Metastatic bladder cancer immunotherapy outcomes better with antihistamines, study shows (Tecentriq reduces death by 41+%)

Medical Xpress / University of Cincinnati / Urologic Oncology: Seminars and Original Investigations ^ | Feb. 20, 2025 | Tim Tedeschi / Giuseppe Fallara et al

[ConservativeMind]

Research led by Alberto Martini, MD, that found using antihistamines in patients receiving second-line immunotherapy (IO) for bladder cancer may improve outcomes.

The research focused on metastatic urothelial carcinoma (mUC), cancer that begins in the urothelial cells, which line the urethra, bladder, ureters and some other organs. Martini, served as corresponding author of the study.

Using data from two clinical trials, the researchers identified 896 patients who were treated with second-line IO drug atezolizumab. Out of those patients, 155 patients received concomitant antihistamines and 741 did not.

Antihistamine users had 41% lower risk for all-cause mortality, 42% lower risk for cancer death and 30% lower risk of cancer progression compared to patients that did not receive antihistamines.

"Our results show a positive association between the use of antihistamines and oncologic outcome in patients with mUC treated with IO," Martini and colleagues concluded.

[ConservativeMind]

If being treated for bladder cancer, adding in a prescription for the antihistamine atezolizumab (Tecentriq) had a 41% lower risk for all cause death and a 42% lower risk of cancer death than those not getting it.

I would tell your doctor about this study, if affected.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Irish Eyes]

Bookmark

[HighSierra5]

I went through immunotherapy for my liver last year. It dang near killed me. I never felt so bad in my life. The oncologist said that he was going to discontinue the therapy but I stopped it about a week before. It took until last January to feel normal. So far the tumor has shrunk and my bloodwork shows hardly any cancer plus my liver and kidney functions are normal. All I can say is that I’m not going through that again.

[aquila48]

Bookmark

[Candor7]

Bladder Cancer Ping