Posted on 01/16/2025 7:32:16 PM PST by ConservativeMind
Researchers have provided the molecular explanation for why some osteoporosis drugs offer protection against COVID-19.
The study builds on work that compared more than 450,000 users of a class of drugs, called bisphosphonates, with non-users during the months leading up to the pandemic in 2020.
The Harvard study showed that those who used drugs, such as alendronate and zoledronate, had lower odds of testing for SARS-CoV-2 infection, COVID-19 diagnosis and COVID-19-related hospitalization, but the study didn't explain why.
Researchers explored all bisphosphonates listed in a drug candidate database that could potentially bind to a specific enzyme domain found in nidoviruses, which are a group of viruses that includes coronaviruses.
The researchers applied this technique to the top candidates in a drug repurposing database, called "CoviRx," and after analyzing the data, the researchers narrowed down their selection to two compounds were found to be similar to already approved drugs, minodronate and zoledronate.
They showed that alendronate is also similarly promising, suggesting all three could be potential candidates for further research and clinical trials.
Professor Seshadri Vasan, said, "Although vaccines have proved effective against COVID-19 and its variants, they are not able to prevent their transmission, and so new drugs are being sought to keep pace with the continuously mutating virus.
"One approach to this challenge is to use drugs already in-use for other conditions, and so in 2023 we released a database of drugs that allows scientists to narrow their search from a list of 7,817 potential candidates to a 'top 214.' We also screened 1,992 bisphosphonates in another public database.
"Using this approach we were able to provide a molecular explanation for osteoporosis drugs such as alendronate and zoledronate protecting against COVID-19, and predict that other molecules like minodronate, a drug used in Japan, may also be beneficial."
(Excerpt) Read more at medicalxpress.com ...
“Professor Seshadri Vasan, said, "Although vaccines have proved effective against COVID-19 and its variants, they are not able to prevent their transmission, and so new drugs are being sought to keep pace with the continuously mutating virus.”
We all knew the vaccine could not prevent infection, despite the lies offered by Fauci and Birx. It’s nice to see people with the actual real science call this out again.
Agreed. I hope more stuff like this continues to come out.
99%+ survivable for people without comorbidities.
Oh wow! This is great! Only 4 years into the pandemic that is killing millions every day!
Yeah . . no they weren't. A recent study in Japan showed they actually had a negative efficacy effect. IOW, they increased your odds of getting Covid (by 84%). The more shots, the greater the chances of getting again. Two studies one with a smaller group and one considered a mid sized study group comparing those with Covid shots and the control group. Consistently the vax didn't have a positive outcome. Of course this won't be released in MSm (who have been either bought off or afraid to speak out).
Also this has been my experience with my in-laws who did take the vaccine (more than once) they repeatedly got Covid over and over and were mad about it. But never said anything bad about the vaccine.
I’m skeptical about their claim that the vaccines were effective against Covid.
And because of that, I’m skeptical about their claims that these drugs may help, too.
Additionally, they’re still acting as if Covid were some kind of danger than ordinary cold or flu viruses weren’t.
I was also thinking of that. But did they advise people to lose weight?
Nope.
Instead they demanded we do the very thing that was the worst possible decision. Demand people stay home and indoors.
And recommended by the same medical community that recommended using that poison Remdesivir.
I’m trying to figure out why I should trust their claims on this one.
90% of the advertising revenue for network news is "Brought to you by Pfizer."
Oh, how I long for the good old days, back when I had zero ‘co-morbidities’! That might have been back in the first Reagan Administration. I was in the Navy.
Don’t trust them! My osteoporosis is very advanced now, but I’m 84 so to be expected. Doctors tried 10 years ago to get me to take Fosamax, but I had just had oral surgery and knew it would lead to jaw necrosis in me. Thank God I refused it. Fosamax is deadly.
Many years ago when I was going through menopause, and been diagnosed with osteopenia, I was put on Actonel, and told to take 50,000 units of Vitamin D once a week. At some point my bloodwork alarmed the P.A. at my Gastroenterologist's office. She asked me if I drank a lot of alcohol, which I didn't. She ordered a sonogram on my liver because she feared I had liver cancer. There was no cancer. She told me to stop taking the Actonel as she believed it was causing my liver enzymes to be out of whack. Once I stopped it, my liver enzymes went back to normal, and have been normal all these years. I'm 77 now. I also had to stop taking Vitamin D, because it turns out I have a hyper parathyroid, and it produces more calcium than I need. My calcium numbers are always high.
About two years ago, my Endocrinologist/Family Doctor wanted to put me on Fosamax as I now have patches of Osteoporosis. I told him about the problem I'd had with Actonel. Both meds are in the same drug classification. I took it for maybe a month, when my doctor changed two of my other meds: Prevastatin and Lisinopril, to Atorvastatin and Lisinopril with Hydrochlorothiazide. At the time he prescribed the Lisinopril with Hydrochlorothiazide, I advised him that I had been told to stop taking Hydrochlorothiazide back in 2015 after being hospitalized for very low levels of sodium, magnesium and potassium. He told me the amount in the new pill shouldn't cause a problem. However, within a week of taking the two new medications along with the Fosamax, my urine had turned orange, I felt weak, fatigued, shaky, had loss of appetite, and I had problems controlling my blood sugar. My doctor sent me for bloodwork, and everything he tested was either too high, or too low. Nothing was in the normal range. I stopped taking all three of the medications right then and there, because I knew it was the combo of one, two or all three meds that had brought on the symptoms.
When I went back to see my doctor, I told him I had stopped all three. He put me back on the Pravastatin and Lisinopril. When he asked about the Fosamax, I told him I would just deal with the Osteoporosis on my own. It took me 6 weeks to finally start feeling better. Thankfully, my Endocrinologist/Family Doctor retired that December, and I have since found a new family doctor and a new Endocrinologist that I like much better.
Mr m m had osteoporosis, as verified by a hip fracture and bone density scan.
They wanted him on Fosamax and he took it for a few weeks but didn’t like the side effects and the long term ones listed, so he went off it.
By eating better, exercising, and lots of Vitamin D, he’s managed to completely reverse it. His bone density scan
All without some poison from big pharma.
No vaccine has ever been able to prevent infection, no matter what the disease is. They just train your immune system to make antibodies against the disease before you get exposed to the real thing.
The process is no different than how you develop natural immunity, which also offers no guarantee that you won’t get infected again.
If a big enough percentage of the population gets immunized then herd immunity comes into play and some diseases can die out. This works best with viruses that have no animal reservoir such as smallpox and polio. In the case of Covid all variants with the original spike protein died out within a year of the vaccine release. The strains continuing to circulate are derived from the Omicron spike which immune systems trained by the 2021 vaccines don’t recognize.
Thank you for detailing your experience! It was an Endocrinologist who tried to force me onto Fosamax, too. He even threatened me, intimidating I’d have a stroke and/or be in a wheelchair in 5 years. That was about 12 years ago, I think. We CAN deal with Osteo on our own..
Wow!! What a horrible doctor. At least my Endocrinologist was older, and wasn’t a bully. I’d been seeing him for over 20 years at the time.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.