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Posted on 10/12/2025 7:09:07 PM PDT by ConservativeMind
A supplement of ketones may be the magic bullet that allows patients using weight-loss drugs to avoid the potentially adverse side-effect of a shrinking heart and skeletal muscle, according to a study.
In their initial studies, Dyck's team confirmed the expected loss of skeletal muscle, which studies show can account for nearly 40% of the total weight loss.
To address the unknowns, the team looked at a natural energy source the body produces: ketones.
Ketones are produced by the liver when the body runs low on carbohydrates, typically during fasting or when following a low-carb, or ketogenic, diet. Recent work also showed that ketones are necessary to preserve skeletal muscle mass.
For the follow-up study, Dyck's team paired semaglutide with a ketone ester, a drinkable supplement that the body converts into ketones, mimicking the elevated levels of ketones in the blood.
The results in obese mice were dramatic.
"It turns out it does a fantastic job in protecting from muscle loss—skeletal muscle loss and loss of cardiac mass," says Dyck.
Mice that received the semaglutide and ketone ester combination did not lose as much total body weight as the group receiving semaglutide alone. However, further analysis showed that this lower total weight loss was actually a positive sign.
"When we looked deeper into where that weight loss came from, the same amount of fat was lost, but the ketones prevented muscle loss," Dyck says.
The mechanism behind this protective effect appears to be centered on the body's energy factories: mitochondria.
He explains that semaglutide appears to impair the mitochondria, which generate energy for the muscles. Without this energy, muscle can waste away. This process happens when the body begins to break down muscle for fuel.
"When you give animal models ketones, it protects the mitochondria from being impaired," Dyck says.
(Excerpt) Read more at medicalxpress.com ...
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These are available online and at health food stores.
So...Take another drug to counteract the drug you shouldn’t have been taking in the first place???
The medical stocks in my portfolio thank you for your support!
Once again... I think the mice are the winners in this study... And especially the obese mice.
What ever happened to just eating less
Doctors and patients believe semaglutide is a wonder drug, and it is for weight loss and lowering sugar levels, etc.
I knew they could cause muscle loss, and this confirms they can cause heart muscle loss. That doesn’t sound like a good thing.
Maybe ketones can help, but that’s not widely available.
And the semaglutide works on the brain, gut, digestion, and has hormone and protein effects, and suppresses certain cell receptors.
Plus a slight risk of thyroid cancer.
And whenever I look up could it cause all kinds of things, including oral outbreaks and skin sensitivity, there are statements that it could be the cause because it suppresses this that or the other thing.
A LOT of people are on them. I wonder how she they are.
Then again I met someone who lost a ton of weight with it, and was able to ditch 7 other drugs for diabetes and high blood pressure. His bad blood levels are now all within normal range.
You want us to believe someone who’s a Dyck?
Not into taking weight loss drugs, but losing weight almost always leads to a loss of strength if you lift weights.
Body builders do not care, appearance is everything.
Power lifters OTOH.
“What ever happened to just eating less...”
When the body is functioning normally, “eat less” works well. It is how our bodies are SUPPOSED to operate. But as someone who did low-fat, yo-yo diets for 45 years - and had been very fat as a baby/child - when your body’s hormones get out of whack, simply cutting calories can cause much of the weight loss to come from muscle. Making you weak and sickly.
In my mid-20s, I dieted down below 120 pounds - as a 5’8” male - and still had a thick layer of fat on my belly.
Going Keto at 59 changed my life. I lost weight, but from FAT instead of muscle. Thus I could sustain the diet, which has now just been “how I eat” for 8 years. I don’t have “6-pack abs” still but now have a ‘1-pack” with maybe 1/2” of fat over my abs. I’m 150 pounds and am stronger than I was 8 years ago.
So for “normal people”, calories in/out works well. And with few enough calories you WILL lose weight - but you can (when your body isn’t responding correctly) find yourself weak as a kitten. You simply cannot sustain that.
My sister never had weight issues and has never needed keto. I had them and did need keto to break the cycle. But I did NOT need “weight loss drugs”. You can achieve weight loss without muscle loss, for free, by going keto/carnivore.
Dr. Jason Fung - ‘Therapeutic Fasting - Solving the Two-Compartment Problem’
https://www.youtube.com/watch?v=tIuj-oMN-Fk
Pleasure sensors in the brain whenever someone eats.
One of the big gets in fasting and keto is improved mitochondrial health and efficiency
I am really concerned about taking anything that messes with mitochondrial function as mitochondrial degradation and deregulation is a root cause of many negative health and aging problems
“So...Take another drug to counteract the drug you shouldn’t have been taking in the first place???”
————
Ketones are NOT a drug. They are what the body produces naturally from fat when the body runs out of glucose. Ketones can also be found - quite naturally - in MCT oil, which oftentimes is made from coconuts. Ketones are quite healthy, especially for the mitochondria (discussed in the article here) and for the brain. People benefit from it, even in the absence of semiglutides or any other drugs.
Imagine an old dirty tennis shoe that has been tracking through a tar and gravel road. Take the rubber of those shoes and grind into a slurry. Drink that.
That rubberized slurry tastes much better than those ketone esters.
Your point is obvious, but the answer is = pharmaceutical corporations work very hard to get permanent paying customers. Whatever these weight loss drugs screw up, they’re going to have another product down the line to fix too.
here’s a crazy idea... stop shoving food in your pie hole!
The same phenomenon occurs in any calorie deficit.
Tell me you didn’t read the article without saying it!
Any diet results in muscle loss.
Bodybuilders have been doing this for decades, btw. Taking aminos to minimize muscle loss when cutting. They just did a shotgun approach.
Now it appears they’ve narrowed down the protein bits to ketones.
Ketones are a completely different set of chemicals than amino acids.
“ Ketones are a completely different set of chemicals than amino acids”
No, not at all.
Ketones are a component of several aminos, notably leucine, lysine, and others like phenylalanine, tyrosine, tryptophan, and isoleucine, all of which are classified as ketogenic because their carbon skeletons can be converted into ketone bodies.
Sigh. Just because some amino acids have ketone groups doesn’t mean they should be conflated.
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