Diabetes-reversing drug boosts insulin-producing cells by 700%

https://newatlas.com/ ^ | July 14, 2024 | Michael Irving

[Jonty30]

Along with lifestyle changes, diabetes is now potentially cured.

[DannyTN]

DYRK1A inhibitors for disease therapy: Current status and perspectives

Looks like EGCG from Green Tea is one. Others are listed.

Desmethylbellidifolin (DMB) is a natural xanthone extracted from Gentianella acuta

Gentian supplements are available.

[conserv8]

bkmk

[Jonty30]

I think it’s a really good idea to try and source these nutrients from real foods, instead of a vial or pill.

[Chad C. Mulligan]

Diabetes is never cured, only delayed. Been diabetic for over 25 years now.....I know. Drugs to rev up my pancreas eventually “burned it out” as my doctor put it. But they are mega-profitable for big pharma, so they keep coming.

It was a happy day in my life when my doctor put me on insulin, letting me stop taking those drugs. Especially metformin, which always left me feeling like I’d ingested an industrial floor cleaner.

[Jonty30]

It’s all pieces of the puzzle. With each step that can be taken, diabetes becomes potentially more curable, or delayable to your point.

That’s why I said that along with dietary changes. You can’t fix this with drugs alone, but the drugs might provide a boost that, along with the requisite dietary and life style changes, you may be able to reverse course.

[jimfr]

Does a diabetic need to increase their insulin production by 700%? Low blood sugar is just as much a problem as high blood sugar.

[Jonty30]

I think the figure they cite is what can be done. I doubt that is what they would do for everybody.

Ideally, you want to do everything through lifestyle changes and discipline, but that will not be enough for some. For some, they will need a drug to overcome the hump that they can’t get over through lifestyle change alone.

In the end, it’s all about lasting as long as possible with minimal harm to yourself.

[Adder]

Sounds promising for type 1 but not so much for type 2.

type 2 is not from a lack of insulin. Producing more without fully knowing how much more can be dangerous as heck, it seems to me.

[Chad C. Mulligan]

Delay. Once the β-cells in the Islets of Langerhans are dead, there’s no bringing them back, short perhaps of transplantation or some development from stem cells. And even that won’t correct whatever it is in our metabolism that interferes with insulin to begin with. I’ve read several hypotheses, but I don’t think anybody really knows.

[Jonty30]

Delaying it is pretty good.

[Chad C. Mulligan]

Producing more without fully knowing how much more can be dangerous as heck, it seems to me.

It is. The natural regulating mechanism is also compromised, which is why we are all sticking our fingers several times a day to get a blood sample to measure. Which is painful, as well as expensive. Overdo the drugs or the insulin and you've got a risky situation, (you can faint, even die), which is why we all have some sort of sugar shot handy to pick us up if we get excessively low blood glucose. Being diabetic is a daily chore, no mistake.

[Chad C. Mulligan]

More to your post - yes, this may be a cure for Type ones, but not Type Twos. As I understand it, Type Twos are secreting an unnecessary molecule that binds to the “key” that insulin uses to enter our cells. As far as I know nobody is sure where it comes from or how to stop it. All of the therapies I know about simply flood the bloodstream with enough insulin to overwhelm the blocking molecule. Open to new knowledge though, even at my advanced age.

[Robert DeLong]

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

Source: Article liked to by post

What are the risks of taking Ozempic for weight loss? <> The Food and Drug Administration (FDA) approved Wegovy, a brand name for semaglutide, for weight loss in adults who have high cholesterol, type 2 diabetes, or high blood pressure.

Although some people may benefit from taking Ozempic for weight loss if they have a comorbid medical issue, using this prescription medication for the sole purpose of losing weight medicalizes fatness and fails to address the real issue: weight stigma. The so-called “obesity epidemic” harms people living in larger bodies, contributes to anti-fatness and body weight bias, and can lead to mental health problems and eating disorders, such as binge eating disorder, anorexia nervosa, or bulimia nervosa.

Some people with eating disorders or patterns of disordered eating may misuse semaglutide (and other weight loss medications) for weight management since this medication can reduce appetite and caloric intake.2 However, this can be risky, especially for those with anorexia nervosa who may already significantly restrict their food intake—it could increase the likelihood of undernutrition and its many dangerous consequences, such as:5

Reduced muscle functioning
Electrolyte disturbances
Reduced kidney functioning
Chronic gastrointestinal issues
Colon malfunctioning
Increased risk of infection
Depression and anxiety

Source

[bert]

As an “old” Type 2 patient who was diagnosed 12 or 14 years ago, My testimony is that Type 2 is a disease of numbers.

My diagnosis was made on the basis of lab reports 6 months apart where the blood sugar level exceeded 140 twice in a row. While investigating the diagnosis, I learned that very recently prior to my diagnosis, the level was increased from 126 to 14 a difference of 14 points. The consensus on the threshold number changed

I had no symptoms then nor now other than elevated blood sugar and a high A1c number. Afain not too long ago the A1c threshold was upped to 7.0 for persons my age. The consensus on the threshold number changed.

From the beginning to the present, over the say 12 year period, my weight dropped from 230 to the present 175. I don’t know why. I did not diet or substantially increase exercise.

However, I’m convinced that a body mass index of <130 or 129 directly correlates to a lowered A1c. I have never seriously controlled nor purposely over time decreased carbohydrate or sugar intake. I did resume eating forbidden cholesterol foods like bacon and butter and eggs

Again........ aside from lab report numbers, I have absolutely no symptoms of diabetes Type II

[Jonty30]

I always say to take it for 5lb lots and then quit for a few months to let the body catch up and make the requisite lifestyle changes so you don’t have to rely on it.

[Robert DeLong]

Well, that is sound advice, but as all too often is the case, people tend to be their own worst enemy.

[ptsal]

bkmk

[Flag_This]

"The natural regulating mechanism is also compromised, which is why we are all sticking our fingers several times a day to get a blood sample to measure."

My son has type 1 diabetes and a glucose monitoring system was a complete game-changer for helping him manage his blood sugar. You should take a look at them, if you haven't already.

[NetAddicted]

I haven’t read article yet. Does drug work for Type 1 or Type 2?