Posted on 03/17/2023 6:47:25 AM PDT by ConservativeMind
Decline in the hypothalamic Menin may play a key role in aging, according to a study. The findings reveal a previously unknown driver of physiological aging, and suggest that supplementation with a simple amino acid may mitigate some age-related changes.
Leng and colleagues showed that Menin, a hypothalamic protein, is a key inhibitor of hypothalamic neuroinflammation. They observed that the level of Menin in the hypothalamus, but not astrocytes or microglia, declines with age.
Another change was a decline in levels of the amino acid D-serine, known to be a neurotransmitter and sometimes used as a dietary supplement. The authors showed this decline was due to loss of activity of an enzyme involved in its synthesis (which was in turn regulated by Menin).
The authors delivered the gene for Menin into the hypothalamus of elderly (20-month-old) mice. Thirty days later, they found improved skin thickness and bone mass, along with better learning, cognition, and balance, which correlated with an increase in D-serine within the hippocampus, a central brain region important for learning and memory.
Remarkably, similar benefits on cognition, though not on the peripheral signs of aging, could be induced by three weeks of dietary supplementation with D-serine.
Nonetheless, Leng said, "We speculate that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and Menin may be the key protein connecting the genetic, inflammatory, and metabolic factors of aging. D-serine is a potentially promising therapeutic for cognitive decline."
Leng adds, "Ventromedial hypothalamus (VMH) Menin signaling diminished in aged mice, which contributes to systemic aging phenotypes and cognitive deficits. The effects of Menin on aging are mediated by neuroinflammatory changes and metabolic pathway signaling, accompanied by serine deficiency in VMH, while restoration of Menin in VMH reversed aging-related phenotypes."
(Excerpt) Read more at medicalxpress.com ...
D-serine is a converted form that our bodies once made from L-serine. It appears something, perhaps the loss of an enzyme they note that Menin influences, stops it, which causes all sorts of serine use processes from working—including the making of serine and cysteine.
Serine is the precursor for glycine and cysteine to be made in our bodies. Other studies have shown our bodies stop making enough glycine and cysteine, as we age, and supplementing glycine and cysteine, via powder form, is what GlyNAC does, which is glycine and N-acetyl cysteine. Studies have shown amazing benefit with GlyNAC, and I’ve posted a few of those on Free Republic. My wife and I take glycine and NAC, as a result.
So it doesn’t immediately look like adding L-serine is that helpful, and D-serine is available, but is a niche supplement and can be hard to find. Additionally, one site I reviewed suggests some types of cancer cells like D-serine, but I would suggest as people age, a small supplement of D-serine would likely just make up for what the body now isn’t properly making.
However, GlyNAC is easy enough to formulate at home, with just equal amounts of glycine and NAC. Nestle’s Celltrient site sells GlyNAC in packets of 600 mg glycine and 600 mg NAC, as “Cellular Protect,” if you want it, premade.
I’m confused. Where does one get Menin? And why buy Nestle’s Celltrient site sells GlyNAC in packets of 600 mg glycine and 600 mg NAC, as “Cellular Protect,” ??? Is it a precursor to Menin that the body makes?
Both D-serine and L-serine (the commonly available form of serine) help multiple processes we need, including manufacture of glycine and cysteine in our bodies. However, L-serine conversion to D-serine is lacking in older people.
Since you can't easily find D-serine and L-serine appears to not work correctly, you can at least supplement glycine and cysteine, which are also required in our bodies and also are no longer being properly made in our bodies. Supplementing glycine and cysteine has already been proven to greatly benefit older people.
So you can get a good amount of benefit from what is commonly available, even if you can't find what is not commonly available.
Then please tell all the cancer and heart attack sufferers in your life to just give it up and not get treated.
After all, as you state, no one can defy God for their entropic conditions.
This wax according to “a study “
I couldn’t find the nane of the study or who did it
I put the name of “who did it” in the dang title area of this thread! Can you not even stoop to read that, before commenting?
The link to the complete study, which is free to read, is at the bottom of the page of the link I also provided, above.
Can you find your head, this morning?
‘He who isn’t busy being born is busy dying’..Bob Dylan
PS. Live a healthy life but none of us exits the planet
vertical and breathing.
God did give man wisdom, and part of the wisdom. Was the abi,ity to study and find cures and help for certain diseases to increase life expectancy, but God for sure knows the day and hour, we don’t, and must do all we can to try to prolong our stay here, lewv8ng the inevitable in God’s hands. God provided the wisdom and such for mankind to benefit from, and possibly live longer and healthier, from discoveries. The end comes at our appointed times, but our appointed times might be based on the fact that we ate healthier, and too, Care of ourselves
Are there any natural forms of L-serine and/or and D-serine? Fruits and/or veggies are what I’m thinking...
Would DHEA supplements be precursors to all of these amino acids?
bttt
However, L-serine conversion to D-serine is lacking in older people.
~~~~~
I am under the impression that only left-folded supplements (L-serine) are digestible. That would mean that supplementing with a right-folded amino acid (D-serine) would do no good.
L-serine is a naturally occurring dietary amino acid. It is abundant in soy products, sweet potatoes, eggs, meat, and some edible seaweed.
d-serine is contained in fermented foods and marine invertebrates
From above:
“Remarkably, similar benefits on cognition, though not on the peripheral signs of aging, could be induced by three weeks of dietary supplementation with D-serine.”
Bookmark
Wow
Was there a reason to be rude?
So it was a study done by Chinese.
Got it.
Thank you
No.
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