Posted on 08/05/2024 4:52:27 PM PDT by ConservativeMind
Researchers have discovered that a diet free of the amino acid tryptophan can effectively halt the growth of liver cancer in mice. Their findings offer new insights for dietary-based cancer treatments and highlight the critical role of the tryptophan metabolite indole 3-pyruvate (I3P) in liver tumor development.
Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related mortality worldwide, with limited options for effective treatment and a five-year survival rate of about 30%. The study shows that growth of liver cancers driven by the MYC oncogene is particularly dependent on tryptophan, which is converted into I3P as well as other metabolites.
By removing tryptophan from the diet of mice, researchers stopped the growth of MYC-driven liver tumors and restored normal gene expression in liver cells. Notably, this dietary intervention did not affect protein synthesis in normal cells, suggesting a targeted therapeutic approach that spares healthy tissues.
"Liver tumors require large amounts of tryptophan to generate the oncometabolite I3P," Dr. Conacci-Sorrell said. "A tryptophan-free diet prevents liver tumor growth by a mechanism that depends on I3P but is independent of translation, the process by which proteins are synthesized from amino acid building blocks. Because tryptophan is the amino acid with the lowest abundance in the proteome, short-term dietary manipulation is safe for healthy tissues but not for cancer cells."
Among foods high in tryptophan are turkey, red meat, pork, chicken, tofu, milk, soybeans (including edamame), quinoa, oats, and fish.
The research highlights the complex role of tryptophan metabolism in cancer. While tryptophan is known to be metabolized into several important compounds, including the neurotransmitter serotonin and kynurenine, a precursor of the B vitamin niacin, the study showed MYC-driven liver tumors preferentially utilize tryptophan to produce I3P rather than kynurenine. This shift underscores the potential for targeting specific metabolic pathways in cancer treatment.
(Excerpt) Read more at medicalxpress.com ...
It can be hard to eat without getting tryptophan, but some foods are low or devoid of it, including collagens.
A short list of foods that contain tryptophan:
Chicken, eggs, cheese, fish, peanuts, milk, turkey, tofu and soy. Good luck avoiding it!
Oh, sure! Take away my joy!
You can have my turkey, when you pry it from my cold, dead hands.
I use whiskey to keep my liver in check...
Sounds like a starvation diet to me. I don’t know that much would be left to sustain life.
ethanol is a fine non-polar solvent which should be a good diluting supernatant to tryptophan
(not a doctor, not a chemist, not a lawyer, didn’t even stay in a Holiday Inn express in probably at least a year)
Isn’t the ‘traditional’ japanese diet (known for longevity) high in soy and fish?
Turkey çomas.
Yes, the liver is a muscle which needs exercise.
But, insects and plant protein have no tryptophan, so you can eat them.
As the great Doctor Leonard ‘Bones’ McCoy stated in The Omega Glory, long life is primarily genetic. Lazarus Long would heartily agree.
Or you could not take the vax and see that none of those meats and poultry even cause liver cancer when consumed in a healthy way.
This is true. The Japanese are always reminding us of their ‘superior’ diet. I joke about it, but I listen to them.
You can have my turkey leg when you pry it from my slightly greasy, cranberry stained hands...
Eat ze bugs!
I’m betting it’s the soybeans that are the worst, but I don’t know. Liver cancer incidence and mortality rates are approximately 1·5 to 2 times higher in American Indian or Alaska Native (AIAN), Asian, Black, and Latino populations than in the White population in the USA. (The Lancet) Asians eat a lot of soybean products, and Alaska natives traditionally eat mostly meat.
10 Best Foods to Eat for a Collagen Boost
1. Beef Bone Broth
2. Skin-On Chicken
3. Pork Bone Broth
4. Sardines
5. Organ Meats
6. Collagen-Infused Drinks
7. Gummy Candy
8. Berries
Pick your favorite—blueberries, raspberries, strawberries or blackberries. They’re all a great way to add vitamin C to your diet, a nutrient that helps your body build collagen.
9. Broccoli
Another tasty, easy way to add vitamin C to your diet is broccoli.
10. Aloe Vera
https://www.eatingwell.com/article/7896640/best-foods-to-eat-for-a-collagen-boost/
Just take your sleeping pills and love ut.
How about bugs?
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