Posted on 10/05/2025 5:15:14 PM PDT by ConservativeMind
A study indicates that changes in the body that lead to type 2 diabetes occur long before current diagnostic thresholds for prediabetes are met.
The study challenges conventional thinking about the onset of type 2 diabetes, identifying a risk category before prediabetes, called "pre-prediabetes." At this stage, people with normal glucose tolerance already have severe insulin resistance, early beta cell dysfunction and measurable cardiovascular disease.
In this study, DeFronzo's team of scientists examined people with normal glucose tolerance, per ADA standards, and found that one measurement—one-hour glucose levels during an OGTT—is far better at predicting future disease. A value between 120 and 155 mg/dL identified individuals likely to develop prediabetes, and eventually type 2 diabetes, years before standard criteria would spot them.
"The one-hour glucose is far superior to the two-hour glucose test for predicting who will progress," DeFronzo said. "Using this measure, we can see insulin resistance and beta cell problems well before the current definitions kick in."
Despite the evidence, the ADA does not currently recommend routine treatment of prediabetes, and there are no drugs approved by the Food and Drug Administration for prediabetes treatment. In high-risk cases, the ADA advises considering metformin, a drug DeFronzo now says is becoming obsolete.
He said today there are more effective treatments for type 2 diabetes, prediabetes and potentially pre-prediabetes. One drug DeFronzo champions is the insulin sensitizer pioglitazone, which has proven to reduce the progression from prediabetes to diabetes by 75%—more than double metformin's effect. Additionally, newer GLP-1 receptor agonists and dual agonists like semaglutide and tirzepatide can cut type 2 diabetes progression rates by up to 85%.
DeFronzo believes high-risk patients, especially those with strong family histories of diabetes or early cardiovascular disease, should be screened early and offered treatment long before they develop type 2 diabetes.
(Excerpt) Read more at medicalxpress.com ...
this topic reminds me of the useless term in school ...
pre-calculus
pre-algebra
Double secret diabetes.
Send more money now, for RESEARCH!
Next week: studies show that 100% of divorced people were once married...
“...early warning stage before prediabetes...”
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Pre-Pre-Diabetes!
This article seemed to say that people with pre prediabetes already have cardiovascular damage? I’m thinking they meant a subgroup already has damage?
Mine is under control (A1C 6.3) but that can change. You don't get to dictate what your pancreas is going to do.
Yes, that is how I took it, too.
There are people who already have a blood pressure or cholesterol issue, for instance, yet, the rest looks good.
This is saying it doesn’t look that good, because you likely haven’t been checked for insulin resistance, for instance. This is not an expensive test to get, privately, even, if needed.
Where Wegovy we go all...............
I had an A1C in the 8’s. I went on insulin, cut out the carbs to a controlled level, and within 6 months I was under 5.7. I got off shots and the “Semiglutide” and now use no insulin for 4 years. I was in my mid sixties. You can do it too.
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