Gut microbes play key role in regulating stress responsiveness throughout the day, research finds

Medical Xpress / University College Cork / Cell Metabolism ^ | Nov. 5, 2024 | Gabriel Tofani et al

[ConservativeMind]

A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms.

The findings open the door for developing new microbial-based therapies that could help individuals better manage stress related mental health conditions, such as anxiety and depression which are often associated with alterations in circadian and sleep cycles.

This breakthrough research offers compelling evidence that the trillions of microorganisms in the gut orchestrate the body's hormonal responses to stress in a time-dependent manner, paving the way for new therapeutic approaches targeting the gut-brain axis.

This study shines a spotlight on the intricate relationship between the gut microbiota and the hypothalamic-pituitary-adrenal (HPA) axis, the body's central stress response system.

The research demonstrates that depletion of gut microbiota leads to a hyperactivation of the HPA-axis in a time-of-day specific manner, which, alongside alterations to the brain's stress and circadian responding regions, results in altered stress responsivity across the day.

The study further identifies specific gut bacteria, including a Lactobacillus strain (Limosilactobacillus reuteri), as key influencers of this circadian-regulated stress mechanism. L. reuteri emerged as a candidate strain that modulates glucocorticoid secretion (stress hormones), linking the microbiota's natural diurnal oscillations with altered stress responsiveness.

This discovery opens up new possibilities for psychobiotic interventions aimed at improving mental health outcomes by targeting gut bacteria that influence stress regulation.

With modern lifestyles increasingly disrupting circadian rhythms through irregular sleep patterns, high stress, and poor diet, this research underscores the importance of the gut microbiota in maintaining the body's natural stress-regulation processes.

Professor John Cryan said, "The gut microbiome doesn't just regulate digestion and metabolism; it plays a critical role in how we react to stress, and this regulation follows a precise circadian rhythm."

[ConservativeMind]

Reuteri is available by itself or with complexes, in supplement form, and in a a couple kefirs and yogurts.

They call this one out for helping with stress management.

[ConservativeMind]

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[MayflowerMadam]

“Reuteri is available by itself”

Pills? (Can’t do yogurt.)

TY

[Ronaldus Magnus III]

In other news, Kamala Harris’ gut microbes have developed the ability to make her laugh and cackle in response to....well....most everyone and everything. Rumors that Harris’ gut microbes first developed in the Cackler In Chief, Billary Rodham, such rumors have not been substantiated by Dr Fauci.

[waterhill]

Wife and I ran around LA this past weekend eating all kinds of things. Our road snacks were kimchee and jerky. We kept the windows cracked to give the dogs some fresh air.

[Veto!]

Lots of pills. Just look at AMZ.

My microbiome is in great shape. Eat yogurt with fruit in it almost every night for dessert. Also drink yummy Kombucha. Both loaded with probiotics. Kombucha available in all our local stores. It comes in many flavors, some sweet, some tart. You’ll find one you like.

I’ve lived here for 16 years. Had a cold 10 years that lasted 5 days. Handled it with OTC antihistamine and Mucinex. No cold since then. My very smart MD didn’t think I needed a Covid shot. (I’m 88, weigh 112.)

[kelly4c]

Interesting and good information. Bookmark.

[DallasGal]

I think many chronic things stem from poor gut/metabolic health. Interesting article

[metmom]

I found this article about psyllium husk powder and its effects on the gut.

I thought it might be of interest to the ping list.

Psyllium Husk Positively Alters Gut Microbiota, Decreases Inflammation, and Has Bowel-Regulatory Action, Paving the Way for Physiologic Management of Irritable Bowel Syndrome

https://www.gastrojournal.org/article/S0016-5085(23)05241-1/fulltext