Posted on 10/02/2024 9:04:44 PM PDT by ConservativeMind
Breast cancer is one of the most common cancers in women, with high rates of mortality and morbidity. According to a study, scientists have revealed a new function of ganoderic acids from Ganoderma lucidum (G. lucidum) for treating breast cancer.
This is the first time scientists identified potential targets of ganoderic acids for breast cancer treatment using bioinformatics techniques.
G. lucidum, also called as Lingzhi in Chinese, is a popular medicinal fungus. It has a unique therapeutic and pharmacological reputation in suppressing cancer/tumor progression, especially breast cancer, due to its embedded rich bioactive chemical constituents, mainly triterpenoids (ganoderic acids).
In this study, a team led by Prof. Huang Qing applied network pharmacology analysis to predict the potential therapeutic targets and signaling pathways of ganoderic acids for breast cancer treatment.
Their results showed that 53 potential target proteins associated with 202 pathways were predicted to be related to breast cancer. Further analysis narrowed these targets down to six key candidates, which were validated through molecular docking studies.
Specifically, ganoderic acid DM (GADM) and the target with the strongest interactions, were validated via breast cancer cell lines. The more GADM they used, the more it suppressed PIK3CA protein in breast cancer cells, the researchers found.
These findings suggest that GADM could be a reliable potential treatment for breast cancer by inhibiting PIK3CA and slowing cancer cell growth. This positions GADM as a potential candidate for combination therapies aimed at enhancing current treatment methods or overcoming drug resistance.
The findings provide a strong rationale for further exploration of GADM as a potential therapeutic agent for breast cancer, according to the team.
(Excerpt) Read more at medicalxpress.com ...
Grows all at the woods’ edge here.
Not a believer in magical discoveries that have been around just waiting for someone to try. I think those days are 50 to 100 years in the past. The level of understanding is very much higher now and the mechanisms of function of whatever is being tried is understood. And of course there is the reality that if something bizarre like willow tree bark is found to have some benefit, whatever the mechanism is will be learned and synthesized and it won’t come from tree bark anymore.
That being said, breast cancer is pretty ugly. It has a remarkably frequent bit of behavior that is apparent complete remission and disappearance and then recurs again after a significant period of time. Psychologically that’s much worse than just grinding along the same amount of time with no remission. The behavior generates hope and then crushes it.
One other item worth noting. There’s no reason to believe that a major breakthrough cannot come from Chinese research. They do quality work just like any other first world country.
Interesting......thanks for the article.
Bkmk
https://www.msn.com/en-us/health/other/honeybee-venom-can-kill-breast-cancer-cells-in-under-30-minutes-new-study-finds/ar-AA1qFTn7?ocid=msedgntp&pc=HCTS&cvid=6dc24b1cf83d4f809f81c463efd3dfca&ei=137
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