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Posted on 11/11/2025 3:18:08 PM PST by ConservativeMind
Alzheimer's disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease.
In AD, a major contributor to neuronal dysfunction is the protein tau.
An international team of researchers has reported a new mechanism by which boosting the natural metabolite NAD⁺ can protect the brain from the degeneration associated with AD.
NAD⁺ (nicotinamide adenine dinucleotide, oxidized form) is a vital metabolite involved in energy metabolism and neuronal resilience in the body. It normally declines with age and especially in various neurodegenerative diseases.
"Preliminary studies have shown that supplementation with NAD⁺ precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), can offer therapeutic benefits in AD animal models and early clinical trials.
The new study reveals that NAD⁺ works through a previously unidentified RNA-splicing pathway. This pathway is regulated by a protein called EVA1C, which plays an essential role in the process of RNA splicing. Its dysregulation is one of the most recently acknowledged risk factors for AD.
The researchers discovered that when NAD⁺ levels are increased, EVA1C helps correct mistakes in RNA splicing. This restoration process improves the function of hundreds of genes, many crucial for brain health, which can help reverse the neurodegenerative damage caused by tau.
This analysis revealed that NAD⁺ promotes a specific form of EVA1C that efficiently binds to essential proteins, which are central to protein folding and clearance. This connection links metabolic homeostasis, RNA splicing processes and protein management, three processes that are critically impaired in AD.
"We propose that maintaining NAD⁺ levels could help preserve neuronal identity and delay cognitive decline, paving the way for combination treatments to enhance RNA splicing," Ai says.
(Excerpt) Read more at medicalxpress.com ...
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I mentioned in my original post I take NR.
It seems like nicotinamide riboside could be supplemented with a cigarette.
Yes...I posted that article here...also mentions coconut oil
https://freerepublic.com/focus/f-news/4351535/posts
You may find this interesting...esp coconut oil idea. You need fat with D3 supplementation.
https://freerepublic.com/focus/f-news/4351535/posts
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