Posted on 01/01/2026 4:12:42 PM PST by ConservativeMind
Scientists are working to understand how aging itself can be modified to prevent age-related diseases, including Alzheimer's disease.
A new study has discovered that calcium alpha-ketoglutarate (CaAKG), a safe, naturally occurring metabolite commonly studied for healthy aging, can restore key memory-related brain functions that have been disrupted in Alzheimer's disease.
The main aim of the study was to evaluate whether CaAKG could also enhance synaptic plasticity in the Alzheimer's brain, restore memory-related signaling, protect neurons from early degenerative changes, and contribute to healthier cognitive aging.
The study shows that CaAKG helps brain cells communicate better in Alzheimer's disease models. It not only repairs the weakened signals between neurons, but also restores associative memory, one of the early abilities lost in Alzheimer's. Because AKG levels naturally fall as we age, replenishing this molecule could be a promising way to support healthier brain aging and lower the risk of neurodegenerative diseases.
To understand how CaAKG helps the brain, the researchers measured long-term potentiation (LTP), which is the process that allows neurons to strengthen their connections. LTP is essential for learning and forming lasting memories, but in Alzheimer's disease it becomes severely impaired. The team found that CaAKG brought this signal-strengthening process back to normal. CaAKG also boosted autophagy, the brain's built-in "cleanup" system that removes damaged proteins and keeps neurons healthy.
The molecule worked through a newly identified pathway, helping neurons become more flexible by activating L-type calcium channels and calcium-permeable AMPA receptors, while avoiding NMDA receptors, which are often disrupted by amyloid buildup. Importantly, CaAKG restored synaptic tagging and capture, a key mechanism that allows the brain to link events and form associative memories. This suggests that CaAKG may support not just basic memory function, but also more complex learning abilities that decline early in Alzheimer's disease.
(Excerpt) Read more at medicalxpress.com ...
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“It not only repairs the weakened signals between neurons, but also restores associative memory, one of the early abilities lost in Alzheimer's.“
Calcium alpha-ketoglutarate (CaAKG) is readily available as a supplement. You want the calcium form of AKG.
We make less of this as we age.
From the paper:
“Ca-AKG, a calcium derivative of AKG, has emerged as a promising compound with potential benefits for aging and neurodegenerative diseases (Asadi Shahmirzadi et al. 2020; Zhang et al. 2023). Our previous work demonstrated that Ca-AKG supplementation extends lifespan and improves healthspan in mice (Asadi Shahmirzadi et al. 2020). Compared to free AKG, Ca-AKG offers several advantages, including greater chemical stability and improved bioavailability. Ca-AKG is acidic and absorbed more slowly in the gastrointestinal tract, resulting in a gradual and sustained release into the bloodstream. This prolonged absorption profile enables Ca-AKG to maintain its biological effects over an extended period, potentially enhancing its overall efficacy. Furthermore, AKG is a charged molecule with limited ability to cross cell membranes (Wu et al. 2016). “
There are multiple newer approaches to attack Alzheimer’s Disease and/or dementia, including a low carb diet or forms of fasting, the Mediterranean Diet, and supplements I’ve recently posted on, which include ultra-low-dose lithium orotate, EGCG (green tea) with Vitamin B3/nicotinamide.
Lithium loss ignites Alzheimer's, but lithium compound can reverse disease in mice (Lithium orotate)
https://freerepublic.com/focus/f-chat/4334274/posts
This Vitamin And Tea Combo May Quickly Rejuvenate Aging Brain Cells
thank
you !
i need to study up on all these things before Alzheimers strikes
cheer
Some say the medical cabal already has cures for Alzheimer’s, cancer and other chronic illnesses.
That they’re not telling us about.
That may be possible, but everyone insists on bad diets and not exercising, so who is really at fault for your own bad health?
We are.
Taking care of ourselves is the best way to prevent the problems you think the cures that are being held back, could cure.
Everyone dreams of an easy path and conspiracies that would let them not take responsibility for their own situation.
Maybe the power elites only want the best for us. Could be they just want the rest of the population to prosper and live long lives.
Why do you care what they want? Fight for what is right and stop letting conspiracies you can’t begin to prove, hold you back.
Bkmk
Notice that long, exotic-sounding metabolite contains the word “keto.”
Fighting for what’s right includes self defense. Only liberals don’t believe in self defense.
It’s a bit odd that you’re so fired up about protecting something you can’t prove.
The oil cartels took control of the medical establishment in 1905. Their game has been to make us sick so they can make untold billions treating us with their pharmaceuticals.
Placeholder post
It’s a bit odd that a Christian is bothered about conspiracies, when personal responsibility has always been expected.
Life isn’t fair, can’t be made fair, and was never meant to be fair.
You spend your angst on being mad at supposed oil cartels for our fallen world. I will continue knowing the world came that way and work with what I can and rely on God for the rest.
Bookmarked.
ping
Not exactly related to Alzheimer’s, but I once heard Dr. Amen say that the most beautiful brains he has seen imaging of are from people who take Gingko Biloba supplements.
Per AI overview:
“Dr. Daniel Amen, a prominent brain health expert, frequently recommends Ginkgo Biloba as a supplement to support brain function, particularly for improving blood flow, memory, focus, and mental clarity, often including it in his BrainMD supplements like Brain & Memory Power Max, due to its ability to enhance circulation and deliver oxygen and nutrients to the brain. He emphasizes that while exercise is crucial, Ginkgo, alongside other nutrients, helps combat age-related decline by improving vascular health and supporting cognitive processes.”
I always thought I could be an Alzheimer’s model, but my friends said I had lost my mind.
No, you don’t understand Christianity.
A real Christian is unafraid. The cabal has taught us to be afraid and not question the establishment. I say that’s nonsense.
It’s a sin to let evil doers go on with their evil. How many Scripture verses to you need from me on this? Our job is to find the perpetrators of evil and hold them accountable.
By the way, these people are Luciferians. They kill children in ritual sacrifice.
You better think hard about this.
All I see from you is that you think The Powers That Be are holding back cures for every health malady Mankind has.
I also see from you that you have zero proof, but you believe there is an important fight to be had with who and what must be making everyone eat bad and not exercise, and therefore dying earlier than they might have, if they could have eaten poorly, never exercised, and had these magic cures you seek for them.
I didn’t mean to upset you. I’m only giving my honest opinion.
And it should be noted that since the 2020 “pandemic,” the ground had shifted massively in my direction, not yours.
Furthermore, I warned everyone on this site and elsewhere that “covid” was not what the establishment was telling us it was, and that the “vaccine” wasn’t either. People died because they didn’t listen.
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