Posted on 11/30/2024 2:57:58 PM PST by ConservativeMind
The treatment landscape for patients with prostate cancer, especially individuals with advanced disease, has dramatically changed in recent years. However, aside from drug or hormonal therapies, other targets to treat prostate cancer are still necessary to prolong life and slow the progression of this potentially lethal disease.
A study found inhibition of the sterol regulatory element of binding (SREB) can reinduce sensitivity to the drug docetaxel, commonly used to treat prostate and other cancers. These findings show promise to improve the efficacy of docetaxel-based chemotherapy in patients with prostate cancer.
Combining docetaxel with second-generation hormonal therapy is a novel treatment approach, with recent studies showing improved progression-free and overall survival. However, the efficacy of chemotherapy is restricted by the development of therapy resistance, which represents a significant limitation in clinical practice.
Investigators performed RNA sequencing in docetaxel-resistant prostate cancer cell models after treatment with a combination of docetaxel and mifepristone. This treatment significantly reduced cancer cell viability. RNA sequencing revealed sterol regulatory element of binding transcription factor 1 (SREBF-1), a transcription factor of cholesterol and lipid biosynthesis, as a significantly down-regulated target. This is a central cellular regulator involved in docetaxel-resistant prostate cancer.
Specific Inhibition of cholesterol and lipid biosynthesis reinduced sensitivity to docetaxel. Furthermore, researchers were able to show that SREBPs are increasingly expressed in metastatic prostate cancer, which they found in a specific tissue microarray from tumor tissue from advanced prostate cancer patients.
Martin Puhr, Ph.D. notes, "Our results support the idea that SREBPs are essential regulators of cell survival and susceptibility to docetaxel in advanced and metastatic prostate cancer, affecting prostate cancer aggressiveness and docetaxel resistance.
"Our data provide further evidence that inhibiting cholesterol and lipid biosynthesis might provide a clinically meaningful rationale for increasing the efficacy of prostate cancer therapies and in specific, drug-resistant prostate cancer."
(Excerpt) Read more at medicalxpress.com ...
Yes, mifepristone is part of RU-486.
I would imagine in the coming years/decades, great advances will be made in cancer treatements due to Ai, of course all depending upon whether or not Biden decides to kick off WW3 before he leaves office
Well I did the harmon and radiation treatment for my prostate cancer in 2016. So far so good. So Biden and WWIII will really screw up my long term recovery plan. Anyway be safe and have a Happy Thanksgiving.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3426621/
It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.
Drink Green Tea as well. Have a "supportive" wife.
https://www.urmc.rochester.edu/news/story/a-good-marriage-and-green-tea-might-help-fight-pro
In two unrelated studies, Rochester researchers investigated prostate cancer with results pointing to the benefits of strong support at home and sipping green tea.man with tea cup
The green tea investigation, led by Thomas A. Gasiewicz, Ph.D., chair of the Department of Environmental Medicine, shows why green tea extract (the main component being epigallocathechin gallate or EGCG) might have anti-cancer properties, particularly for late-stage and metastatic prostate cancer. Although green tea has been investigated for years, the Rochester team believes this is the first study to offer a unifying hypothesis for a mechanism whereby EGCG has anti-cancer activity.
The study is published in Cancer Research Prevention. It also reports that green tea’s anti-cancer activity is likely due to its effect on a protein pathway known as HSP90 (heat shock protein 90), which has an important role in cancer progression. Researchers believe that understanding this link may lay the foundation for developing a type of green tea analog that can target the function of HSP90 with few side effects.
The second study, published in the Journal of Cancer Survivorship by lead author Gary R. Morrow, Ph.D., M.S., shows that married prostate cancer survivors with a high level of partner support reported much less psychological distress than unmarried survivors or those with low levels of partner support.
The implication for physicians: it’s important to assess and consider marital status and partner support when evaluating a patient’s psychosocial functioning, when deciding on an intervention, or when trying to better understand factors that impact survivorship and quality of life.
Make tea with green tea and ginger. Have your Japanese wife make it for you!
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