Posted on 11/11/2025 3:31:15 PM PST by ConservativeMind
An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.
Urolithin A is a metabolite produced naturally through microbial digestionin much smaller quantities than available as a supplement or used in the study.
Aging bodies face reduced production of mature T cells, shrinking naive T cell pools and chronic low-grade inflammation. Mitochondrial dysfunction and waning autophagy sit at the core of these shifts, with mitophagy failure linked to immune dysregulation and disease.
Preclinical evidence identified urolithin A as a potent inducer of mitophagy, clearing out damaged mitochondria, in rodents and humans.
Immunology studies have suggested a role in regulation of CD8+ T cell fate in mice, expanding T memory stem cells and naive-like T cells via mitophagy-elicited activation of the immune system. Exposure to urolithin A also conferred a favorable state on human CAR T cells ex vivo.
Improving mitochondrial quality control with a positive influence on immune function would represent a turning back of the aging biological clock, if it can have a meaningful and prolonged effect in humans.
Fifty healthy adults aged 45–70 years were randomized 1:1 to urolithin A or placebo for 28 days in a single-center, double-blind trial.
Urolithin A expanded CD8+ T cells with a more naive-like phenotype and lower expression of exhaustion markers, with a statistically significant treatment difference of 0.50 percentage points. Although numerically small, such changes can indicate meaningful remodeling of immune balance over a brief 28-day period.
Short-term urolithin A supplementation modulated human immune cell composition and metabolism and improved selected functional responses, supporting the body's potential to counteract age-related immune decline.
(Excerpt) Read more at medicalxpress.com ...
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Great, that’s the one I’ll check out.
You might want to try HCL; it solves the gluten/celiac issue. Most of us have very low acid (and don’t recognize it as it manifests as high acid, often). Try it and see if you feel better. You will also see nutrients become more effective bc the acid is doing it’s job
Because the doctors get kickbacks to promote bIG pHaRma poison instead. Were you asleep during the moderna/pfizer vs. Hydroxychloroquine/Ivermectin battle?
Are CTA and TDN safe? (going WAY back).
Vitamin D protects mitochondria against oxidative stress, while magnesium is often deficient but is essential to the repair and replacement of damaged mitochondria. Magnesium L-Threonate is an amino acid chelate that has superior absorption, including across the blood-brain barrier.
Collagen peptides are an absorbable form of collagen that helps to repair damaged blood vessels, skin, joints, and tendons. Collagen production in the body declines with age.
If this set of nutrients seems to cause pain or discomfort due to inflammation, reduce the dosages and add antioxidants like liposomal Vitamin C and tumeric. The inflammation is almost certainly due to the repair and replacement of damaged cells and will pass in time.
“Hard to tell if there are any benefits”
So very true for most supplements. I started NAC, Quercetin, Zinc, Vit C and Vit D during COVID. Had never taken any supplements before that. My doc recommended B12 (OTC) every third day and then added a Potassium supplement (not eating enough bananas).
Then I added Elderberry on my own.
Based on another ConservativeMind article a few days ago, I added a low daily dose of Mg.
So, does ANY of this do any good? I’m a healthy 74 year old male and still a lot of exhausting yard work. Today was Day 4 of fall yard cleanup. So far, I’ve collected, blown, raked, bagged, loaded into the car and emptied at the dump 1,200 pounds of yard waste.
Sounds like something well before my time:)
Because far too many drs are owned by big pharma and there’s not enough money in it.
Med Bookmark
Dr. Robert Malone was very positive on this. I searched through Amazon and found two months supply for ~$30.
The biggest pills, however! Have to make sure I take a big gulp of water while swallowing!
Bkmk look into this
Timeline
.
Maybe they have gotten ‘permission’ yet. (?)
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