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Posted on 11/21/2025 9:03:19 PM PST by ConservativeMind
A study has explored whether adding branched-chain amino acids (BCAAs) to an exercise program could improve outcomes for older adults. In a small, randomized, double-blind, placebo-controlled trial, the team found that BCAA supplementation improved performance, reduced fatigue, and alleviated depression symptoms for many participants.
His research focuses on how inflammation impairs central nervous system function. BCAAs—leucine, isoleucine, and valine—are essential amino acids that not only serve as the building blocks of protein and muscle but also appear to play specific roles in inflammation and brain health.
"Through supplementation, we thought perhaps we could restore balance and reduce the burden of central fatigue, while also providing a boost to the physical benefits of exercise."
The pilot study enrolled 20 men and women with obesity and an average age of 70. Participants were randomized into two groups and asked to complete eight weeks of moderate aerobic exercise and strength training. One group received a placebo beverage, while the other consumed a BCAA beverage in a 2:1:1 ratio, emphasizing leucine.
"In our evidence and from literature, these amino acids do more than just serve as building blocks for protein. They have direct effects. Leucine has an effect on skeletal muscle and interplays with other amino acids transported into the brain that potentially have an effect on mental fatigue," O'Connor said.
After eight weeks, the exercise-only placebo group showed very modest or insignificant changes in strength and endurance, a 5% increase in fatigue, and scores on the depression scale increased. By contrast, the BCAA group showed a modest increase in strength and endurance, a 45% decrease in fatigue and a 29% reduction in depressive symptom scores.
In addition, his team is finishing work on a study testing the effects of supplemental leucine on physical and cognitive performance in aged mouse models.
(Excerpt) Read more at medicalxpress.com ...
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....” a small study”...
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