Stereotactic body radiotherapy viable alternative for localized prostate cancer (1/2 the radiation)

Medical Xpress / HealthDay / New England Journal of Medicine ^ | Oct. 17, 2024 | Lori Solomon / Nicholas van As et al

[ConservativeMind]

Stereotactic body radiotherapy (SBRT) is noninferior to conventional or moderately fractionated radiotherapy for localized prostate cancer (PC), according to a study.

Nicholas van As and colleagues assessed whether SBRT is noninferior to conventionally or moderately hypofractionated regimens in patients with localized PC. The analysis included patients randomly assigned to SBRT (36.25 Gy in five fractions over one or two weeks) or control radiotherapy (78 Gy in 39 fractions over 7.5 weeks or 62 Gy in 20 fractions over four weeks).

The researchers found that at a median follow-up of 74.0 months, the five-year incidence of freedom from biochemical or clinical failure was 95.8% in the SBRT group and 94.6% in the control radiotherapy group (unadjusted hazard ratio for biochemical or clinical failure, 0.73; 90% confidence interval, 0.48 to 1.12; P = 0.004 for noninferiority).

The cumulative incidence of late Radiation Therapy Oncology Group (RTOG) grade ≥2 genitourinary toxic effects at five years was 26.9% with SBRT and 18.3% with control radiotherapy (P < 0.001). For RTOG grade ≥2 gastrointestinal toxic effects, the cumulative incidence was 10.7% and 10.2%, respectively (P = 0.94).

"Five-fraction SBRT is a robust and viable alternative to moderately fractionated radiotherapy for prostate cancer, offering equivalent efficacy with enhanced convenience for patients," the authors write.

[ConservativeMind]

Stereotactic body radiotherapy (SBRT) uses a fraction of the normal radiation and provides the same benefit (in this study, it is slightly better efficacy, too).

However, it appears there was a sizable likelihood increase of urinary retention, incontinence, or blood issues (26.9% vs 18.3%) for this lesser overall radiation (but higher single visit radiation).

SBRT requires only five visits, it appears, instead of up to 39 visits.

[ConservativeMind]

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[TexasGator]

Moffitt Cancer Center Tampa:

Potential SBRT side effects

As was noted above, when compared to conventional radiation therapy, SBRT often produces fewer and milder side effects.

[grobdriver]

Bookmark.

[Pontiac]

Chinese study shows Ivermectin effective in causing cancer cell death.

https://rumble.com/v5jf4yd-ivermectin-and-cancer.html?e9s=src_v1_ucp

https://www.sciencedirect.com/science/article/pii/S1043661820315152

[Salvey]

A friend of mine had SBRT for prostate cancer, about twenty years ago, and has been in remission ever since. Five short treatments. Zero PSA reading. No bleeding, no ED, no incontinence.

[ASOC]

Finished my radiation treatment (5 sessions over two weeks) in Sept. The side effects were unpleasant, but short duration.

I caught mine early enough that I expect to be cancer free up to the day I check out.....

[DennisR]

I finished a 28-day regimen of proton therapy for prostate cancer the first week of August. During the treatment, my only symptoms were having to get up to pee several times each night and diarrhea. Both of these have been pretty much resolved, and one month after treatment, my PSA was 0.03.

I have also been on androgen deprivation therapy (ADT_ since the first week of May. Apart from the normal, obvious side effects with having practically no testosterone, I feel the same strength and energy as before I started the ADT.

For some reason (maybe because I had a Gleason score of 9 at one particular location in my prostate), the oncologist did not recommend SBRT.