Posted on 09/13/2025 7:53:44 PM PDT by SeekAndFind
Researchers reported evidence that a bacterium commonly associated with chronic gum disease could play a direct role in the development of Alzheimer’s.
The study, published in Science Advances, details how Porphyromonas gingivalis, the pathogen behind periodontitis, was detected in the brains of Alzheimer’s patients.
The findings come from an international team of scientists that included Jan Potempa, a microbiologist at the University of Louisville.
Potempa said the research offers some of the strongest evidence yet linking gum infection to Alzheimer’s pathology, though he stressed more work is needed to prove causation.
In animal studies, the team found that oral infection with P. gingivalis led to brain colonization.
It also triggered production of amyloid beta, a sticky protein fragment that forms the plaques widely recognized as a hallmark of Alzheimer’s disease.
Researchers also identified toxic enzymes produced by the bacterium, called gingipains, in neurons of Alzheimer’s patients.
The higher the gingipain levels, the greater the buildup of proteins linked to brain cell damage.
The study also explored a potential treatment pathway. By using a small-molecule drug to block gingipains, researchers reported reduced bacterial load, less amyloid beta production, and protection of neurons in the hippocampus, the region of the brain critical for memory.
Potempa noted that while the work opens the door to new therapeutic strategies, it also reinforces a simpler message: oral health could be more closely tied to brain health than previously understood.
I read a recent article where a doctor recommended of using alcohol based mouthwash as its one of the reason for loss of bacteria in the gut.
I brush with electric toothbrush, use little GUM sticks and flossers between teeth and then use waterpik. Waterpik gets more stuff out. So yes, it’s worth it.
#16 I googled: Christina Applegate and who else has MS
There are many people in entertainment that have MS.
my mom died of complications from MS so I pick up information when I can
I would love to hear of a study MS vs ivermectin
Google: ivermectin potential treatment for multiple sclerosis (MS)
Does not look like ivermectin works for MS.
However hydroxychloroquine (HCQ) potential treatment for multiple sclerosis (MS)
Does have articles saying may help.
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