Posted on 02/10/2023 9:34:10 PM PST by ConservativeMind
The newest vitamin B3 family member, nicotinamide riboside (NR) has been found to have beneficial effects on mitochondria in the human muscle. Currently, mitochondrial dysfunction cannot be treated. Recent findings encourage further investigation of whether this vitamin B3 form could serve as a potential therapeutic option for mitochondrial dysfunction.
In a recent twin study, it was found that nicotinamide riboside (NR) increased the number of mitochondria in the muscle after long-term administration. In addition, NR improved the gut bacterial composition and increased the blood NAD+ concentrations.
"Our study demonstrated the beneficial effects of long-term supplementation of NR on NAD+ metabolism, and particularly on muscle mitochondria and gut microbiota in humans," Pirinen says.
Blood, lipid, muscle and stool samples were collected before and after NR supplementation from the identical twins who participated in the study. The samples were analyzed by measuring NAD+ metabolites in the blood, investigating the amount of mitochondria in tissues and determining the microbiota composition of the stool samples.
The beneficial effects of NR were observed in both leaner and heavier co-twins. In other words, NR supplementation is likely to benefit all individuals regardless of their weight.
A future drug for treating mitochondrial and gut microbiota imbalance? NR was also found to affect several muscle tissue functions. It increased the differentiation of muscle stem cells and modified gene expression by modulating DNA methylation, i.e., an incorporation of methyl groups to DNA.
Based on the findings, NR supplementation appears to be a promising therapeutic option to be studied in diseases characterized by gut microbiota imbalance and/or muscle mitochondrial dysfunction, such as sarcopenia, which is age-related muscle loss. According to the authors of this study, long-term administration of NR should be investigated further in clinical trials, although in carefully selected patients, as NR was found to impair insulin sensitivity.
(Excerpt) Read more at medicalxpress.com ...
Why would you not take NAD+ directly instead of a precursor? I purchased a supply of it but haven’t started taking yet.
Remember, precursors are typically substances that help create the end product right where existing processes currently place or need it.
the great Dr. Mercola advocated this supplement for us elderly folks as beneficial for dna repair, cancer prevention, possible help with ‘long covid’, spike protein damage, etc., explaining it’s potential benefits for cell health in detail with a specialist researcher into NAD+ on one of his many podcasts.
i started about half a year ago. so far so good.
I am actually just finishing up a bottle of nicotinamide pantothenate right now.
If anyone is interested, there are almost “expired” bottles of nicotinamide pantothenate available from a seller on eBay for $6.89 + $5.85 shipping. 120 capsules. NAD+ is a LOT more expensive.
Niacin vs Nicotinamide vs Nicotinamide Riboside
Niacin, nicotinamide, and nicotinamide riboside are all forms of vitamin B3.
Its seems Vitamin b3 NR and NMN all have slightly different effects on the body.
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