Posted on 08/07/2025 12:34:30 PM PDT by Red Badger
It looks likely we'll see oral GLP-1 drugs on the market by next year, with pharmaceutical company Eli Lilly reporting impressive results following a large, robust 72-week trial that saw obese participants lose an average of 27.3 lb, or 12.4% of their body weight with the once-daily pill.
This week the company announced positive results from its Phase 3 ATTAIN-1 trial of the GLP-1 receptor agonist known as orforglipron, given to 3,127 adults with obesity over 72 weeks. In the long study, all doses passed their efficacy and tolerability benchmarks compared to a placebo, with clinically significant results across the board.
Now, the US drug maker is set to apply for global approval of orforglipron by the end of 2025, meaning it's likely to be the first oral weight-loss drug in this class and likely to be on offer in the new year.
"Obesity is one of the most pressing global health challenges of our time, driving global chronic disease burden and impacting more than one billion people worldwide," said Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health. "With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments."
"With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need," he added.
Trial participants on the highest dose lost an average of 27.3 lb (12.4%) at 72 weeks, and 59.6% of participants on this dose lost at least 10% of their body weight. What's more, 39.6% lost at least 15% of their body weight. Orforglipron also significantly lowered cardiovascular disease risk, including non-HDL cholesterol, triglycerides...
(Excerpt) Read more at newatlas.com ...
Or alcohol.😏
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
A lot of info left out there...
Do you drink alcohol, soda, juices, or other sweet drinks?
Oh for Pete’s sake!...................
Interesting...
You can’t make an anagram using all of the letters.
Wonder if that’s deliberate.
Yes I do. I know sweets are the main culprit, as well as my crappy metabolism. However, I don’t eat fast food, junk food, chips, or sodas on a regular basis so it could be a lot worse. I’ve deprived myself of sweets and other fun foods for most of my adult life, and at almost 72, I’ve decided life’s too short for that. I’m not obese, just overweight and I can live with that fact, even though I hate what the extra weight has done to my body.
I’m sending you a dm. What I have to say is too long for the forum lol.
I was fed up and I remember what my husband's cousin said to me years before “Don't drink your calories “. So I decided to cut out from my diet liquid calories. I didn't change anything I ate. I just drank water, coffee and tea
(With a splash of no fat milk). By doing just this I lost 25 lbs in 6 months.
My next step was to pick one meal where I ate the same thing every day. I picked breakfast. I have a yogurt and coffee every day. It's a form of portion and weight control and getting my mind off food.
Fast forward over the years I've never gained weight I've lost more. At the age of 70 I weigh 117lb (and I'm down 2 inches) I actually can't eat a heavy meal any more. I never deny myself anything food wise but I can't eat large portions.
The last thing is don't eat a late dinner. You can still lose weight doing little tricks with your diet. If I did it anyone can because I'm not the most disciplined person in the world. Good luck!
My DM ended up on the board. Oh well anyone can read my weight journey if interested.
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