Posted on 09/18/2024 12:01:06 PM PDT by ChicagoConservative27
Metformin is the most common type 2 diabetes drug prescribed to millions of American each year, and a new study from researchers at the National Institutes of Health (NIH) published in Diabetes Care suggests the drug can lower the risk of developing long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), in diabetics.
Metformin lowers blood sugar and is most commonly prescribed as a first-line treatment for type 2 diabetes. The drug also is prescribed off-label for weight loss and other metabolic conditions.
The new findings come from the ongoing RECOVER trial and build on results seen in a 2023 trial, which showed metformin cuts the risk of long COVID by 40% in 1,300 adults who were overweight or obesity. Those participants were not diabetic.
75,000 adults studied In the new study, the authors wanted to see if that effect was still seen in those taking metformin for diabetes. Previous studies have shown that people with type 2 diabetes are more at risk for developing long COVID
The investigators used electronic health records from two databases to compare 75,996 adults taking metformin for their type 2 diabetes to 13,336 records from patients who were not taking metformin but were using other types of diabetes medicine. They analyzed data from 51,385 adults from the N3C data set and 37,947 adults from the PCORnet data set.
Outcomes were long COVID diagnosis or death within 6 months of a confirmed COVID-19 infection, because death precludes a diagnosis of PASC, the authors explained.
Overall, PASC diagnoses were seen in 1.7% of patients in the N3C of the data set and 1.3% in the PCORnet set.
(Excerpt) Read more at cidrap.umn.edu ...
what’s your A1c ?
Last blood test was 5.5
So am I. Combine that with the Ivermectin and HCQ prescribed when I had Covid two years ago, and I’m good to go. My weekly bowl of Caldo de Pollo has kept me healthy this year. Perhaps I should write a book…lol.
Excellent!
Have you considered reducing to 500mg?
saw article yesterday it helped some animal stay young. I think Monkeys.
I would have to ask the Dr. What is your A1C?
Metformin has been touted by some as a way to greater longevity, and the Chinese have just announced a study showing that it can slow down the brain’s aging process:
Thanks for sharing
From the Discussion section...
...At the molecular level, Met shows anti-aging effects by reducing ATP levels through the activation of AMPK64. These data suggest that Met may contribute to improving both healthy lifespans and age-related diseases...
pill-pushing cartel members get a commission with each prescription they write.
5.7
Excellent
I’ve taken 2000 mg Metformin for years, but Dr. cut me back 1000 mg last week to avoid BG highs in the middle of the night.
Are you doing better?
Highs SB Lows..
It’s only been a couple days, but haven’t been alerted by my Dexcom in the middle of the night.
Back to origanal article, I haven’t been able to smell or taste for over 3 years...
In the General/Chat forum, on a thread titled Common diabetes drug linked to lower rate of long COVID, mewzilla wrote: From a paper published last month, get a load of this... Looks like the NIH is circling the wagons. The NIH contributed to the research in 4 different capacities.
At your link - here's the disclosure for potential conflict of interest (mostly pharmas)
Potential conflicts of interest. J. B. B. reports contracted fees and travel support for contracted activities for consulting work paid to the University of North Carolina by Novo Nordisk; grant support by NIH, PCORI, Bayer, Boehringer-Ingelheim, Carmot, Corcept, Dexcom, Eli Lilly, Insulet, MannKind, Novo Nordisk, and vTv Therapeutics; personal compensation for consultation from Alkahest, Altimmune, Anji, Aqua Medical Inc, AstraZeneca, Boehringer-Ingelheim, CeQur, Corcept Therapeutics, Eli Lilly, embecta, GentiBio, Glyscend, Insulet, Mellitus Health, Metsera, Moderna, Novo Nordisk, Pendulum Therapeutics, Praetego, Stability Health, Tandem, Terns Inc, and Vertex.; personal compensation for expert testimony from Medtronic MiniMed; participation on advisory boards for Altimmune, AstraZeneca, and Insulet; a leadership role for the Association of Clinical and Translational Science; and stock/options in Glyscend, Mellitus Health, Pendulum Therapeutics, Praetego, and Stability Health. M. A. P. receives consulting fees from Opticyte and Cytovale. A. B. K. has served as an external consultant for Roche Diagnostics; received speaker honoraria from Siemens Healthcare Diagnostics, the American Kidney Fund, the National Kidney Foundation, the American Society of Nephrology, and Yale University Department of Laboratory Medicine; research support unrelated to this work from Siemens Healthcare Diagnostics, Kyowa Kirin Pharmaceutical Development, the Juvenile Diabetes Research Foundation, and the NIH; support for travel from College of American Pathologists Point-Of-Care Testing Committee; participation on an advisory board for the Minnesota Newborn Screening Advisory Committee; grants from NIH and JDRF for multiple unrelated clinical research projects and Kyowa Kirin Pharmaceutical Development and Siemens Healthcare Diagnostics for unrelated clinical research studies; and leadership roles for the American Board of Clinical Chemistry, Association for Diagnostics and Laboratory Medicine (ADLM) Evidence-Based Laboratory Medicine Subcommittee, and ADLM Academy Test Utilization Committee. M. R. R. reports consulting fees from 20/20 Gene Systems for coronavirus disease 2019 testing. D. B. R. reports grants from the NIH NCATS ACTIV-6 Steering Committee Chair. K. C. reports stock or stock options for United Health Group. C. T. B. reports consulting fees from NCATS/DCRI and the ACTIV-6 Executive Committee and support for travel from Academic Medical Education. All other authors report no potential conflicts.
All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclo
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