Posted on 01/31/2005 1:30:06 PM PST by auggy
Researchers in Boston have pinpointed a primary trigger for the most common form of diabetes and have uncovered evidence that simple, inexpensive aspirin-like drugs could keep the disease that affects millions in check.
The researchers, from Joslin Diabetes Center in Boston, discovered a genetic ''master switch" in the liver that is turned on when people become obese. Obesity has long been linked to diabetes, but the reason, until now, has been unknown. Joslin researchers found that once on, this switch produces low-level inflammation, which disrupts the body's ability to process insulin, causing type 2 diabetes.
(Excerpt) Read more at boston.com ...
bttt
Shoelson is preparing an experiment to test if salicylates also can reduce CRP and thus heart disease risk.
I thought that the link between reducing risk for heart disease and aspirin was already established. At least that's why I thought my cardiologist put my on aspirin.... Seems like this guy is re-inventing the wheel just a bit.
His angle is a new one, CRP. The use of aspirin intially, and as you prescribed it) is because of its effects upon reducing prostaglandins, a substance which enhances clotting. Thus, there may be two effects of aspirin: reducing clotting by reducing prostoglandins and reducing CRP.
The government-agency/pharmaceutical complex is not interested in curing diseases. There is no long-term revenue stream generated by curing diseases.
The only kind of diabetes drug that will ever be devloped and approved is one that requires the patient to take it and pay for it every single day for the rest of their lives.
Okay, thanks for the explanation.
Many people are already taking one of the salicylates, sodium salicylate (aspirin), for its ability to reduce heart attacks.
See #7.
Your cardiologist put you on aspirin to prevent your platelets from sticking together and forming blood clots (which DOES reduce the risk of heart attack). Although it is widely established that aspirin also reduces inflammation, I don't think it is yet known whether aspirin affects the type of inflammation that the C-reactive protein is an indicator of.
Will this line of research lead to understanding why people who have diabetes are also at greater risk for heart disease? Diabestes, obesity, insulin resistance, heart disease - seems like there may be some underlying framework for all of these.
In a former life, I was actually a biology major. I've been away from it for too long now, though.
The FDA will not allow pharmaceutical companies to promote aspirin for this purpose, however, because the FDA requires millions of dollars in extortion money to approve a drug for a specific purpose.
Don't some people recommend that patients have their C-reactive protein levels checked as a means of assessing their risk?
Sheesh, I cannot keep up with everything!
The underlying framework is the consumption of sugar.
Sugar is the crack cocaine of foods.
It is highly addictive, and really bad for you.
Sugar is very good for you...in much smaller quantities than a typical American consumes. Same with Fat.
My research tends to indicate that sugar from corn syrup is significantly worse for you than "sugar." Unfortunately, most of the sugar we get is from corn syrup.
I think the medical folks feel that it is just a bit early in the research cycle for this to become a general recommendation for physicians. I asked my MD about it, and he said that since he already had me on statins for cholesterol, that there was no real need to make the measurement (evidently statins ALSO affect the C-reactive protein in a positive way).
Since my dad had a heart attack at about the age I am now, you can bet I follow this stuff.
BTTT
Of course, asprin takes out good prostoglandins too. That can have some bad effects. But probably worth it compared to diabeties. So probably better to control the weight and eating too much sugar and grains to begin with.
Since I already supplement CoQ10, I ought to be OK. I may need to up the dose of CoQ10 a bit.
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