Posted on 08/12/2022 9:00:25 AM PDT by ConservativeMind
Trimethylamine N-oxide (TMAO) widely exists in seafood and is associated with the atherosclerosis progress, but dietary seafood reduced the cardiovascular risk. This intimates that there may be some ingredients in seafood to offset the cardiovascular risk caused by TMAO. Taurine is a marker ingredient in seafood. Thus, this study determined the influences of taurine on TMAO-induced atherosclerosis in apolipoprotein-E-deficient mice. The results showed that dietary taurine significantly reduced the TMAO-induced atherosclerotic lesion area. Further studies found that taurine increased the hepatic- and serum-conjugated bile acid/unconjugated bile acid ratio via increasing hepatic gene expression of conjugated bile acid synthesis. Meanwhile, taurine changed TMAO-induced abnormal bile acid profiles in the gallbladder. Moreover, taurine increased bile acid deconjugation by enhancing the genera Ruminiclostridium level and increased excretion of fecal neutral sterols. Additionally, taurine attenuated inflammation in the serum and artery. These results indicate that taurine alleviated TMAO-induced atherosclerosis via regulating bile acid metabolism.
(Excerpt) Read more at pubmed.ncbi.nlm.nih.gov ...
Taurine actively reduced atherosclerotic legion areas, reduced inflammation, and partly does this through correcting bile acid makeup in the gallbladder.
Taurine is an amino acid we can make when we are younger, but aging reduces these creation processes. It is in meats and in supplement form, as well. It is key to making SOD, a major antioxidant in our cells.
As always, talk with your medical providers when making changes to your diet.
https://www.livestrong.com/article/157099-what-foods-contain-taurine/
And some insight on the negative TMAO studies, from a vegetarian site, to provide a bit of equal time:
What Is TMAO? And Why Should You Avoid It?
About 3g a day was the dosage in this study I believe.
For some reason, I now have a hankering for sushi.
Huh???
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