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Green tea and resveratrol reduce Alzheimer's plaques in lab tests
Medical Xpress / Tufts University / Free Radical Biology and Medicine ^ | Nov. 2, 2022 | Taylor McNeil / Isabella A. Silveira et al

Posted on 11/02/2022 9:33:23 PM PDT by ConservativeMind

Researchers earlier this year showed that the common herpes virus could induce plaques in the brain associated with Alzheimer's disease.

Now, researchers are working to understand what might slow progression of the disease. They have tested 21 different compounds in Alzheimer's-afflicted neural cells in the lab, measuring the compounds' effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer's.

The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects.

Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer's induced by the herpes virus. But finding a compound "that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer's, you might still see some kind of improvement," says Dana Cairns.

The initial screen found five compounds had "really robust prevention of these plaques," she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.

"We got lucky that some of these showed some pretty strong efficacy," Cairns said. "In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week."

Cairns cautioned that seeing effects in the lab "doesn't always necessarily translate to what you might see in a patient." Some compounds do not cross the blood-brain barrier, which would be essential in the case of Alzheimer's, and some have low bioavailability, meaning they are not readily absorbed into the body or bloodstream.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; amyloid; betaamyloid; citicoline; covidtreatment; greentea; plaques; resveratrol
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To: ground_fog

Sol-tea. I will look into that.


21 posted on 11/03/2022 9:40:41 AM PDT by lee martell
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To: ckilmer
We have taken citicoline (also known as CDP Choline) and another brain supplement called Alpha GPC. They do seem to make our brains quicker, and both forms cross the blood-brain barrier, while some forms of choline do not, and the body needs to convert them for brain use. There's plenty of information on these, so I won't retype any of it, here.

My wife does take citicoline from time to time, but I haven't for a while, but I don't have a problem with them, as studies showing potential TMAO issues from at least citicoline and also phosphatidyl choline were minor (Alpha-GPC was not checked, as I recall). I decided to take lecithin for phosphatidyl choline, for awhile rather than citicoline and Alpha-GPC. I stopped taking lecithin a few months back because I thought it was causing more absorption of some supplements than I had realized (lecithin is used to make substances liposomal).

I drink a good white tea relatively often, which has 60% of the EGCG of green teat, along with other antioxidants green tea has, and doesn't have. I prefer a larger amount of white tea over green tea or green tea supplements, of which taking doses supplied in EGCG capsules as a routine, when not addressing a temporary condition like COVID as a zinc ionophore, can become problematic with one's liver.

We no longer routinely take resveratrol, but still take half a curcumin pill a day (500 mg equivalent).

After finding ways to help our bodies as they used to work as children with GlyNAC for glutathione, taurine for superoxide dismutase (SOD), and Urolithin A for mitophagy cleanup, these appear a cleaner, definitely less problematic, way to address issues. The three amino acids (glycine, cysteine (NAC), and taurine are cheap and our bodies use them exactly where needed, inside and outside of cells. Urolithin A cleans up defective mitochondria, renewing old cells, making them younger.

In sum, we aren't healthy as children because we take green tea extract, but because our internal processes aren't yet broken. Make your body work like a child's by fixing defective processes, and you are doing far better than taking a lot of one-off supplements, and that is a safe, effective approach. If that can't address issues, then layer other supplements on top.

22 posted on 11/03/2022 10:19:50 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I’d love to try and develop a taste for green tea, but I keep forgetting to put the tea bags in the cup and to turn on the burner under the kettle...

Wish there was a Mr. Grean Tea maker to go along with my Mr. Coffee maker...


23 posted on 11/03/2022 1:43:49 PM PDT by SuperLuminal (Where is the next Sam Adams when we so desperatly need him)
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To: SuperLuminal

Try some white tea, which has 60% of the green tea EGCG and other antioxidants green doesn’t have.

It is a milder taste.


24 posted on 11/03/2022 1:49:51 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Seaplaner
"...supplements play a significant role. (So does CPAP, btw) ..."

.

Yup.
I take a number of select supplements AND use a CPAP machine also.

This 58 year old's memory is still slowly improving -
even 12 years after the traumatic brain injury.

My memory is getting better - as those of my age around me see
their's getting worse.

25 posted on 11/03/2022 4:22:13 PM PDT by GaltAdonis
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To: ground_fog

BKMK for Soltea when I get home. For some reason my computer here at work doesn’t like the website. It’s been pretty wonky lately, so not surprising.


26 posted on 11/03/2022 4:30:14 PM PDT by Mama Shawna
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To: ConservativeMind

In two weeks I’m 89, so it is probably a lost cause...🙁

I’ll get my wife to try the tea... She used to drink tea all the time... Now her primary focus, outside the family, is on coffee and slot machines...


27 posted on 11/03/2022 4:48:41 PM PDT by SuperLuminal (Where is the next Sam Adams when we so desperatly need him)
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To: SuperLuminal

If you have a Big Lots nearby, they have a bagged white tea we really like, and we drink that when we aren’t home (where we use loose silver needles tea from Davidson’s).

Look for “Touch Organic White Tea.”


28 posted on 11/03/2022 5:00:30 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: SuperLuminal
Look into the GlyNAC, taurine, and Urolithin A posts I have put up.

GlyNAC made 80 year olds healthier to the point they walked faster than 30 year olds, each at their normal walking gait.

29 posted on 11/03/2022 5:03:59 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: GaltAdonis
Good on ya' my good FRiend.

I anticipate more good news from you.

30 posted on 11/03/2022 6:45:09 PM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston Churchill)
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To: ConservativeMind

Mitopure is an expensive way to get Urolithin A into your system. You can also take pomegranite extract pills. However, I have not seen any studies to show the efficacy of pomegranite extract pills or what dosage you need to get the equivalent dose to Mitopure.

How do you get Urolithin A into your system?


31 posted on 11/04/2022 7:10:27 AM PDT by ckilmer (q)
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To: ckilmer

Pomegranate works for 40% of the population, according to a study, but it delivers small amounts of Urolithin A.

We have been getting it from Celltrient Strength, but an alternative is Time Line Nutrition.

Both retail sites have discounts available, and Amazon has a subscription discount, too.

I’ve mentioned these before, sir. 🙂


32 posted on 11/04/2022 7:33:23 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Seaplaner
"...I anticipate more good news from you. ..."

.

I'm a type 2 diabetic - and A1-C is a longer term measurement
of the severity of it.

The endocrinologists (diabetes doctors) always say to me:

"Get your A1-C below 7.1 and you are doing good."

As of a few weeks ago my A1-C number was in the mid 5s - (5.4 I think).
That's the kind of number you get from testing a NON-diabetic!
(Or a former diabetic.)

So yeah - I'll do my utmost to keep that good news flowing!

Have a good day!

33 posted on 11/04/2022 1:11:40 PM PDT by GaltAdonis
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To: ConservativeMind

I got a case of covid two months back. I tested negative after about 7 days. However, it seems to me that I have some lingering effects. Slight congestion. Not enough to cough. I went to give blood and found my iron was too low. I supplemented that back to normal and several weeks later I gave blood.
What supplements do you think will give a person the best chance of recovering easily from covid—or even not getting it.


34 posted on 11/10/2022 8:42:53 AM PST by ckilmer (q)
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To: ckilmer

My biggest personal recommendation is to beef up supplements that actually reverse aging issues. Young people don’t have any problems with COVID. Then, add in the items that we need, anyway. After that, things are optional and potentially helpful.

Also, it needs to be maintainable and in amounts that chronic use can’t cause other issues, to be a true preventable, in my opinion. Of course, if you are exposed to real COVID situation, you can up doses and take other substances, but I just don’t see benefit to always take the maximum of something largely only meant to help with some unknown future infection. Take a sustainable, safe approach, instead.

This means amino acids and minerals: GlyNAC (NAC was already a good thing to take, but you don’t want a bunch of excess NAC floating around in your body, because it directly counteracts some effects of many antioxidants people take), taurine (to increase superoxide dismutase (SOD)), normal to somewhat higher doses of minerals such as zinc, manganese, a little copper (all three help with making the final forms of SOD we need), boron, and magnesium.

Boron helps against COVID (I didn’t post this as a thread): https://www.sciencedirect.com/science/article/pii/S0946672X22000256

This means vitamins: 2,500-3,000 IU equivalent of Vitamin D, Vitamin C (time release) of 500 mg, and a B-complex or enhanced vitamin with active forms of the B vitamins (no need to go nuts on huge amounts of B vitamins, though).

Also antioxidants: Curcumin 500 mg.

We actually take all of these, every day. Of course, we take other items, too, but not to impact COVID, and we don’t actually take these for COVID, either, but they can help with it.

I had my blood tested last month and it’s at 34 ng/ml. Issues can start when you are above 40 ng/ml, so I’m perfectly happy where we appear to land with what is sustainable and not likely capable of causing other issues. I do know FLCCC says to get Vitamin D to 50 ng/ml, but they also encourage, fairly so, the vaccine for vulnerable people, along with other supplements and medicines for various stages of infection, such as black cumin seed, which we do not take unless we think we have a COVID infection. We would also take our iota-carrageenan nasal spray we made from a recipe we found, use a steam inhaler, etc., depending on what was going on.

I go by C19early.com for additional COVID insight, beyond FLCCC and a few other sites/regimens.

Hope this helps.


35 posted on 11/10/2022 9:36:09 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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