Posted on 05/24/2024 2:10:07 PM PDT by Chickensoup
How Does One Find Private Genetic Testing.
I am looking for private genetic testing and if needed counseling related to family history of dementia.
How does one find this sort of thing.. not interested in getting primary involved.
I am looking for private genetic testing and if needed counseling related to family history of dementia.
How does one find this sort of thing.. not interested in getting primary involved.
Be careful, You might discover some skeletons in the closet.
My family did.
Recent massive AI studies have shown how hearing impairment can cause Dementia or lead to it.
Using AI to review medical problems of many patients:
AI Overview: Yes, dual sensory impairment (DSI) of hearing and vision is strong!
…
Yes, dual sensory impairment (DSI) of hearing and vision is strongly associated with an increased risk of dementia in older adults. In fact, people with DSI are nearly twice as likely to develop dementia as those without impairments. For example, a 2022 cohort study of over 500,000 people in the UK found that participants with DSI had an 82% higher risk of dementia, compared to 50% for those with vision impairment alone and 42% for those with hearing impairment alone.
MedicalNewsToday
Hearing plus vision loss increases the odds of dementia
Jul 20, 2020 — People with both hearing and visual loss were nearly twice as likely to develop dementia as those without such impairments. However, according to the results, the increased risk of dementia for an individual with DSI is only somewhat related to the severity of hearing and visual impairment. While those classified as having a high level of DSI are at the greatest risk of developing dementia, those with lower DSI levels also have a significantly higher risk of dementia.
AAIC
Longitudinal Changes in Hearing and Visual Impairments and ...
May 5, 2022 — Question Is dual sensory impairment associated with risk of dementia, including Alzheimer disease and vascular dementia, among older adults? Findings In this cohort study that included 2927 adults aged 65 years and older, dual sensory impairment was associated with a 160% increased risk for all-cause dementia and a 267% increased risk for Alzheimer disease. Meaning These findings suggest that assessment of both hearing and vision may help to identify older adults who are at high risk of developing dementia.
Healthy Hearing:
Hearing and vision loss equals ‘substantial’ risk for dementia ...
Jul 11, 2022 — Similarly, a June 2022 cohort study in Frontiers in Aging Neuroscience, which looked at more than half a million people in the UK also found that participants with vision impairment had a 50 percent higher risk for developing dementia, while people with a hearing impairment had a 42 percent higher risk. Highest still was the risk for developing dementia in people with dual sensory impairment: 82 percent.
The increased risk of dementia for people with DSI is somewhat related to the severity of their impairments, but those with lower levels of DSI also have a significantly higher risk. Assessing both hearing and vision may help identify older adults who are at high risk of developing dementia.
Hearing loss can also be an early symptom of dementia. Central hearing loss, which is when the brain has trouble processing sounds, may be a very early symptom of Alzheimer’s disease. To: Reduce the risk of dementia: you can: Get your hearing tested, Protect your hearing from a young age, and Use hearing aids.
Consider what kind of anonymity you have in mind. From employers? From family? Or from insurers and medical providers?
“Be careful, You might discover some skeletons in the closet.”
We have few friends, end up with some big surprises and issues.
Many if not most have had positive responses when dealing a a “new/unknown” relative.
Probably there is no such thing as “private” genetic testing...
There is, probably. a “publishers clearing house” of genetic testing...
Money to be made with personal data...
Don’t do it. Pray and live healthy.
“Be careful, You might discover some skeletons in the closet.”
Or the woodpile.
Be sure the lab does not send the sample to China. That’s where most DNA testing is done, and stored in a PLA data base.
Your best bet against dementia is being healthy and exercising. Nothing you can do other than that.
Knowing you have dementia-ridden relatives will only depress you.
Nebula.org
they may have a sale for memorial day
I bought the lifetime subscription but you can buy it for less. They do have consultants you can talk to but I have never had to do it.
You can do it with a prepaid card and fake name but you will have to have an address they can send the kit to.
It is a whole genome test. It has helped me figure out many things. I uploaded the data to genetic genie and found things Doctors hadnt even bothered to look for in terms of genetic problems with certain drugs.
This is not a one stop deal. For example, if you look at a study and it says R123456 G/G is a problem you have to jump through hoops to figure it out because they go by chromosome location. But it does have a searchable menu that you can put in a disease and it will pop up some known studies for your variants.
If you have the name of a gene you can also look it up that way.
There is way more information provided than you will know what to do with.
So far my tests have been accurate with Nebula. I find the problem. I go into the Dr. They do the official $4 grand genetic check and it turns out it was correct.
The problem with Dr genetic testing is that in my experience they dont check as many variants for the gene. It was explained to me that they check the well established and ones they can do something about.
Whereas Nebula is giving you all the variants they find and you will get many that are of uncertain significance.
Looks like they dont offer lifetime subscription anymore. Right now it is yearly or 3 years.
Scientific American had an article about research findings from over twenty years ago that proved stress makes the blood brain barrier permeable.
Another researcher that was the protege of the Australian that discovered bacteria causes stomach ulcers found bacteria in Alzheimer’s plaques.
Before you go head to head with the genetic windmill read the book, “Not In Our Genes”.
If I were you I would focus on the gut biome with emphasis on Akkermansia muciniphila and the correlations between the lack thereof and medical issues.
IOW, you may learn more relevant information from having your stool tested for the bacterial content than a genetic test.
That guy doesn’t go into enough detail on Nebula. The reports are not the real value to me.
This is the important browser: Gene.iobio for Nebula Genomics
So here is how I used it. My bloods tests were indicating a certain genetic problem. I was 100% sure of it but I couldnt get anyone to test for it because nobody heard of it.
It was causing problems because I would be told the test was normal when in fact it was red flagging an issue.
It is not one generally ordered. I was so fed up I got this genetic test and sure enough..when you look it up with the browser there it is telling you exactly why my blood test is so screwed up. A “normal” value is actually highly elevated but no one would believe me until I printed this out and said SEE...this is what I was talking about. My genetic curse means my normal value is much much lower and a “normal” value means you better damn well be understanding I have a problem that is going on.
btw, 23andme test was not good enough to pick up the issue and many others that I have but I do use them as a reference point
It is easier to look up RS123456 in their database and figure out the chromosome location.
The P glycoprotein gene is the gatekeeper for the blood brain barrier
If you have a problem with that gene then you may have additional problems.
If you have a problem with genes that clear toxins in the brain you may be more at risk.
I have both those genetic problems.
I have had a brain MRI and waiting for the doctor visit to tell me how much of a mess it is with white matter, etc. I have read the report. Now I need the expert.
What good does that report do. Really not much. They cant do much other than tell you to work on risk factors for stroke etc. tell me to take statins which I dont want to do. I have to figure out another way.
Also I had no idea that reflux can increase risk of stroke.
That’s strange. I had a great aunt who died at age 104 and was both deaf and blind! She was clear as a bell until last two yrs.
You’re probably looking for a whole genome microarray analysis to look for point mutations, duplications and deletions.
It’s not the same as sequencing but is recommended for developmental delays, autism, early onset dementia and the like.
Sometimes it reveals the source of the problem and at times that can be addressed with medicines.
I’m not a geneticist but went through this with a family member so I studied a lot about this.
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