Posted on 03/13/2025 3:44:12 PM PDT by ConservativeMind
An international study has revealed that melatonin, known for its ability to regulate the sleep/wake cycle, can restore the composition of muscle fibers and protect skeletal muscle from damage caused by obesity and type 2 diabetes, known as "diabesity."
The results show that this hormone improves mitochondrial function, reduces cellular stress and prevents programmed cell death, offering a new therapeutic strategy.
The study showed the administration of melatonin to obese and diabetic rodents for 12 weeks succeeded in promoting the conversion of glycolytic (fast) muscle fibers to oxidative (slow) fibers, improving the energy efficiency of the muscle. This change not only optimizes energy production, but also protects the muscle from deterioration caused by "diabesity," a condition that combines obesity and type 2 diabetes.
Muscle fibers are divided into three types: slow twitch (type I) or red fibers due to the large number of mitochondria they possess, fast twitch (type IIb) or white fibers and intermediate (type IIa). In addition, each muscle in our body has a specific variable and changing proportion of each of these fiber types, depending on the type of movement performed. During short periods of intense muscular activity, white fibers with glycolytic metabolism predominate, and during prolonged periods of low-intensity muscular activity, red fibers with oxidative metabolism predominate.
Melatonin managed to restore the healthy proportion of these fibers, increasing oxidative fibers and reducing glycolytic fibers, reversing the effects of "diabesity," which improves the muscle's ability to burn fat and produce energy. In addition, melatonin showed effects similar to those of prolonged aerobic activity, especially improving mitochondrial function and regulating calcium levels in cell compartments, which reduces cellular stress and prevents programmed cell death.
"We discovered that melatonin restores calcium levels in the mitochondria and the endoplasmic reticulum, which helps to reduce cell damage," says Dr. Agil.
(Excerpt) Read more at medicalxpress.com ...
so it is a choice between being strong but asleep all the time
or
being a weakling but awake to take the abuse?
smiles
I gotta think this one over a bit...
smiles
Take it before sleeping and be done with it.
I’ve used Melatonin for years. It doesn’t make you ‘sleep all the time’, or make you groggy in the morning. It just helps you to fall asleep.
(Can give you very interesting dreams, too.)
Interesting dreams? I’ve found the opposite. I used to dream coherent stories that I wish I could have written down. Since I began taking melatonin to help me fall asleep two years ago, I’ve almost entirely stopped dreaming.
My wife takes 5mg with no issues.
I should have added that pistachios are one of the highest natural sources of melatonin. Lately I’ve been eating 10g which helps sleeping without morning issues.
BTTT
This is racist. Blacks are born with melatonin right on their body. I have to go buy the stuff and then it may not work. I have the worst luck.
I take 10mg of Melatonin along with 5,000 iu of D3 and 50 mg of K2 every night right before bed.
I've tried it in various doses and it does nothing for me
I take 10mg of Melatonin along with 5,000 iu of D3 and 50 mg of K2 every night right before bed.
There is remarkable difference in sensitivity to melatonin. To find a tolerable dose (one that induced sleep but didn’t make me feel groggy/depressed/dizzy the next day) I kept reducing my intake to where I finally got to .25 mg (sublingual). That seemed like an absurdly small amount until I read that a young, healthy person produces 10-80 (micro)grams per night internally.
I guess people are different in their reactions to it.
That’s odd. A lot of people complain that it makes their dreams TOO vivid. I’ve always dreamed and remembered my dreams; melatonin just enhances that. Maybe you should try a lower does?
D3 and K2 should be taken with, or after, a meal containing fat. They are fat soluble, and you need to have fat in your gut to assimilate them properly. Don’t wait too long after your meal to take them.
“Blacks are born with melatonin right on their body”
Maybe melanin?
Sometimes before bed I take 1/4 of a 10mg tablet, but not as often as I used to. I connected them to UTIs so cut way back.
LOL!
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