Posted on 09/24/2023 7:18:42 AM PDT by ConservativeMind
Researchers have shown in a mouse model and lab cultures that a compound derived from hops reduces the abundance of a gut bacterium associated with metabolic syndrome.
Patients are considered to have metabolic syndrome if they have at least two of the following: abdominal obesity, high blood pressure, high blood sugar, low levels of "good" cholesterol, and high levels of triglycerides.
Researchers for years have been studying the potential health benefits of xanthohumol, a chemical found in hops, and its derivatives including tetrahydroxanthohumol. The latter is commonly abbreviated to TXN, the former to XN.
XN is a polyphenol, a type of abundant organic compound existing in plants and used for millennia by practitioners of traditional medicine. XN is one of the flavonoids—natural products found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine—that are well known for their positive effects on health.
Andrey Morgun demonstrated that TXN can combat metabolic syndrome by reducing the population of Oscillibacter species within the gut microbiome.
More than 1,000 different bacterial species comprise the human gut microbiome.
"We found TXN mainly works by reducing the abundance of gut microbes that promote inflammation in the adipose tissue's macrophage cells, and improving glucose metabolism," Morgun said.
Macrophage cells are large cells that are part of the immune system. Glucose metabolism, the body's ability to convert the sugar into fuel, generally suffers impairment as someone becomes obese, which in turn can lead to the person becoming more overweight.
Faulty glucose metabolism also negatively affects brain physiology and is at the root of multiple medical conditions including diabetes and heart disease.
"When exposed to a high-fat diet common to metabolic syndrome, Oscillibacter bacteria help prompt the inflammation of fatty tissue that drives the syndrome," Morgun said. "TXN serves to limit Oscillibacter species' numbers."
(Excerpt) Read more at medicalxpress.com ...
“It has previously been shown, both by us and other groups, that both the prenylated flavonoid, xanthohumol (XN), isolated from hops (Humulus lupulus L.), and its semi-synthetic derivative tetrahydroxanthohumol (TXN) reduce biomarkers associated with MetS in animal models of diet-induced obesity. Although both XN and TXN successfully reduce inflammation [9,10,11], obesity, hepatosteatosis, and insulin resistance [12,13,14,15,16], TXN attenuates these symptoms more effectively than XN [16].”
Xanthohumol is a less efficient producer of the same benefits, meaning you simply need more of it to get the exact same benefits.
Those darn phenols are acting up again.
Hmmm, interesting.
Hops = beer...Maybe that beer belly is a good thing?
Derived from hops ... HUH?
Then I’ll just get mine the old fashioned way.
I was wondering how that plays into this. Maybe some beer is good, but too much is too much? How much beer is too much?
(Note: I dislike beer very much, but my husband loves it.)
OkeeDokee, I wondered how long it would take for the hops=beer connection to come up. 5 comments. Not bad.
If the compound survives the brewing process here is something all of the specialty brewers to tout.
Especially before BudLight gloms onto it, please.
Interesting serendipity. I looked around on Amazon and saw a Hops Flower extract product where a commenter from 2018 said “I think it’s helping to reduce my belly fat...”.
Hops extracts were commonly sold as a patent medicine ( more than likely with a lot of alcohol mixed in)in the late 1800s/early 1900s
I don’t drink, other than the rare sip at a wedding, and I can’t stand beer, but I have tasted wheat beer, and it is very tasty. I’m assuming it has hops in it, but I don’t know. Aren’t hops what gives beer that bitter edge?
Wheat beers tend to lack bitterness, and they can be brewed with or without hops. - Mr. FF
Thanks for the info!
P.S. I know next to nothing about beer, so rely on hubby for information in that regard.
I don’t know much about spirits or wines either, other than my tastes run towards the expensive side.
YW
I’ll have another beer, please.
Thanks.
bfl
So your saying that beer is still the elixir of life?
Thahn you for posting this........could be HUGE HELP.
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