Posted on 04/01/2025 2:48:21 PM PDT by ConservativeMind
Past studies have shown that the human sweet taste receptor conveys sweet perception in the mouth and may help regulate glucose metabolism throughout the body. At the same time, the anti-inflammatory medications ibuprofen and naproxen are structurally similar to inhibitors of the sweet taste receptor and have been associated with metabolic benefits.
Researchers have published a study that indicates these drugs could be another way to reduce the risk of metabolic diseases.
In the team's cellular studies, ibuprofen reduced molecular signaling of sucrose and sucralose in human kidney cells made to express the sweet taste receptor. In addition, to mirror internal human physiology in the mouth, low concentrations of ibuprofen, about the same as human plasma levels after a typical dose taken at home, inhibited sweet taste and oral detection of glucose at concentrations about the same as post-meal blood sugar levels.
Long-term ibuprofen use has been associated with preserved metabolic function and reduced risk of metabolic diseases such as Alzheimer's, diabetes, and colon cancer. In addition to their anti-inflammatory properties, the team found that ibuprofen and naproxen also inhibit an important blood glucose receptor. In the team's human experiments, for example, when a participant rinses their mouth with ibuprofen, the perception of sweetness from a variety of sugars and sweeteners is reduced.
Evidence from other studies has also shown that ibuprofen and chronic disease risk reduction are intertwined. The most obvious situation, notes Breslin, is Type 2 diabetes—if you have increased blood sugar and take a lot of ibuprofen, your blood sugar decreases. The second is a decreased risk of diseases that involve glucose metabolism in specific tissues, like Alzheimer's and some cancers.
"Our study connects the two functions of TAS1R receptors as the gatekeepers of sugar intake and a downstream modulator of glucose metabolism," said Breslin.
(Excerpt) Read more at medicalxpress.com ...
Ibuprofen and naproxen blunt these receptors, blunting those responses, leading to a reduction in glucose metabolism from what would have otherwise happened. It can even reduce blood sugar, strangely.
Taking ibuprofen for long periods found to alter human testicular physiology
https://freerepublic.com/focus/f-chat/3620898/posts
Altered taste seems to be the least concerning side effect.
Bkmk
Ironically, Advil tastes sweet. Generic Ibuprofen doesn’t.
Use aspirin.
My doctor warned me that it can make your intestines bleed, which can lead to polyps.
“My doctor warned me that it can make your intestines bleed, which can lead to polyps.”
Even worse, it can cause you to bleed to death.
PS Although fatal bleeding is rare.
both ibuprofen and naproxen can increase the risk of heart attack, stroke, and heart failure, especially with prolonged use or in individuals with pre-existing heart conditions.
Ibuprofen and naproxen can both increase the risk of serious gastrointestinal (GI) problems, including ulcers, bleeding, and perforation of the stomach or intestines, and these problems can occur at any time and without warning.
ibuprofen and naproxen are both very dangerous drugs, ESPECIALLY for anyone with heart or stomach issues ...
basically, anyone with heart disease or stomach disease is playing russian roulette by taking ibuprofen or naproxen ...
Of course. He just warned that it was just enough to rupture blood vessels but not noticeable in one’s stool.
The tough part is that there are so few remedies for pain, and the medical business responded to the relatively small number of opioid abusers (vs. the much larger number of legitimate users) by making it virtually impossible for those in chronic pain to obtain something that can be effective with minimal downsides when used responsibly. I know of people who used it for years in just that manner.
My rotator cuffs are beat up and I’m sore a lot, but if I take ibuprofen it’s like I’m 20 years old again.
The problem is I know it’s bad for you so I try to only take it when the pain is pretty bad.
I recently had a hernia surgery and I took a bunch of ibuprofen for about 10 days after and it was like there was nothing wrong with my shoulder.
It’s extremely rare to cause bleeding and the advice not to use it after surgery is hyper cautionary for most people. I know. Had two surgeries were I was told to not use ibuprofen or naxapropene because they may cause bleeding. After reading research found here I figured the possibility was remote and that the docs were just parroting the warnings with no thought to real life probabilities.
Since both surgeries involved much swelling and inflammation I took Aleve anyway. No problem either time and it was far better than OxyCo. Later the doc said that he has never seen a problem with it but he’s not allowed to recommend it.
Ping
So, are you willing to trade your soreness for kidney failure and potentially dialysis??
Having spent three years on dialysis is something I know a little about. Trust me it ain't worth it.
“Having spent three years on dialysis is something I know a little about. Trust me it ain’t worth it.”
Was your kidney failure caused by NSAIDs? If so, what dosage and for how long?
In my family, everyone feels that way about Tylenol (it causes pain in the digestive tract, sometimes severe pain lasting for days). It was noticed about 40 years ago and now, we all know it's best to avoid the stuff. Most doctors and nurses seem surprised when they are told, no Tylenol thank you!
I had an issue that caused me to over-use naproxen. I ended up with bloody urine.
I’m leaning away from those types of drugs.
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