Posted on 11/02/2022 9:33:23 PM PDT by ConservativeMind
Researchers earlier this year showed that the common herpes virus could induce plaques in the brain associated with Alzheimer's disease.
Now, researchers are working to understand what might slow progression of the disease. They have tested 21 different compounds in Alzheimer's-afflicted neural cells in the lab, measuring the compounds' effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer's.
The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects.
Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer's induced by the herpes virus. But finding a compound "that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer's, you might still see some kind of improvement," says Dana Cairns.
The initial screen found five compounds had "really robust prevention of these plaques," she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.
"We got lucky that some of these showed some pretty strong efficacy," Cairns said. "In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week."
Cairns cautioned that seeing effects in the lab "doesn't always necessarily translate to what you might see in a patient." Some compounds do not cross the blood-brain barrier, which would be essential in the case of Alzheimer's, and some have low bioavailability, meaning they are not readily absorbed into the body or bloodstream.
(Excerpt) Read more at medicalxpress.com ...
Curcumin has its own benefits, but I do not know if it can cross the blood-brain barrier.
Regardless, citicoline and curcumin only prevented the plaques, while green tea extract and resveratrol actually reduced existing plaque material in the lab tests, but those were not representative of having to deal with a blood-brain barrier.
These compounds can’t hurt in reasonable quantities, but aren’t assured of working in the body in the same way, but, it’s possible citicoline could.
My wife and I have used all of them, except Metformin, and had no issues with them.
I assume brandy also has resveratrol.
I’ve never heard of citicoline.
What is citicoline’s relationship to phosphatidylcholine and phosphatidylsterine.
Is citicoline a free standing chemical or is it a part of a supplement.
Are there any downsides to citicoline. Or are there only the upside —that it improves some part of cognitive function
like the phosphatidylcholine and phosphatidylsterine
Have you stopped using curcumin, citicoline, green tea and resveratrol?
Don’t know about brandy. Keep drinking it and buy resveratrol pills. AMZ of course has them, Natural Grocer, other health food stores, some drug stores too.
I drank red wine for decades, full of resveratrol. But decided to quit. Went to Natural Grocer and they had a large selection of brands and dosages of resveratrol. Buy the best you can afford. You cannot take too much.
Citicoline explained at webMD, the site my doctor consults when I want him to prescribe a new vitamin or supplement:
https://www.webmd.com/vitamins/ai/ingredientmono-1090/citicoline
For years now I have drank about 4 cups of green Chai tea every morning and about three times a week I’d have a glass of red wine with my low carb dinner. I’ve already out lived my usefulness so maybe I should switch to coffee and Scotch.
Per the article:
“In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.”
This is all well and good but..?
https://nyulangone.org/news/evidence-mounts-alternate-origins-alzheimers-disease-plaques
Drinking 4 cups of anything each morning means a lot of drinking, but perhaps the benefits are worth it.
The flavor of green tea is rather blah, but Ive always heard it’s good for the body.
bookmarked
Re 10: I drink it mixed with peppermint tea. I hope they do not cancel out.
I recommend Soltea..it’s the equivalent of 35 cups fo green tea without the caffeine. I’ve been taking it for 3 months and notice a difference. More clarity, less brain fog and BP is down and cholestoerol.
The article actually states, in a part I did not post, that the compounds were not tested for crossing the blood-brain barrier and that, along with low bioavailability issues, complicated how these compounds could work in humans.
When I drink my green tea I add a tea bag of pekoe to add a bite of flavor
bkmk
Fever blisters and Shingles are caused by herpes virus. Does that mean that if you get fever blisters of Shingles that you have a greater chance of getting Alzheimer’s?
I take Green Tea extracts and Resveratrol daily, as well as Curcumin.
People tell this 70+ year old that my memory is astonishingly sharp, and I suspect that supplements play a significant role. (So does CPAP, btw)
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