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A new combination therapy regimen shows promising results for prostate cancer (37% less risk of progression or death)
Medical Xpress / Huntsman Cancer Inst / Am Soc of Clinical Onc Genitourinary Cancers Symposium ^ | March 17, 2023 | Neeraj Agarwal, MD et al

Posted on 03/21/2023 8:25:52 AM PDT by ConservativeMind

TALAPRO-2, a study led by Neeraj Agarwal, MD, demonstrated that using TALZENNA, in combination with XTANDI, may reduce the risk of disease progression or death by 37%.

According to the National Cancer Institute, prostate cancer is the most common cancer and second leading cause of cancer death among men in the United States. Castration-resistant prostate cancer, or CRPC, is a late state of prostate cancer that continues to grow despite androgen blockade.

TALAPRO-2 combines two oral medications, TALZENNA and XTANDI, to treat metastatic prostate cancer. The trial looks at the effectiveness of adding TALZENNA to the standard treatment of XTANDI, an androgen receptor blocker that prevents male hormones from feeding the cancer. TALZENNA is a PARP inhibitor typically used to treat breast cancer.

During the global study, the treatment plan for each of the participants was randomly selected. Some received the combination of the two drugs, while others received the standard treatment of XTANDI and a placebo pill. Huntsman Cancer Institute's clinical trials team played a critical role in the monitoring of participants enrolled at the institute. The comparison of side effects and results between the two groups is a key feature of all Phase III trials.

"As a physician, I want my patients to be able to enjoy life while being treated for cancer," says Agarwal. "Clinical trials help us find better cancer treatments with fewer side effects. Those who are impacted by cancer can have hope that their treatment is constantly improving."

Phase III trials are the last phase before the FDA can approve a new treatment. The FDA decision on this investigatory drug combination is expected in 2023.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; metastaticcancer; prostate
Both therapies are available today, but would need to be used off label, it appears, for now.
1 posted on 03/21/2023 8:25:52 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 03/21/2023 8:26:27 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I was lucky enough to have a good doctor who discovered my prostate cancer while in stage 1. That was in 2012 and so far no sign of a recurrence after seeds and radiation therapy.


3 posted on 03/21/2023 11:33:22 AM PDT by armydawg505
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To: ConservativeMind

Thanks! I suspect that this would be of interest to a lot of FR posters.


4 posted on 03/21/2023 6:17:12 PM PDT by Pete from Shawnee Mission ( )
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To: ConservativeMind

Bookmark


5 posted on 03/22/2023 8:16:57 AM PDT by Irish Eyes
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