Posted on 07/29/2022 9:26:08 AM PDT by ConservativeMind
Aging occurs in all sensory organs, and cellular senescence plays an important role in this process. Premature senescence of auditory cells can be induced by oxidative stress and can result in hearing loss. Mitochondrial dysfunction is one of the hallmarks of aging and is associated with the development of age-related neurodegenerative diseases.
Mitochondria generate ATP in cells and are important for energy supply. They are also critical for neurotransmission in the auditory system.
Autophagy is a homeostatic process by which damaged or dysfunctional cellular components are removed. Mitochondrial selective autophagy, termed mitophagy, specifically degrades dysfunctional or damaged mitochondria and maintains a healthy mitochondrial population. Urolithin A (UA) is a natural food metabolite that is abundant in strawberries, pomegranates, and nuts. UA as an activator of mitophagy in both mice and humans prevents the accumulation of damaged or dysfunctional mitochondria and has a favorable safety rating according to standardized toxicology tests.
Aging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells. UA significantly decreased the expression of senescence and increased the expression of mitophagy-related proteins, in senescent cells and cochlear explants. UA significantly increased the ATP content, mitochondrial DNA integrity, and mitochondrial membrane potential in senescent cells. These findings indicate that UA counteracted mitophagy decline and prevented premature senescence in auditory cells. Hence, UA administration might be a promising strategy for preventing mitochondrial dysfunction in patients with age-related hearing loss.
These results indicated that UA induced mitophagy and attenuated premature senescence in auditory cells.
(Excerpt) Read more at nature.com ...
“Urolithin A (UA) is a natural food metabolite that is abundant in strawberries, pomegranates, and nuts.”
Urolithin A is made by bacteria in our guts from the substances primarily available in berries. These substances are ellagic acids and ellagitannins, not Urolithin A. Unfortunately, a prior study showed only 40% of humans have any bacteria that can do this.
I cut and pasted from three parts of the study to help make the excerpt understandable, but, in sum, Urolithin A appears to be able to recover some already damaged hearing-related cells, along with preventing the same damage. It is not a cure-all, but could be helpful.
It also helps a number of other cells work better.
Nestle’s Celltrient division sells this supplement as “Celltrient Cellular Strength,” although the original manufacturer also has it available. Doses tested and considered safe vary between 500 mg to 1,000 mg a day, with 500 mg showing similar results to 1,000 mg in some human studies.
Ping to you.
Many thanks for the info; I’m severely hearing disabled so this is of great importance.
Thanks ! I had heard that direct supplementation with Urolithin A was able to overcome the microbiome/dietary limitations but wasn’t clear on the details. Wish there were more venous or at-home finger-prick blood tests to measure senescence.
Agree. Especially since Urolithin-a is super expensive.
Wondering if Pomegranate extract from Bulk supplements plus gut support (pre/probiotic) would be close
Following this development.
Over the last year I have lost most of the hearing in one ear and fear the other one is going the same way.
Had an MRI to see if there was an acoustic neuroma, but thankfully it is just age related.
I’ve got a bad case of tinnitus.
Celltrient Cellular Strength is expensive but I just bought it.
I’ll try anything that promises to heal the cilia in my inner ear—which is likely where the problem lies. I think that because I sang too close to the band at church for too long. The noise was so loud — I could not hear myself sing—even inside my own head. That kind of loud —breaks the cilia.
I didn’t see any comments as to how long it would take for the healing to take place? —if healing is indeed going to happen...
Did you?
Let us know if it improves your tinnitus.
C.M. Thank for posting this and all your other interesting posts! I know someone who might be interested in this!
No idea, but it will also be working on a number of other cells, so a general health improvement might become noticeable, over time.
Wow, O/T, but my church service is almost silent -- at least during the week -- On Sunday you might hear Gregorian hymns. Loss of hearing is definitely not a hazard at Latin Mass.
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