Posted on 03/18/2025 4:16:57 PM PDT by ConservativeMind
The herb rosemary has long been linked with memory. So it is fitting that researchers would study a compound found in rosemary and sage—carnosic acid—for its impact on Alzheimer's disease.
Carnosic acid is an antioxidant and anti-inflammatory compound that works by activating enzymes that make up the body's natural defense system. Scientists have now synthesized a stable form, diAcCA. This compound is fully converted to carnosic acid in the gut before being absorbed into the bloodstream.
The research showed that when diAcCA was used to treat mouse models of Alzheimer's disease, it achieved therapeutic doses of carnosic acid in the brain and led to enhanced memory and synaptic density, or more synapses in the brain. Because the decline of neuronal synapses is also closely correlated to dementia in Alzheimer's disease, this approach could counteract the progression of cognitive decline.
Analysis of tissue samples showed the drug also markedly decreased inflammation in the brain. This unique drug is activated by the very inflammation that it then combats and thus is only active in areas of the brain undergoing inflammatory damage.
"We actually increased the number of synapses in the brain," says Stuart Lipton, MD, Ph.D. "We also took down other misfolded or aggregated proteins such as phosphorylated-tau and amyloid-β, which are thought to trigger Alzheimer's disease and serve as biomarkers of the disease process."
Lipton's group treated mouse models with the compound over the course of three months.
"We did multiple different tests of memory, and they were all improved with the drug," Lipton says. "And it didn't just slow down the decline; it improved virtually back to normal." Analysis of tissues also showed increased neuronal synaptic density and decreased formation of phosphorylated-tau aggregates and amyloid-β plaques.
The mice tolerated diAcCA well.
(Excerpt) Read more at medicalxpress.com ...
NOT the same thing ...
AI Overview
Carnosic acid and carnosine are both antioxidants, but carnosic acid is a natural benzenediol abietane diterpene found in rosemary and sage, while carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine.
Carnosine is produced in the liver ... carnosic acid is derived from plants ... rosemary and sage.
Has to be “Gardener”...”Symbol for an Empire” already used!
Not D Cert material, but available Epitaphs: “Fond Daughter of Wisconsin” Or “Diana in the Driftless”. or your proud proclamation! “Red Head Said “My Garden Kicked Ass!”” :O
***In the last photo of Eliz. Regis note the Bearskin cap of the Black Watch pall bearer lower right. (Sourced from Canadian black bear for now.)
L.J. It sounds like we all do!
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