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New research links vagus nerve stimulation to reduced gut inflammation in mice (Helps IBD)
Medical Xpress / Duke University / Science Translational Medicine ^ | Nov. 20, 2024 | Ayman Youssef et al

Posted on 12/10/2024 3:54:25 PM PST by ConservativeMind

Researchers have found that tapping into the nervous system could help reduce the gut inflammation that drives inflammatory bowel disease (IBD).

A new study reveals how electrical stimulation of the vagus nerve—a major nerve connecting the brain and gut—may combat the stress-related inflammation that worsens IBD symptoms.

The study showed that vagus nerve stimulation in stressed mice with colitis, a form of IBD, reduced inflammation, improved symptoms, and boosted survival rates. By engaging the parasympathetic nervous system, the team observed that inflammation could be eased by inhibiting SUMOylation, a cellular process that shapes immune response.

Ayman Youssef, MD, analyzed data identifying that inhibiting SUMOylation, through genetic or drug-based approaches, dramatically slowed disease progression in mouse models.

IBD cases are soaring—up 50% in the last 15 years. Scientists are intensifying efforts to reduce inflammation-causing cells in the intestines and improve treatment options for the nearly 7 million people affected worldwide.

IBD includes two primary types: ulcerative colitis, which affects the colon; and Crohn's disease, which can inflame any part of the digestive tract. Both conditions disrupt lives and can lead to serious complications like colon perforation, cancer, and even early mortality.

Current anti-inflammatory treatments bring relief but often fall short, as patients can lose their response to these medications over time, suffer relapses, and experience significant side effects.

Researchers have long noted that stress plays a significant role in exacerbating IBD symptoms, and some have even described ulcerative colitis as psychosomatic.

"Stimulating the vagus nerve neutralized the effects of stress and restored a balanced and healthy physiologic state," said Ulloa, a Duke researcher, the leading and corresponding author of the study. "Many relaxation techniques, like deep breathing and meditation, are designed to enhance the parasympathetic system, with the vagus nerve playing a central role in relaxing most of our organs.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: gitract; gut; ibd; inflammation; medicalxpress; vagus; vagusnerve
Relaxation techniques can help the parasympathetic system, which engages the vagus nerve. This, in turn, can, perhaps strangely, help address IBD.
1 posted on 12/10/2024 3:54:25 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 12/10/2024 3:54:52 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Hey, this is a family friendly website!


3 posted on 12/10/2024 4:07:26 PM PST by monkeyshine (live and let live is dead)
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To: All
I got the nerve to go to Vegas and improve my fortune. I bet big and lost it all.


4 posted on 12/10/2024 4:12:44 PM PST by BipolarBob (Enough of this talk about narcissists, let's get back to talking about me.)
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To: ConservativeMind
This corresponds with a suggested benefit of the Wim Hof Method, which is reported to "reset" the vagus nerve.
5 posted on 12/10/2024 4:15:19 PM PST by Carry_Okie (The tree of liberty needs a rope.)
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To: BipolarBob

My experience is that you can stimulate a woman’s vagus nerve by rubbing her bottom.

I’ve also learned that you should introduce yourself first.


6 posted on 12/10/2024 4:24:55 PM PST by Larry Lucido (Donate! Don't just post clickbait!)
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To: ConservativeMind; CottonBall

There are tons of you tube videos online that show techniques for vagus nerve stimulation.


7 posted on 12/10/2024 4:43:19 PM PST by metmom
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To: ConservativeMind

There are devices you can buy that stimulate the vagus nerve. Not sure if they’re worth it as they’re not cheap


8 posted on 12/10/2024 4:46:07 PM PST by spacejunkie2001
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To: ConservativeMind

Valerian root stimulates the vagus nerve.

I recommend fresh plant tincture over dried Valerian root.


9 posted on 12/10/2024 6:46:29 PM PST by TigersEye (If you voted for Kamala you're a squirrel murdering communist!)
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To: Larry Lucido

That sounds a lot like putting an alligator to sleep by putting it on its back and rubbing its belly.

Putting the alligator on its back is where the right introduction is key I imagine.


10 posted on 12/10/2024 6:49:50 PM PST by TigersEye (If you voted for Kamala you're a squirrel murdering communist!)
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To: ConservativeMind

Bkmk


11 posted on 12/10/2024 6:51:30 PM PST by sauropod ("You didn't take a country. You only won a football game!" - Dan Dakich Ne supra crepidam)
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To: BipolarBob

Emily…Emily…it’s vagus. Vagus, not Vegas.


12 posted on 12/10/2024 7:15:53 PM PST by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: Carry_Okie

BTTT


13 posted on 12/11/2024 12:10:45 AM PST by nopardons
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To: ConservativeMind
C.M. Thanks for this discussion! Some links showing easy physical techniques discuss techniques that may help with calming. (Without plunging into a freezing lake.) Some involve sound, some things like pressure points manipulation or tapping. (Of course, giving up the standard American diet full of seed oils and sugars for a healthier Mediterranean Type diet would be helpful too.) Western Doctors:

Should-you-be-toning-your-vagus-nerve

vagus-nerve-stimulation-9-ways-to-quickly-calm-body-and-soul

How Tapping These Points Can Change Your LIFE! Dr. Mandell

Buddist Monk: PRESS THESE 3 POINTS DAILY for A Healthy Life | Qigong Basic Acupressure Daily

14 posted on 12/11/2024 6:50:28 AM PST by Pete from Shawnee Mission
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