Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Berberine ameliorates diabetic cardiomyopathy in mice by decreasing cardiomyocyte apoptosis, oxidative stress: Study
Medical Xpress / Compuscript Ltd / Cardiovascular Innovations and Applications ^ | Nov. 7, 2023 | Xiaoqiang Sun et al

Posted on 11/14/2023 10:27:39 PM PST by ConservativeMind

Diabetic cardiomyopathy is a multifaceted complication of diabetes that lacks effective treatments. Berberine (BBR), a bioactive compound from Rhizoma coptidis, has potential therapeutic implications, but its precise role in diabetic cardiomyopathy has yet to be defined.

In a new study, a diabetic cardiomyopathy model was established by administration of a high-fat diet and streptozotocin injection to C57BL/6J mice. Concurrently, the mice received BBR treatment daily for a duration of eight weeks. After the treatment period, myocardial injury, cardiac function, and the levels of oxidative stress and apoptosis were assessed.

BBR significantly ameliorated cardiac dysfunction and histopathological damage caused by diabetic cardiomyopathy. This treatment also elevated serum superoxide dismutase levels while decreasing malondialdehyde levels. The anti-apoptotic activity of BBR was evidenced by a decrease in TUNEL-positive cells and the percentage of apoptotic cells, as determined by flow cytometry, in conjunction with diminished levels of BCL2-associated X protein/B cell lymphoma 2 (BAX/BCL2) in heart tissues.

Mechanistically, BBR was found to ameliorate diabetic cardiomyopathy by upregulating the expression of myocardial methionine sulfoxide reductase A (MsrA) and concurrently suppressing cardiac CaMKII oxidation.

BBR alleviates diabetic cardiomyopathy by inhibiting myocardial apoptosis and oxidative stress.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: berberine
Berberine increased superoxide dismutase (SOD), a key body antioxidant we make less of, as we age. I previously posted how taurine can augment natural processes to increase SOD.

The result is heart muscle cells are much less likely to die, with this help. Our heart muscle cells are generally believed to never be replaced, so limiting damage is thought to be the best we can do, today.

1 posted on 11/14/2023 10:27:39 PM PST by ConservativeMind
[ Post Reply | Private Reply | View Replies]

To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 11/14/2023 10:28:16 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Wonderful


3 posted on 11/14/2023 10:32:13 PM PST by Ken Regis (I concur. )
[ Post Reply | Private Reply | To 2 | View Replies]

To: Ken Regis

Great news for mice.


4 posted on 11/14/2023 10:34:46 PM PST by dfwgator (Endut! Hoch Hech!)
[ Post Reply | Private Reply | To 3 | View Replies]

To: ConservativeMind

I’m sorry I don’t have my smart ass doctor talk translator with me


5 posted on 11/14/2023 10:58:06 PM PST by NWFree (Sigma male 🤪)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

6 posted on 11/14/2023 11:30:48 PM PST by mikey_hates_everything
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

.


7 posted on 11/15/2023 1:39:43 AM PST by sauropod (The obedient always think of themselves as virtuous rather than cowardly.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: mikey_hates_everything

Your post is priceless

Nathan Thurm is a big fav of mine to this day.😆😆😆😆

Famous words: “ I know that” 😂😂😂


8 posted on 11/15/2023 3:51:41 AM PST by thesligoduffyflynns (WHEN 💎GOING THROUGH KEEP GOING💎 IF IT DOESNT KiILL YOU IT will MAKE YOU STRONGER💎)
[ Post Reply | Private Reply | To 6 | View Replies]

To: ConservativeMind
Berberine ameliorates diabetic cardiomyopathy in mice by decreasing cardiomyocyte apoptosis, oxidative stress

I can't tell you how many bar bets I've won because I knew that.

9 posted on 11/15/2023 4:10:05 AM PST by GreenHornet
[ Post Reply | Private Reply | To 1 | View Replies]

To: NWFree

Berberine is a chemical found in some plants like European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric.

Berberine is a bitter-tasting and yellow-colored chemical. It might help strengthen the heartbeat, which could benefit people with certain heart conditions. It might also kill bacteria, help regulate how the body uses sugar in the blood, and help reduce swelling.

https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine


10 posted on 11/15/2023 4:38:56 AM PST by Uncle Miltie (islam is a totalitarian death cult founded by a child rapist.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: Uncle Miltie

Thanks


11 posted on 11/15/2023 6:33:18 AM PST by NWFree (Sigma male 🤪)
[ Post Reply | Private Reply | To 10 | View Replies]

To: thesligoduffyflynns

Nathan Thurm and Ed Grimley are two of my favorites. Short is a genius.


12 posted on 11/15/2023 6:51:01 AM PST by mikey_hates_everything
[ Post Reply | Private Reply | To 8 | View Replies]

To: mikey_hates_everything

I muuuust say ....
😂🤣😂


13 posted on 11/25/2023 9:29:47 AM PST by thesligoduffyflynns (WHEN 💎GOING THROUGH KEEP GOING💎 IF IT DOESNT KiILL YOU IT will MAKE YOU STRONGER💎)
[ Post Reply | Private Reply | To 12 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson