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Urolithin A attenuates auditory cell senescence by activating mitophagy (Prevents hearing loss)
Nature / Scientific Reports ^ | May 11, 2022 | Sung Il Cho et al

Posted on 07/29/2022 9:26:08 AM PDT by ConservativeMind

Aging occurs in all sensory organs, and cellular senescence plays an important role in this process. Premature senescence of auditory cells can be induced by oxidative stress and can result in hearing loss. Mitochondrial dysfunction is one of the hallmarks of aging and is associated with the development of age-related neurodegenerative diseases.

Mitochondria generate ATP in cells and are important for energy supply. They are also critical for neurotransmission in the auditory system.

Autophagy is a homeostatic process by which damaged or dysfunctional cellular components are removed. Mitochondrial selective autophagy, termed mitophagy, specifically degrades dysfunctional or damaged mitochondria and maintains a healthy mitochondrial population. Urolithin A (UA) is a natural food metabolite that is abundant in strawberries, pomegranates, and nuts. UA as an activator of mitophagy in both mice and humans prevents the accumulation of damaged or dysfunctional mitochondria and has a favorable safety rating according to standardized toxicology tests.

Aging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells. UA significantly decreased the expression of senescence and increased the expression of mitophagy-related proteins, in senescent cells and cochlear explants. UA significantly increased the ATP content, mitochondrial DNA integrity, and mitochondrial membrane potential in senescent cells. These findings indicate that UA counteracted mitophagy decline and prevented premature senescence in auditory cells. Hence, UA administration might be a promising strategy for preventing mitochondrial dysfunction in patients with age-related hearing loss.

These results indicated that UA induced mitophagy and attenuated premature senescence in auditory cells.

(Excerpt) Read more at nature.com ...


TOPICS: Health/Medicine
KEYWORDS: urolithin; urolithina
This line in the study is wrong:

“Urolithin A (UA) is a natural food metabolite that is abundant in strawberries, pomegranates, and nuts.”

Urolithin A is made by bacteria in our guts from the substances primarily available in berries. These substances are ellagic acids and ellagitannins, not Urolithin A. Unfortunately, a prior study showed only 40% of humans have any bacteria that can do this.

I cut and pasted from three parts of the study to help make the excerpt understandable, but, in sum, Urolithin A appears to be able to recover some already damaged hearing-related cells, along with preventing the same damage. It is not a cure-all, but could be helpful.

It also helps a number of other cells work better.

Nestle’s Celltrient division sells this supplement as “Celltrient Cellular Strength,” although the original manufacturer also has it available. Doses tested and considered safe vary between 500 mg to 1,000 mg a day, with 500 mg showing similar results to 1,000 mg in some human studies.

1 posted on 07/29/2022 9:26:08 AM PDT by ConservativeMind
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To: ConservativeMind

Urolithin A

https://en.m.wikipedia.org/wiki/Urolithin_A


2 posted on 07/29/2022 9:26:36 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20% fewer pings) or “Everything” list.

3 posted on 07/29/2022 9:27:17 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: truckdriverswife

Ping to you.


4 posted on 07/29/2022 9:28:49 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Many thanks for the info; I’m severely hearing disabled so this is of great importance.


5 posted on 07/29/2022 9:36:36 AM PDT by WildHighlander57 ((the more you tighten your grip, the more star systems will slip through your fingers.) )
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To: ConservativeMind

Thanks ! I had heard that direct supplementation with Urolithin A was able to overcome the microbiome/dietary limitations but wasn’t clear on the details. Wish there were more venous or at-home finger-prick blood tests to measure senescence.


6 posted on 07/29/2022 10:08:28 AM PDT by erlayman (i)
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To: erlayman

Agree. Especially since Urolithin-a is super expensive.

Wondering if Pomegranate extract from Bulk supplements plus gut support (pre/probiotic) would be close


7 posted on 07/29/2022 10:55:42 AM PDT by Mygirlsmom (Back after a long hiatus. Now mygrandkidsgrandma)
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To: ConservativeMind

Following this development.
Over the last year I have lost most of the hearing in one ear and fear the other one is going the same way.
Had an MRI to see if there was an acoustic neuroma, but thankfully it is just age related.


8 posted on 07/29/2022 11:23:59 AM PDT by chronicles
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To: ConservativeMind

I’ve got a bad case of tinnitus.

Celltrient Cellular Strength is expensive but I just bought it.

I’ll try anything that promises to heal the cilia in my inner ear—which is likely where the problem lies. I think that because I sang too close to the band at church for too long. The noise was so loud — I could not hear myself sing—even inside my own head. That kind of loud —breaks the cilia.

I didn’t see any comments as to how long it would take for the healing to take place? —if healing is indeed going to happen...

Did you?


9 posted on 07/29/2022 5:25:01 PM PDT by ckilmer (qui)
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To: ckilmer

Let us know if it improves your tinnitus.


10 posted on 07/29/2022 5:28:40 PM PDT by gitmo (If your theology doesn't become your biography, what good is it?)
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To: ConservativeMind

C.M. Thank for posting this and all your other interesting posts! I know someone who might be interested in this!


11 posted on 07/29/2022 5:49:41 PM PDT by Pete from Shawnee Mission
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To: ckilmer

No idea, but it will also be working on a number of other cells, so a general health improvement might become noticeable, over time.


12 posted on 07/29/2022 7:51:12 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ckilmer
I think that because I sang too close to the band at church for too long. The noise was so loud — I could not hear myself sing—even inside my own head.

Wow, O/T, but my church service is almost silent -- at least during the week -- On Sunday you might hear Gregorian hymns. Loss of hearing is definitely not a hazard at Latin Mass.

13 posted on 07/29/2022 8:03:21 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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