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Posted on 11/11/2025 3:31:15 PM PST by ConservativeMind
An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.
Urolithin A is a metabolite produced naturally through microbial digestionin much smaller quantities than available as a supplement or used in the study.
Aging bodies face reduced production of mature T cells, shrinking naive T cell pools and chronic low-grade inflammation. Mitochondrial dysfunction and waning autophagy sit at the core of these shifts, with mitophagy failure linked to immune dysregulation and disease.
Preclinical evidence identified urolithin A as a potent inducer of mitophagy, clearing out damaged mitochondria, in rodents and humans.
Immunology studies have suggested a role in regulation of CD8+ T cell fate in mice, expanding T memory stem cells and naive-like T cells via mitophagy-elicited activation of the immune system. Exposure to urolithin A also conferred a favorable state on human CAR T cells ex vivo.
Improving mitochondrial quality control with a positive influence on immune function would represent a turning back of the aging biological clock, if it can have a meaningful and prolonged effect in humans.
Fifty healthy adults aged 45–70 years were randomized 1:1 to urolithin A or placebo for 28 days in a single-center, double-blind trial.
Urolithin A expanded CD8+ T cells with a more naive-like phenotype and lower expression of exhaustion markers, with a statistically significant treatment difference of 0.50 percentage points. Although numerically small, such changes can indicate meaningful remodeling of immune balance over a brief 28-day period.
Short-term urolithin A supplementation modulated human immune cell composition and metabolism and improved selected functional responses, supporting the body's potential to counteract age-related immune decline.
(Excerpt) Read more at medicalxpress.com ...
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It has other benefits, but it is basically all from helping the cells’ energy producer, mitochondria, work well, by getting rid of dysfunctional ones and allowing new ones to take their place.
Why would they prescribe something that is OTC?
OTC, ELP, or ELO, even JST, they still should, acronyms notwithstanding.
Don’t disagree with you, but that’s not how the vast majority of Dr’s function.
OTC, ELP, or ELO, even JST, they still should, acronyms notwithstanding.
What about XTC and REM?
I stand corrected. Thank you.
No kickbacks
And about 99% of doctors don’t understand or want to understand nutrition or exercise.
Just don’t take it INXS
This, in addition to all the payola incentivizing prescribers to stick with prescription drugs (and vaccines, since who needs a healthy immune system anyway? / sarc).
because doctors AREN’T efficacious
This is a new one for me. Will have to read some of the data on it.
There’s also Methylene Blue which is supposed to have benefits on mitochondria.
what brand on amzn?
“I could get Urolithin poisoning and die!”
The medical community dows not want you fixing yourself ! Theres no profit in that for them.
just take tylenol :)
My MD prescribes Vitamin C for me (along with 8 other supplements). Didn’t think I needed a covid shot. I’ve lived her 16 years and had one cold about 8 years ago.
Prevention is better than curing anything. Used to be a magazine called PREVENTION and I wrote articles for it.
And BTW, my MD went to med school in Nigeria where med schools are not given so much money by pharmaceutical companies.
Indeed! :)
I have been taking it for over a year.
Hard to tell if there are any benefits because I supplement a few other vitimins and minerals.
I have Celiac's syndrome so my body dosen't absorb all vitimins from food as well as it could so I rely on blood tests and supplements to make sure I am where I want to be.
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