Study finds regular aspirin use associated with greatest reduction in colorectal cancer among those most at risk

Medical Xpress / Mass General Brigham / JAMA Oncology ^ | Aug. 1, 2024 | Andrew Chan, MD, MPH et al

[ConservativeMind]

Regular aspirin may help lower risk of colorectal cancer in people with greater lifestyle-related risk factors for the disease, according to a study.

For the study, researchers analyzed the health data from 107,655 participants from the Nurses' Health Study and Health Professionals Follow-Up Study. They compared the colorectal cancer rates in those who took aspirin regularly with those who did not take aspirin regularly. Regular aspirin use was defined as either two or more standard dose (325 mg) tablets per week or daily low-dose (81 mg) aspirin.

Study participants were followed starting from an average age of 49.4 years. Those who regularly took aspirin had a colorectal cancer 10-year cumulative incidence of 1.98%, compared to 2.95% among those who did not take aspirin.

The benefit of aspirin was largest among those with the unhealthiest lifestyles. Those with the lowest healthy lifestyle scores (unhealthiest) had a 3.4% chance of getting colorectal cancer if they did not take regular aspirin and a 2.12% chance of getting colorectal cancer if they took aspirin regularly.

By contrast, in those with the highest healthy lifestyle scores (healthiest), the colorectal cancer rates were 1.5% in regular aspirin-taking group and 1.6% in the non-regular aspirin group. This means that in the least healthy group, treating 78 patients with aspirin would prevent one case of colorectal cancer over a 10-year period, while it would take treating 909 patients to prevent one case for the healthiest group.

Lifestyle scores were calculated based on body mass index, frequency of cigarette and alcohol use, physical activity, and adherence to a high-quality diet.

While the study included those who took regular standard-dose (325 mg) aspirin two times a week in the regular-aspirin using category, Sikavi noted that "based on prior studies, the best evidence supports daily low-dose (81 mg) aspirin for prevention."

[ConservativeMind]

For people who have a poor “lifestyle score,” aspirin helped most.

“Lifestyle scores were calculated based on body mass index, frequency of cigarette and alcohol use, physical activity, and adherence to a high-quality diet.”

For these people, the risk of cancer over ten years went from 3.4% to 2.12%, by taking aspirin.

They ended by saying low dose daily was probably better than twice a week with a normal aspirin.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[rdl6989]

It seems they’re always finding new used for aspirin.

[rdl6989]

Uses not used.

[SaveFerris]

I take (or try to take) at least one aspirin per day - 325mg

It’s my go-to medicine ... LOL

Now I DID eat McDonald’s the day before and yesterday along with Taco Bell last night (but not the burrito, so.....)

Had the 2nd Quarter Pounder with Cheese today.....

Burp (again)

[nickcarraway]

Why does it matter if it was the burrito or not? Don’t they mostly have the same ingredients?

[Chode]

now they tell me...

[SaveFerris]

Well the double layer taco 🌮 Shirley is healthy

But the burrito 🌯..... 😜

[Georgia Girl 2]

😮

[SaveFerris]

(Don’t they mostly have the same ingredients?)

Meat, cheese, vegetables.....

It’s an old comic routine

[Mozzafiato]

Why does it matter if it was the burrito or not? Don’t they mostly have the same ingredients?

Mexican food is all the same slop just packaged differently (tacos, burritos, enchiladas, etc), lol.

[SaveFerris]

😄😃🤣😂

[Antioch]

The reduction in cancer incidence isn’t because people have aspirin deficiencies it’s because people in poor health have microbiomes in a state of general inflammation and aspirin tends to reduce that. The proper way to reduce colorectal cancer is to promote a healthy gut flora, through reductions in pro-inflammatory lipid intake, and an increase in fermented foods, probiotics, vitamin D and C.

[DannyTN]

It’s all that fresh blood from the aspirin induced bleeding that cures the cancer.
/rimshot

I have no real opinion on the risks/benefits of aspirin.

[Governor Dinwiddie]

#14: "It's all that fresh blood from the aspirin induced bleeding that cures the cancer."

Believe it or not, you are on the right track.

Aspirin causes tumors to bleed which leads to spotting and blood in your stool and on toilet paper. It leads to earlier diagnosis because most folks are alarmed by this abnormal occurrence.

[logi_cal869]

Yet another appalling waste of study $$ by NIH.

[kawhill]

Two 81mg baby aspirin per day for this cowboy.

[Carriage Hill]

Have you seen this one?

“New Drug Restores Lost Alzheimer’s Memories in Mice”...

https://www.yahoo.com/news/drug-restores-lost-alzheimer-memories-143056932.html

[ConservativeMind]

There does not appear to be any idea of when it will be available, but it sounds hopeful.