Posted on 04/01/2025 2:56:45 PM PDT by ConservativeMind
A new open-source model of brain metabolism—the most complex ever generated—has shown how altering key chemicals could restore aged cells to their youthful activity and resilience.
The researchers have found that reducing blood glucose, as well as increasing blood ketone and lactate levels, could help restore metabolic function in aging brains. Potentially, these could all be achieved through lifestyle changes, including exercise and the food we eat.
The findings come from the most comprehensive computer model of brain metabolism to date, which incorporates more than 16,800 biochemical interactions between proteins and chemicals across brain cells, supporting cells, and the blood.
To understand the impact of aging on the brain's metabolism, the team included these elements in their model, which they used to compare the metabolic states of young and aged brains. In all, they calculated the impact of age-related changes on 16,800 interactions between proteins and chemicals across neurons, glia, and the blood.
The model revealed that changes in the amounts of certain molecules can have complex knock-on effects, affecting many different metabolic reactions at once. This meant the cells were more vulnerable to damage as they were less able to adapt and recover.
It also highlighted potential drug targets, as well as the potential benefit of supplementing with nicotinamide adenine dinucleotide (NAD)—a molecule that plays a vital role in the brain's energy supply. NAD-boosting supplements have been previously studied as a potential healthy aging therapy.
The discovery allowed the team to understand the complex molecular mechanisms that determine the robustness, flexibility, and adaptability of the aging brain. By altering the amounts of key chemicals, the researchers found that the aged cells could be restored back to their youthful activity and resilience.
(Excerpt) Read more at medicalxpress.com ...
“The researchers have found that reducing blood glucose, as well as increasing blood ketone and lactate levels, could help restore metabolic function in aging brains. Potentially, these could all be achieved through lifestyle changes, including exercise and the food we eat.”
Also,
“It also highlighted potential drug targets, as well as the potential benefit of supplementing with nicotinamide adenine dinucleotide (NAD)—a molecule that plays a vital role in the brain's energy supply. NAD-boosting supplements have been previously studied as a potential healthy aging therapy.“
All of this is readily available for us to do or use.
New!
Bkmk
GIGO
DEEP
I’m 88 and my MD just gave me a memory test. I;m fine. But then, I’ve been careful about my diet and exercise since I was in my 20’s. Always belonged to a gym wherever I lived. And have a few sets of dumbbells at home. I’m a small woman, so only 5, snd 8 lbs.
NAD supplements do not cross the blood-brain barrier. Any article that suggests NAD or NAD+ is helpful is suspect.
Actually, they do, but normal nicotinamide riboside does not cross well.
Liposome-based loading enhances the distribution of nicotinamide riboside chloride into the brain and its neuroprotective effects in cerebral ischemic mice
https://www.sciencedirect.com/science/article/pii/S2324242624000184
NMN crosses:
Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia–Induced Blood–Brain Barrier Disruption Through NAD+/SIRT1 Signaling Pathway
https://link.springer.com/article/10.1007/s12035-022-02903-6
I don’t believe the NAD compounds you mention are available over the counter. They certainly are not the ones that are even mentioned in cosmetics, let alone pills, which are totally merit less.
Excellent on you!!
Nicotinamide Mononucleotide (NMN) and liposomal nicotinamide riboside (NR), along with normal nicotinamide riboside, most definitely are available. I have bought them for several years, on and off.
My liposomal NR (Currently out):
https://www.amazon.com/RENUE-Liposomal-Nicotinamide-Riboside-Supplement/dp/B0BZM9T361
One liposomal NMN:
https://renuebyscience.com/products/lipo-nmn-powdered-liposomal-nmn2
There are multiple NMNH capsumes, a functional clone of NMN, also available, and here is one:
https://www.amazon.com/Dihydronicotinamide-Mononucleotide-Nicotinamide-Double-Wood/dp/B0CKCPRG5W
You can find these in some health food stores, too.
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