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Caffeine Flip-Flops a 500-Million-Year-Old Switch to Slow Aging
Scitech Daily ^ | June 26, 2025 | Queen Mary University of London

Posted on 06/30/2025 5:36:43 AM PDT by Red Badger

Caffeine sparks an ancient enzyme that helps cells survive stress and repair damage, revealing a new link between your coffee and long-term health. Credit: Shutterstock

Scientists have discovered that caffeine doesn’t just perk up your brain—it energizes your cells in a way that could slow aging.

By flipping on an ancient fuel-sensing enzyme called AMPK, caffeine indirectly taps into a powerful longevity pathway that helps cells manage stress, repair damage, and live longer.

Caffeine’s Cellular Anti-Aging Mystery Uncovered

A new study from the Cellular Ageing and Senescence laboratory at Queen Mary University of London’s Center for Molecular Cell Biology reveals how caffeine—the world’s most popular neuroactive compound—might do more than just wake you up. The study in the journal Microbial Cell shows how caffeine could play a role in slowing down the aging process at a cellular level.

Caffeine has long been linked to potential health benefits, including reduced risk of age-related diseases. But how it works inside our cells, and what exactly are its connections with nutrient and stress responsive gene and protein networks has remained a mystery—until now.

In new research published by scientists studying fission yeast—a single-celled organism surprisingly similar to human cells—researchers found that caffeine affects aging by tapping into an ancient cellular energy system.

Fission yeast is also known as “mini-human” due to its similarities with human cells.

A few years ago, the same research team found that caffeine helps cells live longer by acting on a growth regulator called TOR (Target of Rapamycin). TOR is a biological switch that tells cells when to grow, based on how much food and energy is available. This switch has been controlling energy and stress responses in living things for over 500 million years.

Fission Yeast - Fission yeast cells in which the glucose transporter Ght5 is fluorescently labelled with Green Fluorescent Protein (GFP). Credit: Olga Xintarakou, Queen Mary University of London

Ancient Energy Switches: TOR & AMPK

But in their latest study, the scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.

AMPK (AMP-activated protein kinase), is a cellular energy sensor that plays a vital role in maintaining metabolic balance. Indirect inhibition of AMPK, through the widely used anti-diabetic drug metformin, has already attracted attention for its beneficial effects.

“When your cells are low on energy, AMPK kicks in to help them cope,” explains Dr. Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study’s senior author. “And our results show that caffeine helps flip that switch.”

Interestingly, AMPK is also the target of metformin, a common diabetes drug that’s being studied for its potential to extend human lifespan together with rapamycin.

Caffeine Mechanism - How caffeine affects cells. Credit: Queen Mary University of London

Metformin Links and DNA Repair Boosts

Using their yeast model, the researchers showed that caffeine’s effect on AMPK influences how cells grow, repair their DNA, and respond to stress—all of which are tied to aging and disease.

“These findings help explain why caffeine might be beneficial for health and longevity,” said Dr. John-Patrick Alao the postdoctoral research scientist leading this study. “And they open up exciting possibilities for future research into how we might trigger these effects more directly—with diet, lifestyle, or new medicines.”

Sip Your Way to Longevity? So, the next time you reach for your coffee, you might be doing more than just boosting your focus—you could also be giving your cells a helping hand.

Reference:

“Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast”

by John-Patrick Alao, Juhi Kumar, Despina Stamataki and Charalampos Rallis, 24 June 2025, Microbial Cell.

DOI: 10.15698/mic2025.06.852


TOPICS: Food; Health/Medicine; History; Military/Veterans
KEYWORDS: aging; coffee; tcoyh
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Coffee GOOD this week!.................
1 posted on 06/30/2025 5:36:43 AM PDT by Red Badger
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To: Red Badger

It’s settled science. Get between me and my coffee only if you want to arrange a meeting with your maker.


2 posted on 06/30/2025 5:38:37 AM PDT by AndyJackson
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To: Red Badger

I don’t want to live a day over 499 million years. Oh, wait...


3 posted on 06/30/2025 5:39:20 AM PDT by NautiNurse
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To: Red Badger

With the amount of caffeine that I drink, I should live to be 1,000 years old.


4 posted on 06/30/2025 5:39:38 AM PDT by Opinionated Blowhard (When the people find that they can vote themselves money, that will herald the end of the republic.)
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To: Red Badger

Where would Europeans have obtained their caffeine prior to the importation of coffee about five hundred years ago?


5 posted on 06/30/2025 5:42:13 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: Opinionated Blowhard

A former co-worker and I have birthdays only a month apart. We were both raised in similar circumstances. He has never drank beer, wine, liquor or any alcoholic beverages, has never smoked - anything - but he does drink coffee. I am 70 and he is as well, except he looks 50................


6 posted on 06/30/2025 5:42:48 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: Red Badger

This study brought to you by Big Folgers. :)


7 posted on 06/30/2025 5:43:23 AM PDT by Lizavetta
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To: chajin

Africa. Coffee is an African plant...............


8 posted on 06/30/2025 5:43:36 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: Red Badger
Next week's study will show coffee makes your left foot grow longer than the right one. Can's have that, y'know!
9 posted on 06/30/2025 5:46:09 AM PDT by glennaro (2025: The year of America's rebirth as a Great (and Free) Republic)
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To: Red Badger

Doctors have been railing against coffee for the last few decades and now this very positive study, which I happen to agree with. My Dad always said “If you smoke, drink, and are fat, you need to find a fat Doctor who smokes and drinks.”


10 posted on 06/30/2025 5:46:41 AM PDT by Eli Kopter (ביחד ננצח הלב שלנו שבוי בעזה Together we will win, our heart is captive in Gaza.)
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To: Red Badger

Cool. Now I don’t feel worried about drinking 40 oz. a day:)


11 posted on 06/30/2025 5:47:20 AM PDT by kelly4c
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To: Red Badger

I don’t buy one word of this Chinese agit-prop that it is targeting the American public with. They are turning everything completely upside-down and doing it well.

Caffeine is an alkaloid. Just like nicotine. And is just as hazardous and deadly to your long-term health. This fact has lomg been established in Western medicine.

China is all over the internet with bullshit claims about Western foods. Deliberate subversion.

Believe this poison pen crap at your own risk. China knows the West’s weaknesses and frailties, and is exploiting them.


12 posted on 06/30/2025 5:47:53 AM PDT by 4Runner ("I gotta join a union just to get a job loafin'?" " Sure ya do!" --Abbott & Costello)
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To: chajin

Red Bull?


13 posted on 06/30/2025 5:48:20 AM PDT by Bloody Sam Roberts (Perfection is impossible. But if you pursue perfection...you may achieve excellence.)
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To: Eli Kopter

I had one of those.

But he died..................


14 posted on 06/30/2025 5:48:38 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: glennaro

So, that’s why I have a bunion on my left foot but not my right!...................🤔


15 posted on 06/30/2025 5:50:05 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: Red Badger

16 posted on 06/30/2025 5:50:13 AM PDT by SecondAmendment (The history of the present Federal Government is a history of repeated injuries and usurpations ..)
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To: Red Badger
> Coffee GOOD this week!................. <

Yep. But as you alluded to, maybe next week a study will come out showing coffee causes dangerous ear wax buildup, or some such thing. In the meantime…


17 posted on 06/30/2025 5:50:36 AM PDT by Leaning Right (It's morning in America. Again.)
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To: Red Badger

The article seems to have been written to sing the praises of Metformin.


18 posted on 06/30/2025 5:51:44 AM PDT by one guy in new jersey
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To: Red Badger
Africa. Coffee is an African plant...............

Never mind 🙄 even with my morning lunga of caffeine, my brain was thinking of chocolate coming from the new world and conflating it with coffee.

19 posted on 06/30/2025 5:53:18 AM PDT by chajin ("There is no other name under heaven given among people by which we must be saved." Acts 4:12)
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To: Red Badger

Off to the store to get more Mountain Dew 🤣


20 posted on 06/30/2025 5:53:30 AM PDT by Magnum44 (...against all enemies, foreign and domestic... )
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