closely into the details.


36 posted on 12/10/2005 9:31:35 PM PST by Cicero (Marcus Tullius)
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To: gaijin
Of course, it was all BS, and it is a fact that about 80% of all US food is somehow genetically modified.

Can you be sure that the enormous increase in the rate of allergies, asthma, anaphylactic shock, etc., is not due to GM foods?

37 posted on 12/10/2005 10:40:46 PM PST by ImaGraftedBranch (God is my Fulcrum; prayer is my lever -- Saint Therese of Lisieux)
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To: PatrickHenry; b_sharp; neutrality; anguish; SeaLion; Fractal Trader; grjr21; bitt; KevinDavis; ...
FutureTechPing!
An emergent technologies list covering biomedical
research, fusion power, nanotech, AI robotics, and
other related fields. FReepmail to join or drop.

38 posted on 12/11/2005 2:24:54 PM PST by AntiGuv (™)
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To: Cicero
We went in to their dock to check our boat out because there was a smell of gasoline. When they pushed us off for the return journey, Bucky reached out and gave the boat a delicate little spin, so as it drifted out from the dock it turned around, and was headed toward the harbor entrance when I started the engine. He clearly had a good spatial sense.

Bucky's got balls.

39 posted on 12/12/2005 7:54:11 AM PST by Lazamataz (Liberals screwed again: HOLIDAY derives from the words Holy Day. NOW what will they do?)
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