Posted on 08/12/2022 8:28:37 AM PDT by ConservativeMind
Researchers found a type of common gut bacteria sometimes associated with inflammation, abscesses, bowel disease and cancer has a major silver lining: It seems to help prevent cardiovascular disease.
The findings suggest the possibility of probiotic treatments for atherosclerosis, the dangerous buildup of fats, cholesterol and other substances in arteries that cause strokes and heart attacks and is linked to smoking, diet, age and a range of genetic causes.
Diets heavy in animal-based foods have long been considered a risk factor for cardiovascular disease as such diets are a major source of TMA—trimethylamine—which is converted by the liver to another compound, TMAO, that promotes the buildup of fatty plaque in arteries. TMAO is short for trimethylamine-N-oxide.
"The connection between TMAO and cardiovascular disease has tended to focus the conversation on how animal-based diets cause negative health consequences," said Veronika Kivenson, lead author. "But in analyzing data from foundational gut microbiome studies, we uncovered evidence that one type of bacteria associated with meat consumption can take the TMA, as well as precursors to TMA, and metabolize them without producing any TMAO. That means those bacteria are in effect severing a key link in the cardiovascular disease chain."
Kivenson said, research shows animal-based diets cause a rapid increase in Bilophila in the gut.
Identified only 31 years ago, in an infected appendix, Bilophila is a gram-negative anaerobic rod that's classified as a pathobiont—an organism that normally has a symbiotic relationship with its host but can become disease-causing under certain circumstances. It's commonly present in the microbiomes of people who are healthy.
"The data we reviewed show significantly more Bilophila in the microbiomes of healthy people compared to those with cardiovascular disease, and that Bilophila numbers go up in response to a diet based on meat compared to a plant-based diet," Kivenson said.
(Excerpt) Read more at medicalxpress.com ...
In part, the TMAO effect seems tied to how long TMAO circulates in the bloodstream, and shorter bursts apparently don’t make issues show up, of consequence, according to some analysis I’ve read. However, keeping TMAO from even showing up from foods that should produce it for most people seems to partly come from sometimes pathogenic gut bacteria.
A recent study I may post describes how taurine, an amino acid common in animal-based protein, undoes the damage TMAO starts causing, once in the bloodstream.
on a different topic..for Vitamin D people I ran across this info on one of my gene sites
Reference papers and your DNA
Associations between FTO rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults.
Mehrdad M et al. 2021
This study aimed to investigate the association of the FTO rs9939609 gene polymorphism with eating behaviors, eating disorders, and general mental health in overweight adults (N=197), considering their vitamin D intake as a mediate factor. The polymorphism was selected because it is the most common and strong variant in association studies on obesity, and it is suggested that they might play their role by changing eating behaviors and satiety responsiveness. Eating behaviors were assessed by the Persian version of the Three-Factor Eating Questionnaire-Reduced-18 (TFEQ-R18). The self-report questionnaire has 18 items assessing three dimensions of eating behaviors consisting of cognitive restraint (CR), uncontrolled eating (UE), and emotional eating (EE). In total, 53.8% of the participants had insufficient vitamin D intake. Results of the association analysis between rs9939609 and eating behaviors revealed that participants with AA genotype showed a higher EE score than those with the TT genotype after considering important confounding variables. Moreover, AA genotypes showed a higher EE score than other genotypes in those with insufficient vitamin D intake, while this test did not show any significant differences between the genotypes in terms of UE and eating disorders in those with insufficient vitamin D intake.
www.pubmed.ncbi.nlm.nih.gov/33939949/
Please do not post completely off topic information in these threads.
Post hoc ergo propter hoc.
Another taxpayer grant ‘study’.
I’m shocked that they ‘came up with something’.
It never ends.
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