Berberine ameliorates diabetic cardiomyopathy in mice by decreasing cardiomyocyte apoptosis, oxidative stress: Study

Medical Xpress / Compuscript Ltd / Cardiovascular Innovations and Applications ^ | Nov. 7, 2023 | Xiaoqiang Sun et al

[ConservativeMind]

Diabetic cardiomyopathy is a multifaceted complication of diabetes that lacks effective treatments. Berberine (BBR), a bioactive compound from Rhizoma coptidis, has potential therapeutic implications, but its precise role in diabetic cardiomyopathy has yet to be defined.

In a new study, a diabetic cardiomyopathy model was established by administration of a high-fat diet and streptozotocin injection to C57BL/6J mice. Concurrently, the mice received BBR treatment daily for a duration of eight weeks. After the treatment period, myocardial injury, cardiac function, and the levels of oxidative stress and apoptosis were assessed.

BBR significantly ameliorated cardiac dysfunction and histopathological damage caused by diabetic cardiomyopathy. This treatment also elevated serum superoxide dismutase levels while decreasing malondialdehyde levels. The anti-apoptotic activity of BBR was evidenced by a decrease in TUNEL-positive cells and the percentage of apoptotic cells, as determined by flow cytometry, in conjunction with diminished levels of BCL2-associated X protein/B cell lymphoma 2 (BAX/BCL2) in heart tissues.

Mechanistically, BBR was found to ameliorate diabetic cardiomyopathy by upregulating the expression of myocardial methionine sulfoxide reductase A (MsrA) and concurrently suppressing cardiac CaMKII oxidation.

BBR alleviates diabetic cardiomyopathy by inhibiting myocardial apoptosis and oxidative stress.

[ConservativeMind]

Berberine increased superoxide dismutase (SOD), a key body antioxidant we make less of, as we age. I previously posted how taurine can augment natural processes to increase SOD.

The result is heart muscle cells are much less likely to die, with this help. Our heart muscle cells are generally believed to never be replaced, so limiting damage is thought to be the best we can do, today.

[ConservativeMind]

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[Ken Regis]

Wonderful

[dfwgator]

Great news for mice.

[NWFree]

I’m sorry I don’t have my smart ass doctor talk translator with me

[mikey_hates_everything]

[sauropod]

.

[thesligoduffyflynns]

Your post is priceless

Nathan Thurm is a big fav of mine to this day.😆😆😆😆

Famous words: “ I know that” 😂😂😂

[GreenHornet]

Berberine ameliorates diabetic cardiomyopathy in mice by decreasing cardiomyocyte apoptosis, oxidative stress

I can't tell you how many bar bets I've won because I knew that.

[Uncle Miltie]

Berberine is a chemical found in some plants like European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric.

Berberine is a bitter-tasting and yellow-colored chemical. It might help strengthen the heartbeat, which could benefit people with certain heart conditions. It might also kill bacteria, help regulate how the body uses sugar in the blood, and help reduce swelling.

https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine

[NWFree]

Thanks

[mikey_hates_everything]

Nathan Thurm and Ed Grimley are two of my favorites. Short is a genius.

[thesligoduffyflynns]

I muuuust say ....
😂🤣😂