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Researchers identify 10 pesticides toxic to neurons involved in Parkinson's
Medical Xpress / University of California, Los Angeles / Nature Communications ^ | May 17, 2023 | Kimberly C. Paul et al

Posted on 05/20/2023 9:39:19 AM PDT by ConservativeMind

Researchers have identified 10 pesticides that significantly damaged neurons implicated in the development of Parkinson's disease.

While environmental factors such as pesticide exposure have long been linked to Parkinson's, it has been harder to pinpoint which pesticides may raise risk for the neurodegenerative disorder. Just in California, there are nearly 14,000 pesticide products with over 1,000 active ingredients registered for use.

Through a novel pairing of epidemiology and toxicity screening researchers were able to identify 10 pesticides that were directly toxic to dopaminergic neurons. The neurons play a key role in voluntary movement, and the death of these neurons is a hallmark of Parkinson's.

Further, the researchers found that co-exposure of pesticides that are typically used in combinations in cotton farming were more toxic.

The researchers were able to determine long-term exposure for each person and then, using what they labeled a pesticide-wide association analysis, tested each pesticide individually for association with Parkinson's. From this untargeted screen, researchers identified 53 pesticides that appeared to be implicated in Parkinson's.

The 10 pesticides identified as directly toxic to these neurons included: four insecticides (dicofol, endosulfan, naled, propargite), three herbicides (diquat, endothall, trifluralin), and three fungicides (copper sulfate [basic and pentahydrate] and folpet). Most of the pesticides are still in use today in the United States.

Aside from their toxicity in dopaminergic neurons, there is little that unifies these pesticides. They have a range of use types, are structurally distinct, and do not share a prior toxicity classification.

The lab work is focused on distinct effects on dopamine neurons and cortical neurons, which are important for the movement and cognitive symptoms in Parkinson's patients, respectively. The basic science is also expanding to studies of pesticides on non-neuronal cells in the brain—the glia—to better understand how pesticides influence the function of these critical cells.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: parkinsons; pesticides
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Out of thousands of pesticides (insecticides, herbicides, and fungicides), only ten were found to be directly toxic to neurons tied to Parkinson’s.

Insecticides:

- dicofol

- endosulfan

- naled

- propargite

Herbicides:

- diquat

- endothall

- trifluralin

Fungicides:

- copper sulfate [basic and pentahydrate]

- folpet

Be careful with these.

1 posted on 05/20/2023 9:39:19 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 05/20/2023 9:39:51 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

a lot of people think copper sulfate does not sound too bad...but it is..


3 posted on 05/20/2023 9:47:32 AM PDT by BereanBrain
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To: ConservativeMind

Darn

I’ve been using manyy of those for years and still use copper sulfate.

We use copper sulfate in the pond to kill algae and in the hoof trough for the cows to walk through after milking. It kills foot rot for cows.

I used to use it with sulpher to kill diseases on the grape vineyard.


4 posted on 05/20/2023 9:47:56 AM PDT by tired&retired (Blessings )
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To: tired&retired

Maybe I can blame my typing errors on that!


5 posted on 05/20/2023 9:48:52 AM PDT by tired&retired (Blessings )
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To: ConservativeMind

My friend’s dad loved to garden and used lots of chemicals on his plants. He died a slow death from Parkinson’s. It’s like dementia in reverse. He was very alert but in the end he could only lie in bed. Terrible.


6 posted on 05/20/2023 9:53:29 AM PDT by packagingguy
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To: ConservativeMind

My late father, born 1927, succumbed to Parkinson’s in 2007.

He was an avid DDT proponent in the 1960s before it was shut down. Had a hired sprayer come in and cover the backyard and wooded area in CT on a 1-acre parcel. To this date, don’t know whether DDT is this kind of pesticide. I would be skeptical about any online research I do today.


7 posted on 05/20/2023 9:59:09 AM PDT by George from New England
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To: tired&retired

Copper is great if you leave some bare wires in the tray of your a/c system. Kill the algae therein and avoid the clogged drain pipes.


8 posted on 05/20/2023 10:00:17 AM PDT by George from New England
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To: packagingguy

My brother-in-law died from Parkinsons. He was a farmer.


9 posted on 05/20/2023 10:00:28 AM PDT by fretzer
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To: George from New England

There was a scientist that often took spoonfuls of DDT, to show it was harmless.


10 posted on 05/20/2023 10:02:36 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
The research was conducted by a select group of tort lawyers, federal judges, and Deep State bureaucrats.

This is how the neo-Marxist Left will destroy traditional farming.

Mom, can I have some more insect cereal?

11 posted on 05/20/2023 10:09:04 AM PDT by zeestephen (Trump "Lost" By 43,000 Votes - Spread Across Three States - GA, WI, AZ)
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To: ConservativeMind

When I get Parkinson symptoms, I take 200mg of Vitamin B1. They disappear.


12 posted on 05/20/2023 10:14:45 AM PDT by aimhigh (THIS is His commandment . . . . 1 John 3:23)
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To: ConservativeMind

It’s amazing I know hundreds of farmers and I know it’s anecdotal but not one that I know of living or dead had Parkinson’s disease.


13 posted on 05/20/2023 10:20:21 AM PDT by tiki (Electiongate)
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To: ConservativeMind

How did Micheal J. Fox end up with Parkinson’s. I doubt he ever mowed his own law let alone get near any of these pesticides? I know a person recently diagnosed with Parkinson’s and he has spent the past 30+ years in a hospital, sure not out farming, gardening, or spraying any type of pesticide.


14 posted on 05/20/2023 10:21:32 AM PDT by Just mythoughts (Psalm 2. Why do the heathen rage, and the people imagine a vain thing?)
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To: ConservativeMind

I have a tree root out back that won’t stop shooting up suckers for 3 years! Before spring sprung I practically covered the ground and stump with copper sulfate crystals. Turned the ground blue when I watered it.2 weeks ago the wife got all kinds of landscaping stuff and she planted strawberry’s in wash tubs where it used to grow. The sun came out and all those suckers wilted over and died. I hope they had parkinson’s, I have been fighting that stump for 3 years!


15 posted on 05/20/2023 11:13:08 AM PDT by Delta 21 (MAGA Republican is my pronoun.)
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To: Delta 21

The wifey wouldn’t let you dynamite the stump?


16 posted on 05/20/2023 11:30:55 AM PDT by null and void (Men Are from Mars, Women Are from Venus, Wookies Are From Kashyyyk)
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To: ConservativeMind

Parkinson’s Disease is a Presumptive Illness from exposure to the Rainbow Herbicides. VA Compensable.


17 posted on 05/20/2023 11:40:11 AM PDT by donozark (The Biden crime family makes Al Capone look like a piker.)
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To: ConservativeMind

Since they tried to tie them to cotton farming they should’ve taken a look see. California and Pennsylvania have the most cases. No where near the southern cotton belt


18 posted on 05/20/2023 2:16:45 PM PDT by Nifster ( I see puppy dogs in the clouds )
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To: tired&retired

I like it. May steal it


19 posted on 05/20/2023 2:18:11 PM PDT by Nifster ( I see puppy dogs in the clouds )
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To: tiki

I know lots of farmers as well

I know one man who was diagnosed with Parkinson’s and eventually died from it. Course he was 88 when he passed


20 posted on 05/20/2023 2:21:26 PM PDT by Nifster ( I see puppy dogs in the clouds )
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