Posted on 02/06/2024 8:47:58 PM PST by SeekAndFind
“A major challenge now is how to efficiently de-risk potential toxicities associated with mRNA technology,” the scientists wrote in the paper, which was published by Nature Reviews Drug Discovery on Jan. 23.
The Moderna and Pfizer COVID-19 shots use modified messenger ribonucleic acid (mRNA) technology. The mRNA is delivered by lipid nanoparticles (LNP).
The toxicity risks include “lipid nanoparticle structural components, production methods, route of administration and proteins produced from complexed mRNAs,” the authors of the paper said.
Authors of the paper include Eric Jacquinet and Dimitrios Bitounis, Moderna employees, and Maximillian Rogers, who was working at Moderna when the paper was being done.
Moderna didn’t respond to a request for comment.
The mRNA vaccines have multiple known side effects, including heart inflammation and severe allergic shock. Those may stem from hypersensitivity reactions, which can be elicited by “any LNP-mRNA component” but are most likely triggered by PEGlyated lipid nanoparticles, which is “the most potentially reactogenic component,” the scientists said.
Polyethylene glycol, or PEG, an ingredient in the Pfizer and Moderna COVID-19 vaccines, is known to cause allergic reactions. Outside scientists are divided over the mechanism behind the heart inflammation, while Pfizer has posited that the LNPs are behind the issue.
The new paper drew from prior publications and other data. The authors didn’t carry out any new experiments.
Some of the papers cited included those that have found mRNA and the spike protein delivered by Moderna’s shot in various parts of human beings weeks or months after vaccination, despite health officials claiming when the vaccines were rolled out that such materials would exit the body within days.
The scientists said that Moderna’s COVID-19 vaccine is “safe and effective” and hailed the development of an updated shot as “demonstrat[ing] the rapid timeline for modifications with mRNA technology in the clinic.” Due to the “transient nature of mRNA,” though, “repeat administration may be necessary,” they said.
The scientists added later that reducing risks of toxicities with mRNA-based vaccines and drugs is necessary but “complicated.” That can be accomplished through a multi-pronged approach that includes advanced testing in laboratories and adjusts preclinical, animal trials to better account for “differences in human and animal physiology.”
Moderna and other companies are currently testing a number of new mRNA products, including influenza vaccines and cancer treatments.
“Thanks to the mRNA platform we built, we have an exciting pipeline, with up to 15 launches in the next five years,” Stephane Bancel, Moderna’s CEO, told investors in the company’s most recent earnings call.
The paper’s corresponding author, Mansoor Amiji of Northeastern University’s Departments of Pharmaceutical Sciences and Chemical Engineering, referred a request for comment to Mr. Bitounis, who didn’t provide any answers.
Dr. Robert Malone, who helped invent the mRNA technology, said the paper downplayed the range of risks that have been linked to the mRNA-based vaccines and may be part of a limited hangout, or a propaganda technique.
That technique, a form of misdirection, involves people offering some information to obscure or prevent the discovery of other information.
“My most generous interpretation of the overall intent of the article is that this article summarizes and represents information concerning risks and toxicities of this platform technology which Moderna wishes to have disclosed in a manner which puts the firm, its activities and the underlying platform technology in the best possible light,” Dr. Malone, who wasn’t involved with the paper, wrote in his review.
“A less generous interpretation of intent is that this article represents a subtle form of propaganda strategy commonly referred to as a limited hangout.”
.
Deep States, plural, all knew.
They just didn't give a damn.
I agree💯%
Sod off, troll.
You should have been banned years ago.
I seem to recall a story early on (like 2yrs ago) during this entire fluster cuck that the LNPs in particular were made by a CHINESE pharmaceutical company. There was some question back then that “there were quality issues with these LNPs.”
If I recall, the researcher was concerned with how easily the LNPs migrated and entered various cells and if they contained contaminants, real damage could be done.
It’s looking like EVRYTHING associated with China is crap.
Then again, I may be totally wrong on what I just recalled.
And they still keep pushing these poisons in TV ads....
https://www.bristows.com/news/spotlight-on-mrna-ip-landscape/
From the article:
Early work on LNPs was carried out by Canadian biotech Arbutus Biopharma Corporation in collaboration with the University of British Columbia[8]. Several companies have since taken licences of LNP patents owned by Arbutus. In 2018, Arbutus spun out rights to its LNP technology (excluding rights to hepatitis B) into a company called Genevant Sciences GmBH as part of a joint venture with Roivant Sciences Ltd[9]. The Arbutus patents have also been the subject of some litigation (see below).
I believe that you are the only Branch Covidian still left on this site. The rest of them have probably returned to their jobs of spreading propaganda for the government in other areas.
(From the article):"The Moderna and Pfizer COVID-19 shots use modified messenger ribonucleic acid (mRNA) technology.
The mRNA is delivered by lipid nanoparticles (LNP).
The toxicity risks include “lipid nanoparticle structural components , production methods, route of administration and proteins produced from complexed mRNAs,” the authors of the paper said."
"Authors of the paper include Eric Jacquinet and Dimitrios Bitounis, Moderna employees, and Maximillian Rogers,
who was working at Moderna when the paper was being done."
"Moderna didn’t respond to a request for comment."
The mRNA vaccines have multiple known side effects, including heart inflammation and severe allergic shock. Those may stem from hypersensitivity reactions, which can be elicited by “any LNP-mRNA component” but are most likely triggered by PEGlyated lipid nanoparticles, which is “the most potentially reactogenic component,” the scientists said.
"Polyethylene glycol, or PEG, an ingredient in the Pfizer and Moderna COVID-19 vaccines, is known to cause allergic reactions.
Outside scientists are divided over the mechanism behind the heart inflammation, while Pfizer has posited that the LNPs are behind the issue."
"The new paper drew from prior publications and other data. The authors didn’t carry out any new experiments."
"The scientists said that Moderna’s COVID-19 vaccine is “safe and effective” and hailed the development of an updated shot as “demonstrat[ing] the rapid timeline for modifications with mRNA technology in the clinic.”
Due to the “transient nature of mRNA,” though, “repeat administration may be necessary,” they said."
"The scientists added later that reducing risks of toxicities with mRNA-based vaccines and drugs is necessary but “complicated.” That can be accomplished through a multi-pronged approach that includes advanced testing in laboratories and adjusts preclinical, animal trials to better account for “differences in human and animal physiology.”
"Moderna and other companies are currently testing a number of new mRNA products, including influenza vaccines and cancer treatments."
H/T to SeekAndFind !
Not buying it...
Lenny Kravitz
As noted by the scientists of Epoch Times, Rober Malone was concerned enough to publish his opinion of this NRDD paper at PubMed.
https://rwmalonemd.substack.com/p/review-and-commentary-strategies
Oh. Wait. This is his substack account, not PubMed.
Funny, because Malone has the ability to publish in scientific journals but instead chose substack instead of where his peers would see it and critique what he is saying. Go figure
You’d almost think that this was aimed at his lay public fan club rather than his fellow scientists.
Shocked you are still allowed to be on FR given that you support the Biden/Dem/RINO/Fauci narrative on possibly the most damaging scam in the history of the Republic. The Federal Reserve was bad enough, but it did not kill millions in a short period of time.
Oh, just stop.
You don’t get a say on who is allowed on FR. Instead of stomping your feet about that, debate the issue.
Knick off the groupthink.
In the past, I think some were removed for speaking out against the war in Iraq, despite the conservative antiwar position having a long history in America. That’s OK, because the forum is privately owned and we all respect the authority of the owners. The support for mandates (public or private) is a far-left ideological position and has no place on our side. That said, I’m not advocating for anyone to be removed, but I don’t think the mods would accept advocacy for gun control or same-sex “marriage” here.
She has spike brain. We cannot expect anyone with that condition to deviate from the narrative.
Re: 36 - Agreed. There are core issues such as marriage, Bill of Rights such as 2nd Amendment, etc.
Thanks for the explanation.
So the third time IS the charm!?
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.