Posted on 04/28/2023 5:25:16 AM PDT by Red Badger
As a growing number of overweight Americans clamor for Ozempic and Wegovy — drugs touted by celebrities and on TikTok to pare pounds — an even more powerful obesity medicine is poised to upend treatment.
Tirzepatide, an Eli Lilly and Co. drug approved to treat type 2 diabetes under the brand name Mounjaro, helped people with the disease who were overweight or had obesity lose up to 16% of their body weight, or more than 34 pounds, over nearly 17 months, the company said on Thursday.
The late-stage study of the drug for weight loss adds to earlier evidence that similar participants without diabetes lost up to 22% of their body weight over that period with weekly injections of the drug. For a typical patient on the highest dose, that meant shedding more than 50 pounds.
Having diabetes makes it notoriously difficult to lose weight, said Dr. Nadia Ahmad, Lilly’s medical director of obesity clinical development, which means the recent results are especially significant. “We have not seen this degree of weight reduction,” she said
Based on the new results, which have not yet been published in full, company officials said they will finalize an application to the U.S. Food and Drug Administration for fast-track approval to sell tirzepatide for chronic weight management. A decision could come later this year. A company spokeswoman would not confirm whether the drug would be marketed for weight loss in the U.S. under a different brand name.
(Excerpt) Read more at 12ft.io ...
Eat recklessly, take a pill, lose weight.
What could go wrong?
/s
No but I’m seriously considering trying chickpea flour. A side tragedy in all this is I got a pasta machine near the end of last year and then this surprise diabetes ruined it.
It was a surprise because for at least 20 years I had been baffling doctors because my blood pressure, cholesterol and A1C were all perfect and I looked like I should be dead from clogged everything, I also ate like there was no tomorrow. Fry it and smother it in gravy and I’d eat it. I peaked last year at 454 lbs (I’m 6’6” so I looked heavy but not nearly as fat as I was) and I think my body decided it was done with my shenanigans and hit the brakes.
I still don’t see a difference in the mirror but I’m wearing clothes that haven’t fit for years. If I get concerned that I’m not making progress I try on pants I couldn’t button a couple years ago, I can’t even belt them tight enough to stay up now.
That, my FRiend, is "the hospital 'diet'". Ironically, during my father's brief stay in both the hospital and the rehab facility, his T2 was reversed, lost 40lbs and blood sugar was on the LOW side. But of course, he reverted back to his original weight and bad habits once he'd healed.
Ok. Have to ask (mostly rhetorical):
Are you reserving these drugs for the morbidly obese, or are they being dispensed to the ‘merely’ obese?
As well, what is the maximum term of treatment, or is it open-ended?
They served the ‘rubber chicken’ twice a day.
I stopped eating it after a couple of days.
I think they saved it and just kept putting it back on my tray every day............... 🤷♂️
Bottom line is, you can reverse metabolic disorder with diet and just a wee bit of exercise.
How I did it:
- OMAD - One meal a day. I eat one meal in the evening. No fast carbs. Any carbs in my meal come from vegetables low carb veggies.
- Effort to walk at least 10,000 steps. Easiest to fit these steps into your current lifestyle. Do things like park further from the store, take a couple extra laps in the store, take the stairs if you can, hunt mushrooms when not in season :).
Your body was taught to eat three times a day. It doesn’t need food that often if you feed it protein and slow carbs, like a caveman. I won’t kid you, it is hard to retrain your body to only get hungry around 4:00PM (for me), but it will adapt.
After one year, my A1C was 5.5 and my cholesterol was around 100. These numbers and my weight are steady after 5 years. My PCP was consulted and approved, but she still asks if I eat a low cholesterol diet. Guess she can’t help herself.
Pasta is freakishly easy to make especially if you get a hand crank machine. I eat in about once every other week or so and it fits in well, especially if it’s the side dish. You need about 100 g of pasta flour (this is usually an Italian import) and one large egg. You can get three ish one cup servings out of that.
I have a friend who is a nurse. She watches other nurses eat the donut and then up the insulin. If she suggests an apple she’s fat phobic.
Meth is probably a lot cheaper
Everything you just said is in here.................
https://www.amazon.com/Undoctored-Health-Failed-Become-Smarter/dp/1623368669
I think it is working more because I already had changed much of my eating habits, and my body just needed help getting over the hill. I still have a lot more weight to lose.
I don’t trust big pharma and try to stay off as many medications as they want to throw at me. Too many side effects, so then you take something else to fix that issue. No thank you.
“people who have not been able to lose before”
Had those people tried keto & fasting?
And what happens when the injections stop?
“It seems for me that almost anything that comes in a box is dangerous”
Could probably add “Anything that comes in a bag and doesn’t require refrigeration is dangerous”.
That’s a rhetorical question, right?
The drug companies announce a weight loss wonder drug on the same day.
Coincidence?
right now the use for obesity is off label so there are no real guidelines how obese one is to use it. Treatment is open ended. It appears that if the med is stopped altogether weight cones back. It may be a smaller dose is necessary indefinitely to maintain the weight loss, which would make sense since we are treating metabolic syndrome. You cannot stop blood pressure medications once your blood pressure is normalized on medication. The disease is controlled not cured unfortunately
Anything require me work in addition to the medication. you are doing a wonderful job and reaping the benefits. Keep up the good work
Not a pill an injection. And what you eat undoubtedly plays into the success. I don’t think anyone argues there are different metabolisms. There is finally good news for those who have struggled with weight their entire life
Yes, I had tried keto and fasting. Both worked for about 40-60 pounds and then I would hit a plateau and no matter what I would eat or not eat, the weight would slowly return. But, I was not put on this for weight, but for blood sugar that was out of control. The meds and diet would not control it. Sadly, I still need to lose a bit more before I can start walking and working toward adding real exercise to the mix.
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