Posted on 07/27/2025 5:57:49 PM PDT by ransomnote
[H/T CheshireTheCat]
The 10 deadliest cancers share one thing: a common metabolic driver. Learn how repurposed drugs can help stop them, and download the free guide by Dr. Paul Marik and Dr. Justus R. Hope.
Each year, cancer takes more than 600,000 lives in the United States and 10 million globally. It’s the second-leading cause of death in America, and the rates are not going down. Despite massive fundraising campaigns and billion-dollar research budgets, meaningful innovation in cancer treatment has stalled.
In fact, most patients today are still offered the same three options they would have been decades ago: surgery, chemotherapy, and radiation.
But what if there’s more we can do to treat it? And what if we could find ways to enhance traditional treatments, all while reducing their toxicity?
At the Independent Medical Alliance (IMA), we believe it’s time to bring real innovation to the fight against cancer. That’s why Dr. Paul Marik—IMA Co-Founder and author of Cancer Care—teamed up with Dr. Justus R. Hope and created a new companion guide focused on interrupting the lethal mechanisms behind the 10 deadliest cancers. Using cutting-edge metabolic science and repurposed medicines, this guide delivers something few institutions have: a path forward.
Download the free guide, or keep scrolling for a summary written for patients and curious doctors alike.
Download PDF: Stopping the 10 Deadliest Cancers
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If you don’t mind...what symptoms led to your initial diagnosis?
Try a combination of baking soda, vinegar, and Dawn dishwashing detergent. Of course it doesn’t work, but it’s all-natural.
Unfortunately cancer will thrive over the next decade due to the bio-weapon shots.Look for it to attack many who have been shot up along with many other problems from heart to lungs to you name it.
Bkmrk
Yes . But here is the problem. It is off label. So everything is really experimental. Reddit has threads on this from people trying to work out what works best for them . You can see the wide variety.
I think genetics plays a big role
How could it possibly have my psoriasis in complete remission without taking it for months. Who knows. Maybe I cured it but I doubt it . Although it should be said I didn’t have it all over my body. just scaly patch on my leg that kept growing . Itched like crazy. Bled. Etc
Anyone trying LDN has to research to know what you are dealing with . Hard to get a script for it because many Drs don’t believe in it. My rheum Dr refuses to prescribe so I got for weight loss .
Good to know. Thanks.
Glad to hear that you’ve had a good outcome.
Due to his daughters auto-immune disease, who switched to a ‘steak only’ diet, Dr. Jordon Peterson now follows it. Modern medicine says they should be dead.
I’ve read more than once, cancer feeds on sugars...starve it.
bookmark
How Rockefeller destroyed natural cures and founded so called modern medicine!
https://substack.com/@truthtellerftm/note/c-137922267?r=pfbnl
Chemotherapy: Fraudulent and Deadly?
Comments at the bottom of the article:
“My wife, a 35 year cardiac nurse, once said to me, “You know who you never see in a hospital oncology ward? Doctors.” Enough said.”
Ha! We’ve said/asked the same thing....Notice how you never see oncologists with cancer?
A true rarity, indeed.
I’ve read more than once, cancer feeds on sugars...starve it.
Yes....one of the first directives on a serious, dedicated to health cancer protocol ... CUT OUT ALL SUGARS...minimal carbs.
The doctor you’ve had regular visits with for another problem until one day you go to someone else who found cancer, it was stage 4 and you died three weeks later?
The doctor who called two years after you died?
The doctor who refused to treat your knee because he only works on young hotties?
I’m sorry you have had traumatic experiences with doctors. My experiences are completely opposite.
BREAKING: Chemotherapy Reactivates Dormant Cancer Cells — Triggers Metastasis
https://www.thefocalpoints.com/p/breaking-chemotherapy-reactivates
New landmark study reveals that standard cancer treatment can backfire — with devastating consequences.
Nicolas Hulscher, MPH
Chemotherapy is supposed to kill cancer — not bring it back. But a groundbreaking Cancer Cell study by He et al has revealed that common cancer drugs like doxorubicin and cisplatin can reawaken dormant tumor cells, triggering deadly metastatic relapses — especially in the lungs.
These “sleeping” cancer cells, known as disseminated tumor cells (DTCs), can lie hidden for years before reactivating. This study is the first to directly prove that chemotherapy itself can wake them up.
NEW STUDY – Ivermectin Shows Striking Anticancer Potential and Remarkable Safety
Largest review to date of ivermectin use in cancer patients finds no safety concerns, promising anecdotal reports, and strong preclinical evidence of tumor suppression.
https://www.thefocalpoints.com/p/new-study-ivermectin-shows-striking
COVID-19 Vaccine is the Culprit in Majority Found Dead after Injection
https://www.thefocalpoints.com/p/covid-19-vaccine-is-the-culprit-in
Introduction: Opioid receptors are groups of receptors (γ-, κ-, δ-, and ζ-opioid receptors) that are widely distributed in nerve cells in the brain, spinal cord, and digestive tract. Naltrexone is a type of general opioid receptor antagonist. It has been used to treat chronic pain syndrome, autoimmune diseases, and cancer at a dose of 5 mg/day, which is generally called low-dose naltrexone (LDN). Objective: It was to analyze the pharmacological functions of low-dose naltrexone, especially in anti-inflammation and immunoregulation, and its therapeutic potential against cancer. Methods: The research and development of the work were carried out from June to July 2024 in the Scopus, PubMed, Science Direct, and Scielo databases, using scientific articles from the last 15 years, following the PRISMA rules. The quality of the studies was based on the GRADE and AMSTAR2 instruments, and the risk of bias was assessed using the Cochrane instrument (Funnel Plot). Results and Conclusion: Fifteen studies were included in the systematic review out of 30. Most studies showed homogeneity in their results, with X2=94.5%>50%. Low-dose naltrexone has immunomodulatory and therapeutic effects. Low-dose naltrexone regulates the production of inflammatory cytokines, influencing the level of endogenous opioid peptides in the body. Furthermore, low-dose naltrexone has an antitumor effect and can modulate the neuroblastoma tumor response, delaying the onset and reducing the incidence rate of tumors, significantly decreasing tumor volume and weight, and DNA synthesis in cancer.
“The CDC’s admission that no test can diagnose Long COVID could be a warning sign that the government has built an entire category of chronic illness on unverifiable symptoms—and failed to investigate the one factor all patients have in common: the vaccine.”
https://substack.com/home/post/p-169459844
My life insurance premium was scheduled to increase to $600/month. I requested a quote for lower coverage and a medical was required. The blood work looked awful and I was declined. I asked my GP for a re-test to confirm. My ALP and GGT numbers were very high. Indicative of liver problems. I was also extremely anemic. The only outward symptom was itching around my shoulders.
Based on the blood tests, I was scheduled for a sonogram of my liver. Initial impression was granules in my gallbladder. That prompted an MRI for better resolution. It was decided that my gallbladder needed to go. During the laparoscopic removal off my gallbladder, the surgeon dumped some "contrast" down my bile duct. It emptied slowly into my duodenum suggesting a possible blockage. An ERCP was set up. It is a transoral endoscopy that goes past the pyloric valve to investigate the duodenum. A healing duodenal ulcer was noted, but the important find was an adenocarcinoma of the Ampulla of Vater in the presence of high dysplasia. The surgeon cut away the sphincter of Oddi and inserted a stent to help the bile drain. My common bile duct looked like a gym tube sock instead of the narrow, normal tube. The bile backpressure explained the itching symptoms. A "brushing" of the tumor was delivered to pathology and determined to be malignant. That occurred April 10, 2024. The Whipple procedure was scheduled at the Huntsman Cancer Institute for June 25, 2024. There is a long line for the surgeon's services.
The short answer is it was dumb luck to get the blood test results that triggered the sleuthing resulting in a diagnosis. The itching was annoying, but that was the extent of the outward symptoms. I might well have let it go and ended up with a pancreas wiped out by the aggressive ampullary cancer.
I appreciate your detailed reply. Congratulations on your dumb luck!
It was similar dumb luck (required blood tests due to my request for higher life insurance coverage than the baseline provided by my employer) that led to the eventual discovery of aggressive prostate cancer 25 years ago.
Best of (continued) luck on your recovery.
This approach is what I normally do for any concern I or others I know might get. It takes some time (a number of hours), but the results can be inexpensive to implement and make huge differences in outcomes.
Do note I am not a doctor and I strongly encourage you to pass this by your doctors. What I am providing is just what I would do, absent a doctor's involvement. It is just meant as an illustration of the thinking and is a walkthrough of what I would want my wife and anyone else to do, absent me being able to do it (even for myself, if incapacitated). In fact, I am providing my wife with this as my most recent example to go by.
My first step was to find out the signaling pathways that start and propagate this cancer.
From “Molecular pathways in periampullary cancer: An overview” (costs $27.95 to purchase for 48 hours) [I did not purchase this, but used the abstract and snippets offered at the link as much as possible].
“Epidermal growth factor receptor (EGFR) signaling pathway
EGFR is a signaling pathway that regulates growth, survival, proliferation, apoptosis, and differentiation in mammalian cells.
WNT Pathway
The Wnt pathway has a role in cell proliferation and differentiation and is important for both normal physiological and pathological activities. This pathological growth can process into malignant tumors.
TGF-β pathway
Transforming growth factor (TGF-β) signaling pathway is involved in regulating several physiological functions including cell growth, differentiation, apoptosis, and migration. Its deregulation has been linked to cancer initiation and progression.
mTOR/AKT pathway
The Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway (PI3K–AKT–mTOR) is an important pathway that is involved in the regulation of cellular processes as survival, growth, proliferation, motility, metabolism, energy balance, stress response, and angiogenesis [78,88]). It consists of two parts: Phosphatidylinositol 3-kinase (PI3K) and its downstream molecule serine/threonine protein kinase B (PKB/ AKT) [89]. Hyperactivation of mTOR signaling has been observed…
HGF/c-MET signaling pathway
MET (c-Met), also known as hepatocyte growth factor (HGF) receptor, is a tyrosine kinase receptor (RTK) with multiple downstream effects including regulation of cell survival and migration of epithelial and myogenic precursor cells
Chromatin remodelling pathway
Switch/Sucrose nonfermentable chromatin-remodelling complexes are pleomorphic multi-subunit cellular machines that utilize the energy of ATP hydrolysis to modulate chromatin structure [106]. It is involved in regulatory cellular processes, DNA damage repair and cell cycle regulation [10] Recent genome sequencing studies have reported 20% high mutation frequency in SWI/SNF subunit genes, in all human cancers.”
https://www.sciencedirect.com/science/article/abs/pii/S0898656822002236
——————————-
I then dig into each pathway to see what can affect it from diet, exercise, and supplementation. I note the medicines along the way, but those generally are out of bounds for what we can do at home. We explore those with doctors and by giving them our original studies or authoritative web site pages.
EGFR Pathway - Other Sources
Epidermal Growth Factor Receptor Signaling Pathway is Frequently Altered in Ampullary Carcinoma at Protein and Genetic Levels
“EGFR was more commonly expressed in pancreatobiliary-than in intestinal-type tumors (p=0.002)…Similar to EGFR expression, the activation of EGFR was more common in pancreatobiliary-than in intestinal-type tumors.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC4007414/
My take: I am assuming you have the pancreatobilary form/location, as older people normally get that one. EGFR confirmation helps direct how to possibly approach addressing it with diet and such.
Abstract 129: The Microbiome Product Urolithin a Abrogates the Tgf-β Egfr Pai-1 Pathway by Inhibiting Egfr Activation and Expression
https://www.ahajournals.org/doi/10.1161/hyp.74.suppl_1.129
My take: The title directly states Urolithin A blocks this pathway. My wife and I take MitoPure Urolithin A bought off Amazon on a sale occasion, but you can buy a year's worth for less directly from the manufacturer's storefront. This is the only tested form of Urolithin A.
Targeting EGFR in Combination with Nutritional Supplements on Antitumor Efficacy in a Lung Cancer Mouse Model
“Selenium (Se) and fish oil (FO) exert anti-epidermal growth factor receptor (EGFR) action on tumors…Mice receiving the combination treatment with Se/FO and gefitinib or erlotinib had a lower tumor volume and weight and fewer metastases than did those treated with gefitinib or erlotinib alone.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC9783964/
My take: These are both normal things to get from diet or supplements—and we take these in our supplements.
This pathway appears straight-forward for the condition, but the purchase of the original study above for $27.95 would elucidate this.
WNT Pathway - Other Sources
Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
https://pmc.ncbi.nlm.nih.gov/articles/PMC7140537/
Various foods / supplements in places. It wasn't conducive to copy / paste the separate instances. Table 1 has a large list of activators and inhibitors.
My take: A number of supplements increase this pathway, including berberine, ginkgo, and seemingly, marijuana. Resveratrol, EGCG (green tea extract), quercetin, and curcumin seem to only turn it off.
I did not find a study that elaborated on a specific increase in Wnt as an enabler of this specific cancer. It looks like the “Molecular pathways” main study might tell us, if we bought it. It would be worth buying for this clarification.
TGF-β Pathway - Other Sources
Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within
“Besides induces[ing] tumor suppressive role by activation of programmed cell death, TGF-β promotes tumor suppressive role by regulating immune cell function in favour of tumor cell death (Schrantz et al., 2001). Taken together, TGF-β at the initial stage of tumorigenesis promotes tumor suppression activity, by arresting cell cycle, induces DNA damage and apoptosis is malignant cells… In the later stages of cancer, TGF-β can paradoxically result in tumor progression and metastasis (Katz et al., 2013).”
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.791272/full
My take: This is a warning, as a potentially fine line could reverse the expected outcome, based on if it is a “later stage.” Note this study does not talk to our original cancer. It looks again like the “Molecular pathways” study might tell us, if we bought it. It would be worth buying for this.
What is TGF Beta? + Factors that May Inhibit/Increase It
https://health.selfdecode.com/blog/tgf/
My take: What stage are you? This matters if you smoke or have stress (both increase TGF Beta) or take supplements or foods like resveratrol, zinc, extra virgin olive oil and others (these decrease TGF Beta). It seems strange that, if an advanced enough cancer is affected by this pathway, people are now in a place to smoke or stress out, to better control it (based on the immediately prior study), because this control for the pathway swaps, then.
mTOR Pathway - Other Sources
Selfhacked: “All About mTOR + Natural mTOR Inhibitors & Activators”
https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/
My take: There are things you can eat or take directly that curb mTOR. Diet and supplements both address its activation. You will note a couple items from the PDF above that started this whole cancer thread on this site are listed in the “Inhibitors of mTOR” subheading of the SelfHacked site, about halfway down the page, along with a number of other food or supplement options.
Because the original study at the beginning of my response specifically states “Hyperactivation of mTOR signaling has been observed…,” it seems most likely the mTOR pathway should be attacked, in my opinion, but the study should be bought for better assurance.
HGF/c-MET Pathway - Other Sources
Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy
https://onlinelibrary.wiley.com/doi/10.1002/jso.21676
My take: There is very little elsewhere on this pathway, This study is behind a paywall and appears to only look at your Whipple surgery effect on HGF. It's highly elevated for ten days, which might be from the extensive surgery, it says within. Not a help. This pathway doesn't seem to offer help, from what is publicly available. Maybe the $27.95 study better explains.
Chromatin remodelling pathway - Other Sources
Chromatin-remodeling links metabolic signaling to gene expression
“—Chromatin modifications facilitate responsive, rapid, and reversible gene expression.
—Metabolic signaling pathways, such as the TOR pathway, cooperate with chromatin-remodeling.
In addition, in ccRCC, where PBRM1 is commonly mutated, mTOR activation was found as a critical contributor to malignant transformation [28].”
https://www.sciencedirect.com/science/article/pii/S2212877820300466
I had to dig to get something helpful. This study is about this pathway and cancers, in general.
My take: Nothing else seemed to speak to pancreatobilary cancer with this pathway, in my opinion, but getting mTOR better may help this Chromatin-remodeling pathway stay sane for renal cancer (ccRCC).
Summary: I would talk with your doctor about these various study “bites” after buying and saving / printing out the “Molecular pathways in periampullary cancer: An overview” report / study.
With clarification from that purchase, the direction you could take on any pathways will be made clear. The ways to leverage the pathways are above, if the Molecular pathways report does not also state how to best utilize the pathways.
I hope this helps and I hope you are one of the ones who beats this cancer, Myrddin.
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