Posted on 05/20/2023 9:39:19 AM PDT by ConservativeMind
Researchers have identified 10 pesticides that significantly damaged neurons implicated in the development of Parkinson's disease.
While environmental factors such as pesticide exposure have long been linked to Parkinson's, it has been harder to pinpoint which pesticides may raise risk for the neurodegenerative disorder. Just in California, there are nearly 14,000 pesticide products with over 1,000 active ingredients registered for use.
Through a novel pairing of epidemiology and toxicity screening researchers were able to identify 10 pesticides that were directly toxic to dopaminergic neurons. The neurons play a key role in voluntary movement, and the death of these neurons is a hallmark of Parkinson's.
Further, the researchers found that co-exposure of pesticides that are typically used in combinations in cotton farming were more toxic.
The researchers were able to determine long-term exposure for each person and then, using what they labeled a pesticide-wide association analysis, tested each pesticide individually for association with Parkinson's. From this untargeted screen, researchers identified 53 pesticides that appeared to be implicated in Parkinson's.
The 10 pesticides identified as directly toxic to these neurons included: four insecticides (dicofol, endosulfan, naled, propargite), three herbicides (diquat, endothall, trifluralin), and three fungicides (copper sulfate [basic and pentahydrate] and folpet). Most of the pesticides are still in use today in the United States.
Aside from their toxicity in dopaminergic neurons, there is little that unifies these pesticides. They have a range of use types, are structurally distinct, and do not share a prior toxicity classification.
The lab work is focused on distinct effects on dopamine neurons and cortical neurons, which are important for the movement and cognitive symptoms in Parkinson's patients, respectively. The basic science is also expanding to studies of pesticides on non-neuronal cells in the brain—the glia—to better understand how pesticides influence the function of these critical cells.
(Excerpt) Read more at medicalxpress.com ...
He says all his partying may have done major damage
It's sad we're lied to so much that we can't trust anything anymore. An authority pretending to know more than they really do is the most popular lie, and causes the most damage.
AI and robots have a bright future. AI will be a tool to challenge all the lies we don't have the time and resources to do ourselves. Robots can replace disease prone field farmworkers, and reduce spiraling social costs. Further, robots (some with laser beams mounted on their heads) could replace most chemicals used in insect and weed control. Farming will look very different 50 years from now.
In psychiatry, they have recognized copper toxicity as a cause of depression and anxiety.
That’s why you should never make hot drinks or cook with faucet hot water if you have copper water pipes. Hot water leaches more copper than cold water.
********************************
Copper Toxicity: A Common Cause of Psychiatric Symptoms
Elevated copper is linked to psychiatric and autoimmune conditions.
Posted September 11, 2017
tives containing estrogen, our ubiquitous exposure to xeno-estrogens (chemical compounds that mimic estrogen found in plastics and petrochemicals), and growth hormones fed to animals, as well as copper fungicides and widespread zinc deficiency secondary to malabsorption related to compromised gut health. (The relationship between copper, zinc and estrogen will be explained below.)
Here is a short list of psychiatric symptoms and traits associated with copper overload:
Hyperactivity, academic underachievement, learning disabilities, ADHD, autism, skin sensitivity to tags in shirts or rough fabrics, intolerance to estrogen and birth control pills, onset during puberty, pregnancy or menopause, white spots on fingernails, skin intolerance to cheap metals, emotional meltdowns and frequent anger, ringing in ears, sensitivity to food dyes and shellfish, high anxiety, depression, poor immune function, sleep problems, poor concentration and focus, low dopamine activity, and elevated activity of norepinephrine and adrenaline.
Other medical conditions associated with copper overload include acne, allergies, Candida overgrowth, hypothyroidism, anemia, hair loss, chronic fatigue and fibromyalgia, migraines and male infertility.
The reason that copper is linked with such a long and varied list of conditions is that it is absolutely essential to the proper functioning of the immune system, the endocrine system, and the nervous system.
Copper is important for regulating the synthesis of neurotransmitters that mediate psychiatric symptoms. It is a co-factor in the chemical reaction that converts dopamine to norepinephrine. When copper levels are high, more norepinephrine and epinephrine (adrenaline) are synthesized from dopamine, which can causes feelings of agitation, anxiety and panic, overstimulation, racing thoughts, restlessness, and insomnia. In other words, it has an amphetamine-like effect, revving the nervous system into a state of overdrive. Consider that copper is often used in electrical wires because it conducts electricity well, and likewise increases nerve transmission, which is an electrical chemical process.
Chondrial dysfunction have disorders of copper metabolism.
Copper overload is particularly common in women. Estrogen can cause copper retention and accumulation, which can eventually result in toxicity. Hormonal events such as menarche, pregnancy or menopause can trigger it. These days when a patient tells me about a history of postpartum depression, severe PMS, dysmenorrhea or adverse effects related to the prescription of oral contraceptives, I immediately suspect copper overload.
Copper promotes the formation of blood vessels (angiogenesis) and when copper levels are elevated, it can predispose an individual to endometriosis and fibroid tumors, as well as increase the blood supply to other types of tumors. Excess copper can accumulate in the liver and impair its capacity for detoxification, which can result in chemical sensitivities.
There is commonly an inverse relationship between zinc and copper in the body. Often when a patient has elevated copper, the zinc level is low. Zinc is another mineral essential to cellular function, regulation of the immune system, wound healing, and synthesis of neurotransmitters.
An important ingredient in the treatment of copper overload is supplementation with zinc. This must be done very slowly and carefully, because zinc mobilizes copper stores. During this process, a person can initially feel even more anxious and symptomatic.
Anti-oxidants are also used in the treatment of copper toxicity, as well as the elements molybdenum and manganese, and amino acids which promote metallothionein production. Metallothionein is another protein which binds heavy metals in the blood, and which is important for regulation of zinc and copper metabolism.
It’s important to find a trained practitioner to help you with this process. A good resource is the Practitioner’s Page of the Walsh Research Institute website.
Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis
Qingtao Jiang et al. Gynecol Obstet Invest. 2021.
https://pubmed.ncbi.nlm.nih.gov/34126621/
Conclusion: Our research generally indicated circulating copper level in PCOS sufferers was significantly higher than normal controls. Large-scale studies are still needed to elucidate the clear relation between copper status and etiology of PCOS.
The normal range for total copper in the blood is 62 to 140 micrograms per deciliter (mcg/dL). A low amount of copper could mean that you have: Kidney disease. A nutritional deficiency.
Per the above link:
Total Copper (Blood)
Does this test have other names?
Total copper serum test
What is this test?
This test measures the total amount of copper in your blood. Normally most of the copper in your blood is carried by a protein called ceruloplasmin.
Adults have 50 to 120 milligrams (mg) of copper in their body, mostly in muscle and the liver. Copper helps make melanin, bone, and connective tissue. It also helps with many other processes in your body. You normally get copper through your diet, in foods, such as liver and other organ meats, seafood, beans, and whole grains. You get rid of copper in your bowel movements and urine.
Many health problems can disrupt normal copper levels. This can cause you to have too little copper (copper deficiency) or too much copper (copper toxicity).
Too much copper can be toxic. You can get too much copper from dietary supplements or from drinking contaminated water. You can also get too much copper from being around fungicides that have copper sulfate. You can also have too much copper if you have a condition that stops the body from getting rid of copper. For example, Wilson disease keeps the liver from storing copper safely and from sending copper out of the body in your stool. Extra copper in the liver overflows and builds up in the kidneys, brain, and eyes. This extra copper can kill liver cells and cause nerve damage. Wilson disease is fatal if untreated. Extra copper can also interfere with how your body absorbs zinc and iron.
Why do I need this test?
You may need this test if you have symptoms of either copper deficiency or copper toxicity.
Symptoms of copper deficiency can include:
Anemia
A low level of a type of white blood cells called neutrophils (neutropenia)
Osteoporosis
Paleness
Hair with less pigment than normal
Children with copper deficiency through malnutrition or another condition may have aneurysms in the blood vessels, central nervous system problems, stunted growth, poor muscle tone and muscle weakness, and hypothermia.
Symptoms of copper toxicity include:
Belly pain
Diarrhea
Vomiting
In more severe forms, copper toxicity can lead to:
Heart and kidney failure
Liver damage
Brain disease or disorder
Death
Symptoms of Wilson disease include:
Anemia
Low white blood cell count
Belly (abdominal) pain, dark urine, light-colored stools, poor appetite, yellowing of eyes or skin (jaundice) when the liver is affected
Kayser-Fleischer rings. These are brown rings around the cornea that are visible to a healthcare provider during an eye exam.
Mental illness
Copper sulfate is widely used, by home gardners, to fight tomato / potato blight.
" Through a novel pairing of epidemiology and toxicity screening researchers were able to identify 10 pesticides that were directly toxic to dopaminergic neurons.
The neurons play a key role in voluntary movement, and the death of these neurons is a hallmark of Parkinson's."
"Further, the researchers found that co-exposure of pesticides that are typically used in combinations in cotton farming were more toxic."
"The researchers were able to determine long-term exposure for each person and then, using what they labeled a pesticide-wide association analysis,
tested each pesticide individually for association with Parkinson's.
From this untargeted screen, researchers identified 53 pesticides that appeared to be implicated in Parkinson's."
"The 10 pesticides identified as directly toxic to these neurons included:
four insecticides (dicofol, endosulfan, naled, propargite),
three herbicides (diquat, endothall, trifluralin), and
three fungicides (copper sulfate [basic and pentahydrate] and folpet).
Most of the pesticides are still in use today in the United States."
"Aside from their toxicity in dopaminergic neurons, there is little that unifies these pesticides.
They have a range of use types, are structurally distinct,
and do not share a prior toxicity classification."
I’m going to post this on the Natural Health thread, great info. I got poisoned by a huge dose of diazanon by a very bad neighbor years ago and it cause a miscarriage, and life long chronic conditions that I suffer from to this day. The pesticide diazanon is now not sold to consumers, but farmers use it, and it is an ingredient is mixtures sold to consumers.
There are many ways to get rid of bad bugs than highly toxic pesticides, many of which are neurotoxic.
Very good point. AI could see the truth without the agenda and help in many areas of research or analysis of research.
Off topic : Take DDT as an example. Not sure how bad it really was in the environment but silent spring was another example of city people hyping something they really didn’t understand. Like the green/environmental worship now with them voting for plain stupidity since living in cities removes them from real nature/environment. The banning of DDT kills over a million people a year in direct impact due to ineffective insect control. Almost eliminated multiple insect borne diseases.
My favorite arguments are DDT and tobacco.
Environmentalists banning DDT= racism because poor minorities die due to malaria ….
Native Americans (BIPOC) killed 100s of million Europeans addicting them to tobacco/Coca related plants hence the real genocide is them on us.
So are, any of those something I might pick up at Home Depot on Friday and out in my lawn Sunday morning?
Just a couple are normally available.
There’s no doubt in my Military Mind that ‘science’ has been poisoning us and out food sources for decades.
And will continue unabated. :(
Educate yourself, arm yourself, prepare yourself, grow your own if you can. Move to the hills!
We are on our own.
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